Yale Center for Sleep Disturbance in Acute and Chronic Conditions

描述(申请人提供)：耶鲁大学急慢性睡眠障碍研究中心将致力于创造知识，从而改善急慢性睡眠障碍的评估和生物行为管理，并最终改善患者报告的结果、发病率和死亡率。该中心将建立在耶鲁护理医学院和耶鲁CTSA之间强大的研究关系以及我们在睡眠障碍、急性和慢性疾病的管理以及自我和家庭管理干预的开发和测试方法方面的跨学科专业知识的基础上。该项目和中心的目标是：1)扩大研究研究的数量和质量，旨在提高对睡眠障碍与急性和慢性病之间的生物行为关系的了解；睡眠障碍对发病率、死亡率、功能和生活质量的贡献；以及在人的一生中以及在各种家庭和医疗保健环境中对急性/慢性病中的睡眠障碍进行评估和生物行为管理；2)在中心研究人员中培养以下方面的专门知识：最好地捕捉在急性/慢性病中重要且在各种人群和环境中可行的睡眠属性和睡眠相关结果的生态有效的测量方法；耶鲁大学的研究重点包括：(1)采用科学的统计方法解决睡眠障碍的多维性和时间性；以及(3)开发和测试急性/慢性睡眠障碍的管理和自我管理干预措施；3)在耶鲁大学内部以及与其他NINR中心的合作伙伴之间建立和保持跨学科的伙伴关系，以增加对急性/慢性病睡眠障碍的研究；以及4)扩大耶鲁强大的研究基础设施，为跨学科的睡眠障碍研究提供更多的支持。一个方法核心将支持该中心的科学指导，有前途的青年科学家将进行四项初步研究。

DESCRIPTION (provided by applicant): The proposed Yale Center for Sleep Disturbance in Acute and Chronic Conditions will focus on the creation of knowledge that will lead to improvements in the assessment and bio-behavioral management of sleep disturbance across the trajectory of acute and chronic conditions and ultimate improvements in patient-reported outcomes, morbidity, and mortality. The Center will build on the strong research relationships among the Yale Schools of Nursing and Medicine and the Yale CTSA and our interdisciplinary expertise in sleep disturbance, management of acute and chronic conditions, and methods of development and testing of self- and family management interventions. The aims of this project and the goals of the Center are to: 1) Expand the number and quality of research studies designed to improve understanding of the bio-behavioral relationships between sleep disturbance and acute and chronic conditions; the contributions of sleep disturbance to morbidity, mortality, function and quality of life; and assessment and biobehavioral management of sleep disturbance in acute/chronic conditions among populations spanning the human lifespan and in various home and health care settings; 2) Develop expertise among Center investigators in: ecologically valid sleep measurement methods that best capture the sleep attributes and sleep-related outcomes that are important in acute/chronic conditions and feasible in various populations and settings; statistical methods that address the multi-dimensional and temporal nature of sleep disturbance; and development and testing of interventions for management and self-management of sleep disturbance in acute/chronic conditions; 3) Build and sustain interdisciplinary partnerships within Yale and with external partners, including those in other NINR Centers, to increase research on sleep disturbance in acute/chronic conditions; and 4) Expand the strong research infrastructure at Yale to provide enhanced support for interdisciplinary sleep disturbance research. A Methods Core will support the scientific directions of the Center and four pilot studies will be conducted by promising junio scientists.