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Neurophysiological basis of experience influence in observational fear

经验影响观察恐惧的神经生理学基础

基本信息

批准号：
10091989
负责人：
Daoyun Ji
金额：
$ 41.28万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-05 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10091989
关键词：
Affect Affective Amygdaloid structure Animals Anterior Antisocial Personality Disorder Area Aversive Stimulus Behavior Behavioral Brain Caring Cells Complex Dorsal Electric Stimulation Emotional Empathy Environment Event Fire - disasters Fright Goals Hippocampus (Brain)Human Impairment Investigation Learning Lesion Location Measures Mediating Mental disorders Neurons Outcome Outcome Study Pain Pathway interactions Pattern Process Rattus Rest Rewards Rodent Role Schizophrenia Sensory Social Behavior Social Environment Stimulus Symptoms Testing Time affective neuroscience anti social awake behavior measurement behavior observation behavioral impairment cingulate cortex episodic like memory experience fear memory human imaging imaging approach imaging study improved in vivo memory recall memory retrieval neural circuit neuromechanism neurophysiology novel therapeutic intervention relating to nervous system response sensory input social social attachment social neuroscience

项目摘要

Abstract Humans and animals can sense and respond to aversive experiences of others, an ability crucial for empathy, social bonding and important for survival. Here we study how neural circuits in the brain produce observational fear, a behavior of one subject displaying fearful responses to the observation of another subject in fear. Previous behavioral and human imaging studies have revealed a powerful influence of prior aversive experience on this behavior and have also identified several brain areas involved. However, what neuronal activity patterns in vivo allow one subject to subjectively perceive the others’ experiences as aversive remains mysterious. Given the strong influence of prior experience on observational fear, we propose a hypothesis that the subjective sense of fear upon observation is represented by neurons in the anterior cingulate cortex (ACC), but strongly influenced by a particular neuronal activity pattern in the hippocampus (HP), called awake replay, that recalls prior fearful experiences. We will test the hypothesis by simultaneous recording of a large number of single neurons in ACC and HP in rats during observational fear tasks. We will first determine how HP awake replay and the associated ACC activity patterns are correlated with behavioral measures of observational fear and how they are generated within the HP and ACC neural circuits. Second, we will determine how key factors related to prior experience modulate the ACC/HP activity patterns underlying observational fear. In particular, we will study the effects of recency, valence, spatial and social contexts of prior experience. Finally, we will determine how the ACC/HP activity patterns are causally related to observational fear by disrupting these patterns and then examining its impacts on behavioral measures. The outcomes of this study will significantly advance our understanding of neural circuit computations in observational fear and may reveal a specific in vivo neural mechanism of how it can be produced by recalling prior fearful experiences. This study may open the door to understand antisocial symptoms in mental disorders such as antisocial personality disorder and schizophrenia and may inspire novel therapeutic strategies. 1

摘要人类和动物可以感知并回应他人的厌恶体验，这是一种对同理心至关重要的能力，社会关系和生存的重要因素。在这里，我们研究大脑中的神经回路如何产生观察恐惧，一个受试者对另一个受试者在恐惧中的观察表现出恐惧反应的行为。先前的行为和人类成像研究已经揭示了先前厌恶的强大影响他们对这种行为有着丰富的经验，并确定了涉及的几个大脑区域。然而，什么神经元体内的活动模式允许一个主体主观地将其他主体的经历感知为厌恶的残留物神秘鉴于先前的经验对观察恐惧的强烈影响，我们提出了一个假设，在观察时的主观恐惧感由前扣带皮层（ACC）中的神经元表示，但受到海马体（HP）中一种特殊的神经元活动模式的强烈影响，这种模式被称为清醒重放，会让人想起之前的恐惧经历我们将通过同时记录大量的在观察性恐惧任务中，大鼠ACC和HP的单个神经元。我们先来确定惠普是如何觉醒的重放和相关的前扣带回活动模式与观察性恐惧的行为测量相关以及它们如何在HP和ACC神经回路中产生。其次，我们将确定如何关键因素与先前经验相关的调节ACC/HP活动模式，这些活动模式是观察恐惧的基础。特别是，我们将研究先前经验的近因、效价、空间和社会背景的影响。最后我们将确定ACC/HP活动模式是如何与观察恐惧有因果关系的，模式，然后研究其对行为措施的影响。这项研究的结果将大大推进我们对观察恐惧中神经回路计算的理解，并可能揭示一个特定的它是如何通过回忆先前的恐惧经历而产生的体内神经机制。这项研究可能会打开了解反社会人格障碍等精神障碍中的反社会症状的大门，精神分裂症，并可能激发新的治疗策略。 1

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pattern dynamics and stochasticity of the brain rhythms.

DOI：
10.1073/pnas.2218245120
发表时间：
2023-04-04
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Hoffman, Clarissa;Cheng, Jingheng;Ji, Daoyun;Dabaghian, Yuri
通讯作者：
Dabaghian, Yuri

LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions.