Uncovering a novel energy-sensing mechanism in the brain

发现大脑中一种新颖的能量传感机制

• 批准号: FT230100423
• 负责人: Dr Kim Loh
• 金额: $ 53.07万
• 依托单位: Australian Catholic University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100423
• 关键词: Uncovering; novel; energy; sensing; mechanism

This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundamental insights into how SIK3 in the hypothalamic neurons regulates energy homeostasis. Benefits include improving population health and wellbeing, informing the development of new bio-medical technologies, and expanding the capabilities of Australia’s next generation of researchers.

该项目旨在研究一种新的大脑能量稳态调节剂，一种名为SIK3的蛋白激酶。能量平衡是生命的关键，因为它确保了身体细胞的燃料供应充足。该项目旨在通过使用创新的基因技术和转基因动物模型来产生关于调节能量稳态的分子开关的新知识。预期的结果包括对下丘脑神经元中的SIK3如何调节能量稳态产生基本的见解。好处包括改善人口健康和福祉，为新的生物医学技术的发展提供信息，并扩大澳大利亚下一代研究人员的能力。