SLAM Gene Family Controlled Pathways to SLE

SLAM 基因家族控制 SLE 通路

基本信息

项目摘要

DESCRIPTION (provided by applicant): This application seeks support for elucidating the role of the SLAMF receptors in the pathogenesis of Systemic Lupus Erythematosus (SLE) with the ultimate goal to develop SLAMF-based therapeutic strategies that can be applied to SLE patients. Because of the outcomes of our studies with cells derived from SLE patients and our exciting findings with genetically altered mice, which develop lupus-related autoimmunity, we now have the systems in place to dissect how cell interaction mechanisms and signaling initiated by the SLAMF receptors contribute to the control of tolerance to autoantigens and to the pathogenesis of human SLE. These insights and tools are the basis for a Program Project application entitled: "SLAM FAMILY RECEPTOR CONTROLLED PATHWAYS TO SLE" for three interlinked projects and two supporting Cores. Project #1 The SlamfS, Slamf5 and Slamf6 receptor-induced pathways to murine lupus. PL: Cox Terhorst, Beth Israel Deaconess Medical Center. Project #2 Functional analyses of human and mouse SLAMF4"SLAMF2 receptor / ligand interactions in murine and human SLE. PL: Arlene Sharpe, Department of Microbiology and Immunobiology, Harvard Medical School. Project #3 Function of human SLAMF receptors in SLE immune cells. PL: George Tsokos, Beth Israel Deaconess Medical Center. Core A Genetic Mouse Core.PL: Ninghai Wang, Beth Israel Deaconess Medical. Center Core B Administrative Core.PL Cox Terhorst, Beth Israel Deaconess Medical Center.
描述(由申请人提供):

项目成果

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CORNELIS P TERHORST其他文献

CORNELIS P TERHORST的其他文献

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{{ truncateString('CORNELIS P TERHORST', 18)}}的其他基金

Primary Immuno-Deficiencies Affecting Specific Stages of the Immune Response
影响免疫反应特定阶段的原发性免疫缺陷
  • 批准号:
    8296689
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Primary Immuno-Deficiencies Affecting Specific Stages of the Immune Response
影响免疫反应特定阶段的原发性免疫缺陷
  • 批准号:
    7560933
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Role of SAP (SH2D1A) gene in T cell-dependent antibody response
SAP (SH2D1A) 基因在 T 细胞依赖性抗体反应中的作用
  • 批准号:
    7614096
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Primary Immuno-Deficiencies Affecting Specific Stages of the Immune Response
影响免疫反应特定阶段的原发性免疫缺陷
  • 批准号:
    8102821
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Primary Immuno-Deficiencies Affecting Specific Stages of the Immune Response
影响免疫反应特定阶段的原发性免疫缺陷
  • 批准号:
    7882569
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
IMMUNE
免疫
  • 批准号:
    7885362
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Primary Immuno-Deficiencies Affecting Specific Stages of the Immune Response
影响免疫反应特定阶段的原发性免疫缺陷
  • 批准号:
    8501241
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    7614102
  • 财政年份:
    2009
  • 资助金额:
    $ 151.41万
  • 项目类别:
SLAM Gene Family Controlled Pathways to SLE
SLAM 基因家族控制 SLE 通路
  • 批准号:
    7275918
  • 财政年份:
    2006
  • 资助金额:
    $ 151.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8733827
  • 财政年份:
    2006
  • 资助金额:
    $ 151.41万
  • 项目类别:

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