Neurophysiological impacts of hallucinogens on hippocampal and cortical neural circuits

致幻剂对海马和皮质神经回路的神经生理学影响

基本信息

  • 批准号:
    10591612
  • 负责人:
  • 金额:
    $ 36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Recent years have seen a dramatic increase in the interest of using psychedelics as experimental therapies for drug addition, depression and anxiety disorders. However, psychedelics are also powerful drugs that alter neural functions in the brain. To understand their potential benefits or risks, it is important to determine the neurophysiological effects of psychedelics on neural circuits in vivo. The psychedelic drug lysergic acid diethylamide (LSD) is a classic hallucinogen that can alter perceptual and cognitive functions in humans and animals. This project studies the neurophysiological impacts of LSD on the sensory and memory neural circuits in freely behaving rats. We will focus on a hypothesis that the interactions between the visual cortex and the hippocampus are reduced by LSD, which leads to imprecise spatial representations during active spatial navigation and impaired neural activity reactivations during offline behavior that are important for memory retrieval and consolidation. To test the hypothesis, we will simultaneously record neurons in the hippocampus and the visual cortex while rats under LSD learn or perform a spatial working memory task and while they sleep. We will determine how hippocampal and visual cortical activities and their interactions are altered by LSD during active and immobile behavior and during sleep, how the alterations depend on LSD dosage and the serotonergic 5HT2A receptors, how they are correlated with behavioral task performances, and how they can be augmented or alleviated by manipulating the network oscillations typical of active and offline behavior. This study will reveal the in vivo neurophysiological effects of the psychedelic drug LSD, advance our understanding on how alterations in the sensory and memory circuits may contribute to the psychotic state generated by drugs and in psychiatric disorders such as schizophrenia, and uncover potential risks when psychedelics are explored as novel therapies for drug addiction and mental disorders.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Daoyun Ji其他文献

Daoyun Ji的其他文献

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{{ truncateString('Daoyun Ji', 18)}}的其他基金

Neurophysiological impacts of hallucinogens on hippocampal and cortical neural circuits
致幻剂对海马和皮质神经回路的神经生理学影响
  • 批准号:
    10444822
  • 财政年份:
    2022
  • 资助金额:
    $ 36万
  • 项目类别:
Neurophysiological basis of experience influence in observational fear
经验影响观察恐惧的神经生理学基础
  • 批准号:
    10091989
  • 财政年份:
    2017
  • 资助金额:
    $ 36万
  • 项目类别:
Abnormal spatial memory processing in tau pathology and neurodegeneration
tau 病理学和神经变性中的异常空间记忆处理
  • 批准号:
    10238047
  • 财政年份:
    2017
  • 资助金额:
    $ 36万
  • 项目类别:
Abnormal spatial memory processing in tau pathology and neurodegeneration
tau 病理学和神经变性中的异常空间记忆处理
  • 批准号:
    9750831
  • 财政年份:
    2017
  • 资助金额:
    $ 36万
  • 项目类别:
In vivo neurophysiological study of a neurodegenerative mouse model
神经退行性小鼠模型的体内神经生理学研究
  • 批准号:
    8303708
  • 财政年份:
    2012
  • 资助金额:
    $ 36万
  • 项目类别:
In vivo neurophysiological study of a neurodegenerative mouse model
神经退行性小鼠模型的体内神经生理学研究
  • 批准号:
    8412768
  • 财政年份:
    2012
  • 资助金额:
    $ 36万
  • 项目类别:
Hippocampal mnemonic influences on visual cortical neurons.
海马记忆对视觉皮层神经元的影响。
  • 批准号:
    8656345
  • 财政年份:
    2011
  • 资助金额:
    $ 36万
  • 项目类别:
Hippocampal mnemonic influences on visual cortical neurons.
海马记忆对视觉皮层神经元的影响。
  • 批准号:
    8261875
  • 财政年份:
    2011
  • 资助金额:
    $ 36万
  • 项目类别:
Hippocampal mnemonic influences on visual cortical neurons.
海马记忆对视觉皮层神经元的影响。
  • 批准号:
    8460887
  • 财政年份:
    2011
  • 资助金额:
    $ 36万
  • 项目类别:
Hippocampal mnemonic influences on visual cortical neurons.
海马记忆对视觉皮层神经元的影响。
  • 批准号:
    8547164
  • 财政年份:
    2011
  • 资助金额:
    $ 36万
  • 项目类别:

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