Inhibition of AMPK signalling as a strategy for decreasing appetite

抑制 AMPK 信号作为降低食欲的策略

• 批准号: nhmrc : 1145836
• 负责人: Dr Kim Loh
• 金额: $ 43.56万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-ampk-signalling-decreasing-appetite/1320544
• 关键词: Inhibition; AMPK; signalling; strategy; decreasing

The enzyme AMP-activated protein kinase (AMPK) has previously been implicated in mediating increased food intake in response to fasting and the appetite-inducing hormone ghrelin. In this study we propose to investigate whether inhibition of AMPK has promise as a strategy to reduce hunger in the context of dietary restriction and increases in energy expenditure, such as exercise. We will also test whether a new AMPK inhibitor has the potential to reduce appetite signalling in cells and in mice.

amp活化蛋白激酶（AMPK）先前被认为与介导食物摄入增加以应对禁食和食欲诱导激素ghrelin有关。在这项研究中，我们建议调查AMPK的抑制是否有希望作为一种策略，在饮食限制和能量消耗增加的背景下减少饥饿，如运动。我们还将测试一种新的AMPK抑制剂是否有可能减少细胞和小鼠的食欲信号。