Predictors of ART Adherence for Behaviorally-Infected HIV+ African-American Males

行为感染 HIV 的非裔美国男性 ART 依从性的预测因素

• 批准号: 8550543
• 负责人: Israel Gross
• 金额: $ 2.89万
• 依托单位: LOYOLA UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-07 至 2014-09-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550543
• 关键词: AIDS/HIV problem; Adherence; Adolescent; Adolescent Medicine Trials Network; Affect; African American; Age; Anti-Retroviral Agents; Antiretroviral resistance; Buffers; CD4 Positive T Lymphocytes; Centers for Disease Control and Prevention (U.S.); Classification; Data; Data Analyses; Disease; Disease Progression; Dose; Epidemic; Exhibits; Future; General Population; Goals; HIV; HIV Infections; Household; Individual; Intervention; Life; Life Expectancy; Literature; Male Adolescents; Medical; Mental Health; Minority Groups; Modeling; Morbidity - disease rate; Multivariate Analysis; Mutate; Outcome; Participant; Pathway interactions; Pharmaceutical Preparations; Physician-Patient Relations; Prevention program; Preventive Intervention; Production; Protocols documentation; Provider; Public Health; Quality of life; Regimen; Research; Research Training; Risk; Risk Factors; Self Efficacy; Social support; Substance abuse problem; Techniques; Translating; Trees; United States; Viral; Viral Load result; Virus; antiretroviral therapy; compliance behavior; depressive symptoms; effective therapy; high risk; innovation; intervention program; male; medication compliance; mortality; particle; patient population; psychosocial; response; standard of care; therapy adherence; transmission process; young adult

DESCRIPTION (provided by applicant): The HIV/AIDS epidemic has affected millions of individuals worldwide over the past 30 years. Although there is currently no cure for HIV/AIDS, significant pharmacological advances in the treatment of HIV/AIDS have been developed, which has greatly extended the life expectancy and quality of life for individuals living with the diseas. Specifically, since 1996 antiretroviral (ARV) medication has been the standard of care in the United States, reducing the production of HIV viral particles in the body, as well as restoring the host body's immunological functioning. However, in order for (ARV) medication to be effective, a nearly 100% medication dose adherence rate is required. Individuals infected with HIV/AIDS on ARV medication regimens who are not adherent pose a significant public health risk as they are (a) at greater risk for disease progression; (b) more likely to be resistant to ARV medication treatment in the future; and (c) are more likely to transmit the virus to the general public, as wel as transmit mutated strains of the disease, which have a poorer response to ARV treatment. Adolescents and individuals from racial/ethnic minority backgrounds have been documented to have poor ARV adherence. Although prior studies have identified psychiatric illness and substance abuse to be strong predictors of ARV adherence, there is little research that examines the predictors of adherence among young adult and adolescent African American males, a demographic group at great risk for both HIV infection and ARV non-adherence. Therefore the objectives of the current study are to (a) identify the strongest predictors of ART adherence among African American adolescent and young adult males (<24 years) behaviorally infected with HIV; (b) to create a classification tree analysis model of adherence that maximizes classification accuracy for adherence and non-adherence; and (c) to identify the protective and risk factors that can be incorporated into intervention and prevention programs that increase ARV adherence. For the purpose of this study, a subsample of 790 African American males (<24 years) behaviorally-infected with HIV, who participated in the Adolescent Trials Network for HIV/AIDS Interventions (ATN) 086 protocol in 2010-2011, will be investigated using an exploratory multivariate analysis technique known as Optimal Data Analysis (ODA). ODA will allow the identification of the strongest predictor of adherence among a plethora of demographic, psychosocial, and biomedical data without increasing error. In addition, a classification tree analysis model will be created highlighting the pathways to adherence and non-adherence among African American males behaviorally-infected with HIV.

描述（由申请人提供）：艾滋病毒/艾滋病流行病在过去30年中影响了全世界数百万人。虽然目前无法治愈艾滋病毒/艾滋病，但在治疗艾滋病毒/艾滋病方面取得了重大药理学进展，大大延长了患者的预期寿命和生活质量。具体来说，自1996年以来，抗逆转录病毒（ARV）药物一直是美国的标准治疗方法，减少了体内HIV病毒颗粒的产生，并恢复了艾滋病毒的免疫功能