Yale Center for Sleep Disturbance in Acute and Chronic Conditions

描述（由申请人提供）：耶鲁大学急性和慢性睡眠障碍中心将专注于知识的创造，这将导致在急性和慢性疾病的轨迹上改善睡眠障碍的评估和生物行为管理，并最终改善患者报告的结果、发病率和死亡率。该中心将建立在耶鲁大学护理学院和医学院与耶鲁大学CTSA之间牢固的研究关系，以及我们在睡眠障碍、急性和慢性疾病管理以及自我和家庭管理干预的开发和测试方法方面的跨学科专业知识的基础上。本项目的目的和中心的目标是：1)扩大研究的数量和质量，以提高对睡眠障碍与急性和慢性疾病之间生物行为关系的理解；睡眠障碍对发病率、死亡率、功能和生活质量的影响；评估和生物行为管理的急性/慢性睡眠障碍人群跨越人类生命周期和在不同的家庭和卫生保健机构；2)发展中心研究人员的专业知识：生态有效的睡眠测量方法，最好地捕捉睡眠属性和睡眠相关的结果，在急性/慢性疾病中是重要的，在各种人群和环境中是可行的；解决睡眠障碍的多维性和时代性的统计方法；开发和测试急性/慢性睡眠障碍的管理和自我管理干预措施；3)在耶鲁大学内部以及与外部合作伙伴（包括其他NINR中心的合作伙伴）建立和维持跨学科合作伙伴关系，以增加对急性/慢性睡眠障碍的研究；4)扩大耶鲁大学强大的研究基础设施，为跨学科睡眠障碍研究提供更多支持。一个方法核心将支持中心的科学方向，四项试点研究将由有前途的青年科学家进行。

DESCRIPTION (provided by applicant): The proposed Yale Center for Sleep Disturbance in Acute and Chronic Conditions will focus on the creation of knowledge that will lead to improvements in the assessment and bio-behavioral management of sleep disturbance across the trajectory of acute and chronic conditions and ultimate improvements in patient-reported outcomes, morbidity, and mortality. The Center will build on the strong research relationships among the Yale Schools of Nursing and Medicine and the Yale CTSA and our interdisciplinary expertise in sleep disturbance, management of acute and chronic conditions, and methods of development and testing of self- and family management interventions. The aims of this project and the goals of the Center are to: 1) Expand the number and quality of research studies designed to improve understanding of the bio-behavioral relationships between sleep disturbance and acute and chronic conditions; the contributions of sleep disturbance to morbidity, mortality, function and quality of life; and assessment and biobehavioral management of sleep disturbance in acute/chronic conditions among populations spanning the human lifespan and in various home and health care settings; 2) Develop expertise among Center investigators in: ecologically valid sleep measurement methods that best capture the sleep attributes and sleep-related outcomes that are important in acute/chronic conditions and feasible in various populations and settings; statistical methods that address the multi-dimensional and temporal nature of sleep disturbance; and development and testing of interventions for management and self-management of sleep disturbance in acute/chronic conditions; 3) Build and sustain interdisciplinary partnerships within Yale and with external partners, including those in other NINR Centers, to increase research on sleep disturbance in acute/chronic conditions; and 4) Expand the strong research infrastructure at Yale to provide enhanced support for interdisciplinary sleep disturbance research. A Methods Core will support the scientific directions of the Center and four pilot studies will be conducted by promising junio scientists.