The role of the central insulin-NPY pathway in the regulation of energy balance

中枢胰岛素-NPY通路在能量平衡调节中的作用

• 批准号: nhmrc : 1080473
• 负责人: Dr Kim Loh
• 金额: $ 31.67万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-central-insulin-energy-balance/518748
• 关键词: role; central; insulin; NPY; pathway

Insulin is known for its role in the regulation of glucose metabolism in the liver, muscle and fat, however very little is known about the role of insulin in the brain. This project aims to improve our understanding on how insulin regulates energy balance and appetite and identifies the exact neuronal networks involved in the brain and to understand the mechanistic insights into the pathology of obesity, providing the means for the development of more effective and safer therapeutic approaches.

众所周知，胰岛素在肝脏、肌肉和脂肪中调节葡萄糖代谢的作用，但对胰岛素在大脑中的作用知之甚少。该项目旨在提高我们对胰岛素如何调节能量平衡和食欲的理解，并确定参与大脑的确切神经元网络，并了解肥胖病理学的机理，为开发更有效，更安全的治疗方法提供手段。