Piezoelectric Pump to supply Ventricular Assist Device for Fontan Patients

压电泵为 Fontan 患者提供心室辅助装置

• 批准号: 8453288
• 负责人: Conal O'Neill
• 金额: $ 20.08万
• 依托单位: KINETIC CERAMICS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453288
• 关键词: Adult; Affect; Aircraft; Aneurysm; Artificial Heart; Assisted Circulation; Automobile Driving; Award; Blood Circulation; Blood flow; Cardiac; Cardiology; Cardiovascular system; Cause of Death; Ceramics; Child; Childhood; Collaborations; Common Ventricle; Communities; Congenital Abnormality; Coupled; Custom; Defect; Development; Devices; Electromagnetics; Engineering; Failure; Film; Fontan Procedure; Frequencies; Health; Heart Transplantation; Heart failure; Hospitalization; In Vitro; Infant; International; Kinetics; Laboratories; Left; Lung; Magnetism; Mechanics; Methods; Motor; Operative Surgical Procedures; Output; Parents; Patients; Pediatric Hospitals; Peripheral arterial disease; Physics; Population; Power Sources; Pulmonary Circulation; Pump; Rehabilitation therapy; Research; Risk; Solutions; Stents; Structure; System; Technology; Testing; Time; Venous Pressure level; base; blood pump; cost; density; design; fluid flow; implantable device; improved; miniaturize; nitinol; novel; novel strategies; pressure; prototype; ventricular assist device

DESCRIPTION (provided by applicant): Congenital cardiovascular defects, specifically single ventricle abnormalities, constitute the most common cause of death among infants born with birth defects. Even after surgically rerouting the single ventricle circulation via the Fontan procedure, the circulation in these patients relies on blood flowing passively through the lungs. Thus, this group of patients is continually at risk for Fontan failure and its consequences. Thus, there is a need for a compact method to drive implantable ventricular assist devices used to re-energize blood flow in these patients. Over the last decade, our team has made advances in frequency rectification concepts that have yielded novel compact piezoelectric hydraulic pumps for morphing aircraft structures. While representing a significant advancement in aerospace, they have yet to be considered as drivers for mechanical circulatory support devices. It is our hypothesis that these new high power devices can be effectively used as miniature assist device driver for Fontan circulation. We propose to develop and evaluate a novel piezoelectric hydraulic pump driver tailored to re-energize blood flow to the lungs for patients with the Fontan circulation. It is our hypothesis that the piezohydraulic technology represents a novel approach to construct a miniaturized ventricular assist device driver for both pediatric and adult Fontan patients. The focus of this research is to experimentally demonstrate the ability of a piezoelectri pump to transfer power to the Fontan circulation and assist blood flow in Fontan patients. We plan to utilize the new piezoelectric hydraulic pump to drive a commercial short term circulatory support device and also a long term implantable device fabricated at UCLA. This device will be characterized in vitro to demonstrate that the system can increase fluid flow through the pulmonary circulation while reducing systemic venous pressure in a mock Fontan fluidic circuit. To date, mechanical assist device drivers small enough for pediatric patients are non-existent. The proposed effort will not only provide the opportunity for realization of a unique device to aid patients with the Fontan circulation, but it will also provide an outline for the use of compact hih power density piezoelectric devices for use as mechanical circulatory support drivers

描述（由申请人提供）：先天性心血管缺陷，特别是单心室异常，构成出生缺陷婴儿最常见的死亡原因。即使通过 Fontan 手术重新路由单心室循环后，这些患者的循环仍然依赖于被动流经肺部的血液。因此，这组患者持续面临 Fontan 衰竭及其后果的风险。因此，需要一种紧凑的方法来驱动植入式心室辅助装置，以重新激活这些患者的血流。 在过去的十年中，我们的团队在频率整流概念方面取得了进步，产生了用于变形飞机结构的新型紧凑型压电液压泵。虽然代表了航空航天领域的重大进步，但它们尚未被视为机械循环支持设备的驱动力。我们假设这些新的高功率设备可以有效地用作 Fontan 循环的微型辅助设备驱动器。我们建议开发和评估一种新型压电液压泵驱动器，专门为患有 Fontan 循环的患者重新激活流向肺部的血液。我们的假设是，压电液压技术代表了一种为儿童和成人 Fontan 患者构建小型心室辅助装置驱动器的新方法。这项研究的重点是通过实验证明压电泵将动力传输到 Fontan 循环并协助 Fontan 患者血流的能力。我们计划利用新型压电液压泵来驱动商业短期循环支持装置以及加州大学洛杉矶分校制造的长期植入装置。该装置将在体外进行表征，以证明该系统可以增加通过肺循环的流体流量，同时降低模拟 Fontan 流体回路中的全身静脉压。迄今为止，尚不存在足够小以供儿科患者使用的机械辅助装置驱动器。所提出的努力不仅将提供实现独特设备的机会，以帮助 患有 Fontan 循环的患者，但它也将为使用紧凑型高功率密度压电器件作为机械循环支持驱动器提供概述