Hippocampal mnemonic influences on visual cortical neurons.

海马记忆对视觉皮层神经元的影响。

• 批准号: 8460887
• 负责人: Daoyun Ji
• 金额: $ 45.86万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460887
• 关键词: Address; Alzheimer' s Disease; Animals; Area; Back; Binding; Brain; Cells; Data; Disease; Dorsal; Environment; Episodic memory; Event; Excitotoxic lesion; Fire - disasters; Goals; Hippocampus (Brain); Infusion Technique; Infusion procedures; Intervention; Knowledge; Learning; Lidocaine; Location; Mediating; Memory; Mental disorders; Modeling; Monitor; Neocortex; Neurons; Outcome; Pathway interactions; Patients; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Prevention strategy; Process; Property; Rattus; Retrieval; Rodent; Role; Sensory; Sensory Process; Staging; Synapses; Testing; V1 neuron; Visual; Visual Cortex; Visuospatial; Work; area striata; base; experience; insight; memory retrieval; neocortical; nervous system disorder; neuromechanism; neurophysiology; novel; response; theories; visual process; visual processing; visual stimulus; way finding

DESCRIPTION (provided by applicant): Understanding the neural mechanisms of episodic memory is fundamental to memory-related psychiatric and neurological disorders, such as post traumatic stress disorder and Alzheimer's disease. Although it is clear that the neocortex and hippocampus are important for episodic memories, how sensory contents of these memories are stored is unknown. According to current theories, sensory components are stored in the neocortex, whereas the role of hippocampus is to bind the components together. However, there is no evidence for the existence of such neocortical neurons that are involved in processing the sensory components but functionally bound by HP. Our preliminary studies revealed that many cells in the primary visual cortex of freely moving rats fired at specific places of an environment, a property thought to be unique to cells in the hippocampus and its surrounding cortical areas. We hypothesize that these visual cortical neurons are involved in processing the visual components of spatial memories and influenced by hippocampal cells. Using simultaneous tetrode recordings of visual cortical and hippocampal neurons in rats performing spatial navigation tasks, this proposal will investigate the place-specific visual cortical neurons and study whether they are related to spatial learning or memory and whether they depend on the hippocampus.

描述（由申请人提供）：了解情景记忆的神经机制对于记忆相关的精神和神经障碍（如创伤后应激障碍和阿尔茨海默病）至关重要。虽然新皮层和海马体对情景记忆很重要，但这些记忆的感官内容是如何储存的还不清楚。根据目前的理论，感觉成分储存在新皮层中，而海马体的作用是将这些成分结合在一起。然而，没有证据表明存在这样的新皮层神经元，参与处理感觉成分，但功能上受HP约束。我们的初步研究显示，自由活动的大鼠的初级视觉皮层中的许多细胞会向环境中的特定位置发射信号，这一特性被认为是海马体及其周围皮层区域的细胞所独有的。我们假设这些视觉皮层神经元参与处理空间记忆的视觉成分，并受到海马细胞的影响。本研究拟通过对大鼠进行空间导航任务时的视皮层和海马神经元进行同步四极记录，探讨视皮层神经元的位置特异性，并研究它们是否与空间学习记忆有关，以及是否依赖于海马。