Comparative Effects of Two Popular Diets in Veterans with the Metabolic Syndrome

两种流行饮食对患有代谢综合征的退伍军人的比较效果

• 批准号: 8392116
• 负责人: MICHAEL MILLER
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8392116
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Antioxidants; Area; Atherosclerosis; Biochemical; Blood Pressure; Blood Vessels; Body Composition; Body Weight; Body Weight decreased; CETP gene; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Clinical Trials; Complex; Data; Diet; Diet Modification; Dietary Fats; Dual-Energy X-Ray Absorptiometry; Dyslipidemias; Endothelium; Enzymes; Evaluation; Event; Exercise; Family member; Fatty Acids; General Population; Glucose; Health; Health Benefit; Healthcare; High Density Lipoproteins; Homeostasis; Impairment; Incidence; Insulin; Insulin Resistance; Investigation; Laboratories; Lead; Life Style; Lifestyle Therapy; Lipid Peroxidation; Lipids; Lipoproteins; Long-Term Effects; Mediating; Mediterranean Diet; Metabolic; Metabolic syndrome; Mission; Modeling; Monounsaturated Fatty Acids; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Physical activity; Physiological; Polyunsaturated Fatty Acids; Population; Prevalence; Property; Proteins; Recommendation; Regimen; Research; Rest; Risk; Risk Factors; Structure; Testing; Therapeutic; United States Dept. of Health and Human Services; Unsaturated Fats; Vasodilation; Veterans; Visceral; Walking; Weight; Weight maintenance regimen; Woman; X-Ray Computed Tomography; adiponectin; brachial artery; cardiovascular disorder risk; comparative; design; diabetic; diet and exercise; disorder prevention; fasting glucose; fitness; good diet; improved; inflammatory marker; interest; lipid transfer protein; men; monounsaturated fat; news; polyunsaturated fat; programs; public health relevance; response; saturated fat; waist circumference

DESCRIPTION (provided by applicant): The Metabolic Syndrome (MetS) is a common problem among Veterans and is associated with a greater likelihood of cardiovascular disease (CVD). The Mediterranean diet is the only popular diet that has been shown to reduce CVD event rates but the extent to which monounsaturated fatty acid (MUFA) or polyunsaturated fatty acid (PUFA) enrichment results in improvement in parameters of MetS is unresolved. Similarly, while low intensity exercise improves the CVD risk factor profile, there have been no comparative investigations comparing MUFA and PUFA enriched diets and exercise in patients with MetS that have extended beyond 1 year. Recently, the VA established the MOVE! program, a national weight management program designed to help Veterans lose weight. Using the VA promoted program, we will perform a systematic evaluation of the effects of dietary fat composition [comparison between MUFA-enriched and PUFA enriched diet] with MOVE!. We hypothesize that a MUFA-enriched diet consisting of antioxidant, lipid reducing and insulin sensitizing properties will be superior to the less palatable PUFA- enriched diet on improving cardiometabolic parameters associated with MetS. Specifically, the MUFA MOVE! program is expected to lead to greater improvements than the PUFA MOVE! program in body composition and aerobic fitness (Specific Aim 1), endothelial dependent flow mediated vasodilation and the postprandial lipid response to a meal load (Specific Aim 2) and the mechanisms (lipolytic and lipid transfer protein activity, homeostasis model assessment-estimated insulin resistance) responsible for these effects (Specific Aim 3). Collectively, these studies will advance our understanding of mechanisms underlying the differential effects of MUFA and PUFA-enriched dietary regimens on cardiometabolic health and when combined with the MOVE! program, will provide new and useful information to Veterans (and the general public) interested in optimizing their diets for CVD disease prevention and improved vascular health.

描述(由申请人提供)： 代谢综合征(METS)是退伍军人中的常见问题，与心血管疾病(CVD)的可能性更大相关。地中海饮食是唯一被证明可以降低心血管事件发生率的流行饮食，但单不饱和脂肪酸(MUFA)或多不饱和脂肪酸(PUFA)的丰富在多大程度上改善了蛋氨酸的参数尚不清楚。同样，虽然低强度运动改善了心血管疾病风险因素的概况，但还没有比较MUFA和PUFA丰富的饮食和运动对持续1年以上的MET患者的比较研究。最近，退伍军人事务部成立了这一举措！这是一项旨在帮助退伍军人减肥的全国性体重管理计划。使用VA Promoted计划，我们将使用MOVE！对膳食脂肪组成[富MUFA和PUFA强化饮食之间的比较]的影响进行系统评估。我们推测，在改善与蛋氨酸相关的心脏代谢参数方面，富含多不饱和脂肪酸的饮食包括抗氧化剂、降脂和胰岛素增敏特性，将优于不那么可口的多不饱和脂肪酸丰富的饮食。具体地说，就是曼联的举动！该计划有望带来比PUFA举措更大的改善！这些项目包括身体成分和有氧健身(特定目标1)、内皮依赖血流介导的血管扩张和餐后脂肪对饮食负荷的反应(特定目标2)以及导致这些影响的机制(特定目标3)(脂解和脂质转移蛋白活性、稳态模型评估-估计的胰岛素抵抗)。总而言之，这些研究将促进我们对MUFA和PUFA强化饮食方案对心脏代谢健康的不同影响的潜在机制的理解，以及当与MOVE结合时！该计划将为退伍军人(和普通公众)提供新的有用信息，这些信息有兴趣优化他们的饮食以预防心血管疾病和改善血管健康。