Personalized Bio-behavioral Weight Loss Intervention for African American Women

针对非裔美国女性的个性化生物行为减肥干预

• 批准号: 8513419
• 负责人: Gayenell Smith Magwood
• 金额: $ 9.11万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-18 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8513419
• 关键词: Address; Adult; Affect; African American; Age; Area; Behavior; Behavior Therapy; Behavioral; Behavioral Research; Behavioral Sciences; Biological Markers; Biological Sciences; Biometry; Body Weight decreased; Candidate Disease Gene; Collection; Communication; Communities; Community Developments; Complex; Data; Data Analyses; Databases; Development; Development Plans; Diet; Dietary Fats; Eating; Educational Curriculum; Energy Intake; Environment; Epidemiology; Exercise; Exhibits; Fatty acid glycerol esters; Funding; Future; Genes; Genetic; Genetic Databases; Genetic Variation; Genotype; Goals; Grant; Health; Individual; Intake; Intervention; Intervention Studies; Island; K-Series Research Career Programs; Knowledge; Lead; Life; Life Style; Manuscripts; Medical; Melanocortin 4 Receptor; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolic Pathway; Methodology; Methods; Minority; Mission; Modality; National Health and Nutrition Examination Survey; National Institute of Nursing Research; Neighborhoods; Not Hispanic or Latino; Obesity; Out-Migrations; Outcome; Overweight; Patient Self-Report; Penetration; Phase; Phenotype; Physical activity; Play; Population; Prevention Research; Production; Protocols documentation; Proxy; Public Health; Public Housing; Qualitative Methods; Randomized Controlled Trials; Registries; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk; Risk Reduction; Role; Sampling; Scientist; Sea; Senior Scientist; Sister; Socioeconomic Status; South Carolina; Stress; Testing; Training; United States; Universities; Weight; Woman; Writing; base; career; career development; community setting; design; diabetes prevention program; ethnic minority population; evidence base; genetic registry; genetic variant; health disparity; improved; innovation; interdisciplinary collaboration; intervention program; lipid metabolism; low density lipoprotein triglyceride; low socioeconomic status; meetings; new technology; novel; novel strategies; nutrition; obesity prevention; obesity treatment; preference; research and development; residence; response; skills; social; socioeconomics; theories; therapy development; treatment response; waist circumference; weight loss intervention

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Development Award proposal is designed to provide the scholarly training, mentorship, and resources necessary for the candidate to develop expertise in bio-behavioral research. The candidate's primary career goal is to become a funded independent investigator and recognized leader in the field of obesity prevention/treatment with expertise in developing personalized bio-behavioral weight loss interventions for African American (AA) women. To achieve this goal, a focused career development plan is proposed to: 1) Obtain knowledge and skills in understanding how genetic variants may be related to adiposity; modulate influence of lifestyle behaviors (i.e.PA, diet) upon changes in adiposity, and how these genotypes may eventually be used to help personalize behavioral interventions for obese AA women; 2) Obtain knowledge and skills in complex quantitative research methods, including bio-behavioral research designs and analyses, and advanced intervention development; and, 3) Enhance grant and scholarly writing skills, and manuscript production while continuing to build interdisciplinary collaboration with other researchers in the field of genetics, obesity and prevention research. The Medical University of South Carolina provides a comprehensive training environment that includes senior scientists with expertise in bio-behavioral interventions, genetics, and health disparities research. The candidate has a strong inter-professional and inter-institutional mentoring team with complementary expertise in the development of community based randomized controlled trials (RCT), genetics, obesity prevention and treatment, bio-behavioral interventions, biostatistics and epidemiology. The research plan, which builds on the training objectives, is directly responsive to the National Institute of Nursing Research's (NINR) mission of integrating the biological and behavioral sciences, employing new technologies to research questions, improving research methods, and developing the scientists of the future. The broad goal of this research is to identify key components for development of efficacious socio-culturally tailored behavioral interventions for long-term weight loss in low socioeconomic status (SES) obese AA women. The socio-cultural preferences will be incorporated into behavioral change strategies, the communication of genetic information, and the adaptation of the format and delivery of the evidence-based Diabetes Prevention Program materials and approaches to promote weight loss. To meet this goal, the candidate will conduct an exploratory study using genetic database secondary data analyses. Secondly, an intervention development phase, with 80 obese AA women living in public housing neighborhoods in the Charleston, SC region, to integrate new knowledge and skills from genetics while advancing skills in bio- behavioral research intervention development and methodology. The results of the proposed preliminary studies will inform a larger, adequately powered and resourced community based RCT for obese AA women that incorporates the use of genetic information and socio-cultural preferences to prescribe tailored weight loss strategies and promote long-term weight loss outcomes.

描述（由申请人提供）：这个K 01指导研究科学家发展奖的建议旨在提供必要的学术培训，导师和资源，为候选人发展生物行为研究的专业知识。候选人的主要职业目标是成为一名受资助的独立调查员和肥胖预防/治疗领域公认的领导者，拥有为非洲裔美国人（AA）女性开发个性化生物行为减肥干预措施的专业知识。为了实现这一目标，提出了一个有针对性的职业发展计划：1）获得了解遗传变异如何与肥胖相关的知识和技能;调节生活方式行为的影响（即PA，饮食）在肥胖的变化，以及如何这些基因型可能最终被用来帮助个性化的行为干预肥胖AA妇女; 2）获得复杂的定量研究方法的知识和技能，包括生物行为研究设计和分析，以及先进的干预开发; 3）提高赠款和学术写作能力，在继续与遗传学、肥胖症和预防研究领域的其他研究人员建立跨学科合作的同时，南卡罗来纳州医科大学提供全面的培训环境，包括在生物行为干预，遗传学和健康差异研究方面具有专业知识的高级科学家。候选人拥有强大的跨专业和跨机构指导团队，在社区随机对照试验（RCT），遗传学，肥胖预防和治疗，生物行为干预，生物统计学和流行病学的发展方面具有互补的专业知识。研究计划，它建立在培训目标，是直接响应国家护理研究所（NINR）的使命整合生物和行为科学，采用新技术研究问题，改进研究方法，并开发未来的科学家。本研究的广泛目标是确定有效的社会文化定制的行为干预措施，长期减肥低社会经济地位（SES）肥胖AA妇女的发展的关键组成部分。社会文化偏好将被纳入行为改变策略，遗传信息的交流，以及以证据为基础的糖尿病预防计划材料和方法的格式和交付的适应，以促进减肥。为了实现这一目标，候选人将使用遗传数据库二级数据分析进行探索性研究。其次，一个干预发展阶段，与80名肥胖的AA妇女生活在公共住房社区的查尔斯顿，南卡罗来纳州地区，整合新的知识和技能，从遗传学，同时推进技能，在生物行为研究干预发展和方法。拟议的初步研究的结果将为肥胖AA女性提供更大的，有足够动力和资源的社区RCT，该RCT结合了遗传信息和社会文化偏好的使用，以制定量身定制的减肥策略并促进长期减肥结果。