Clinical, Laboratory, and Data Management Core

项目总结（见说明）：临床、实验室和数据管理核心（核心B）建立了收集、存储和传播临床和实验室数据以及受试者标本的基础设施，以支持项目1、2和3中提出的科学目标。它位于西北大学（NU）的物理位置和协调，并作为招募具有良好特征的CRS三级护理患者的主要站点。核心B将提供数据和样本一致性的监督，并作为拟议的跨机构项目的联系点。为了实现这些目标。核心B将提高NU CRS患者临床表征的分辨率，并提供跟踪纵向结局的机制，以增强项目2和项目3中发现的临床影响。为确保项目1和项目2样品采集的一致性，核心将对相关人员进行培训，并提供样品采集方案共享的平台。核心B还提供了引导和优化用于生成P2和P3的微生物刺激样本的方案的资源。最后，它为所有三个项目提供了符合HlPAA的临床数据收集、标本跟踪和数据传播的信息技术基础设施。核心主任，罗伯特克恩，医学博士，是在NU耳鼻喉科主席，具有丰富的行政和临床经验。其他关键人员包括Atsushi Kato博士（Co-I），他是核心实验室部分的领导者。加藤博士在免疫学研究方面有着丰富的经验，特别是CRS研究。布鲁斯谭，医学博士（Co-I）是一位具有鼻窦疾病临床专业知识和分子和细胞生物学实验室经验的医生科学家。Tan博士目前是K23赠款获得者，对CRS的流行病学和数据管理以及应用于临床研究的信息技术感兴趣并有经验。此外，核心B通过Warren Kibbe博士领导的生物信息学中心（NUBIC）利用NU的机构专业知识; Alfred Rademaker博士领导的生物统计学合作中心（BCC）;以及Frank Schleicher领导的Feinberg医学院（FSM）信息系统董事会。

PROJECT SUMMARY (See instructions): The Clinical, Laboratory and Data Management Core (Core B) establishes infrastructure to collect, store and disseminate clinical and laboratory data as well as specimens from subjects in support ofthe scientific aims proposed in Projects 1, 2 and 3. It is physically located and coordinated at Northwestern University (NU) and serves as a primary site for the recruitment of well-characterized tertiary-care patients with CRS. Core B will provide oversight of data and specimen consistency and serve as the nexus for the trans-institutional projects proposed. To achieve these aims. Core B will increase the resolution of clinical characterization of CRS patients at NU and provide a mechanism for tracking longitudinal outcomes to enhance the clinical impact of findings in Project 2 and Project 3. To ensure consistency of sample acquisition in Project 1 and Project 2, the core will conduct training for relevant personnel and provide a platform for sharing of protocols for sample acquisition. Core B also provides a resource that pilots and optimizes protocols for generating microbial-stimulated specimens for P2 and P3. Finally, it provides the information technology infrastructure for HlPAA-compliant clinical data collection, specimen tracking and data dissemination for all three projects. The Core Director, Robert Kern, MD, is the Chairman of Otolaryngology at NU, with extensive administrative and clinical experience. Other key personnel include Atsushi Kato, PhD (Co-I), who is the leader ofthe laboratory portion ofthe core. Dr. Kato has extensive experience in immunology research, and CRS research in particular. Bruce Tan, MD (Co-I) is a physician scientist with clinical expertise in sinonasal disorders and laboratory experience in molecular and cell biology. Dr. Tan, a current K23 grant recipient, has interest and experience in the epidemiology of CRS and data management and in information technology as applied to clinical research. Additionally, Core B leverages institutional expertise available at NU through the Bioinformatics Center (NUBIC) under Warren Kibbe, PhD; the biostatistics collaboration center (BCC) under Alfred Rademaker, PhD; and the Feinberg School of Medicine (FSM) information systems directorate under Frank Schleicher.