New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
符合气溶胶沉积惯例的新个人采样方法
基本信息
- 批准号:8536653
- 负责人:
- 金额:$ 10.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Candidate: My long-term career goal is to become a well qualified, extramurally funded independent researcher that will have an impact in reducing occupational exposure to respiratory hazards. My background is in studies of human aerosol inhalability and personal aerosol sampler performance. I have a PhD in Industrial Health and an MPH in Industrial Hygiene & Hazardous Substances, both from the University of Michigan. I also have 4 first-author peer-reviewed publications and significant experience presenting at international and national conferences and meetings. I am currently a tenure-track Assistant Professor at the University of Utah, Rocky Mountain Center for Occupational & Environmental Health (RMCOEH). Through this proposed K01, I will build on my dissertation and previous experience to transfer it into the development of innovative projects that advance the science of workplace air sampling to better protect worker's health. Career Development Plan: This K01 award will further my goal to be an independent academic researcher by providing an intensive, supervised career development experience in occupational health research leading to research independence. My ultimate career goals are: 1. Develop innovative R01 research proposals 2. Establish a high-quality, extramurally funded research program 3. Provide superior graduate level teaching My Mentor Advisory Committee (see Research Strategy for specific expertise) consists of: 7 Rodney Larson, PhD, CIH (primary mentor; Industrial Hygiene); 7 JoAnn Lighty, PhD (Chemical Engineering); 7 Samuel Paik, PhD, CIH (Industrial Hygiene - Lawrence Livermore National Laboratory); 7 Eric Pardyjak, PhD (Mechanical Engineering); 7 John Veranth, PhD (Pharmacology & Toxicology); and 7 Eric Wood, MD, MPH (Occupational Medicine). My career development plan includes: 1) monthly meetings with my committee, 2) obtaining a Research Investigator Certificate, 3) participating in Journal Clubs, 4) participating in standards setting, 5) technical coursework in Fluid Dynamics, and 6) significant experiential learning. The RMCOEH is a NIOSH-sponsored Education & Research Center (ERC) with well-qualified faculty and significant ties to other academic departments and institutions, relevant industries and government entities. Together with my focused career development plan, this fosters an institutional environment committed to my development into a productive, independent investigator. Research: The goal of this research is to design, develop and test a new personal aerosol sampler that will collect a more biologically-relevant fraction of airborne particulates. This would allow improved quantification of and protection from worker's health risks. A unique aspect of this project will be sampler testing in a specially-designed low speed wind tunnel that simulates indoor exposure scenarios. This environment is more relevant to typical worker exposures than other sampler testing methods and has not been used for sampler development. The research plan is based on the improvement and/or modification of existing personal inhalable aerosol samplers. Most particle size-selective aerosol samplers that are currently used to measure personal exposures in the workplace (i.e., inhalable, thoracic or respirable samplers) are based on criteria established for particle penetration into various portions of the human respiratory tract. In reality, some particles that are inhaled during breathing will be exhaled without deposition into the body. The true biologically-relevant dose would therefore not include the exhaled aerosols. A promising method for a "deposition sampler" involves porous polyurethane foam inserts that act as collection media for particle size selectivity. In the proposed research, this type of foam will be used in series with a commercially-available inhalable aerosol sampler (n=324 samples). In this way, the aspiration efficiency of the sampler (i.e., what size particles it will collect) can be modified by altering the porosity and thickness of the foam. Using t-tests and bias maps, the performance of these sampler prototypes will then be compared to newly-proposed criteria for deposition sampling. Ultimately, this research aims to improve existing sampling techniques in order to provide more biologically-relevant exposure assessment data, which would strengthen the relationship between exposure and disease in epidemiological studies, while also better protecting worker's health.
描述(由申请人提供):候选人:我的长期职业目标是成为一个合格的,校外资助的独立研究人员,将在减少职业暴露于呼吸危害的影响。我的背景是研究人类气溶胶可吸入性和个人气溶胶采样器的性能。我拥有密歇根大学工业健康博士学位和工业卫生与有害物质硕士学位。我还拥有4篇第一作者同行评审的出版物和在国际和国家会议上发表的重要经验。我目前是犹他州大学落基山职业与环境健康中心(RMCOEH)的终身助理教授。通过这个建议的K01,我将建立在我的论文和以前的经验,将其转移到创新项目的发展,推进工作场所空气采样的科学,以更好地保护工人的健康。职业发展计划:这个K01奖将进一步我的目标是通过提供一个密集的,监督职业健康研究的职业发展经验,导致研究的独立性是一个独立的学术研究。我的职业目标是:1。开发创新的R01研究提案2.建立一个高质量的,校外资助的研究计划3。提供上级研究生水平的教学我的导师顾问委员会(见研究战略的具体专业知识)包括:7罗德尼·拉森,博士,CIH(初级导师;工业卫生学); 7 JoAnn Lighty,PhD(化学工程); 7 Samuel Paik,PhD,CIH(工业卫生-劳伦斯利弗莫尔国家实验室); 7 Eric Pardyjak,博士(机械工程); 7 John Veranth,博士(药理学和毒理学);和7 Eric Wood,MD,MPH(职业医学)。我的职业发展计划包括:1)每月与我的委员会开会,2)获得研究员证书,3)参加期刊俱乐部,4)参与标准制定,5)流体动力学技术课程,6)重要的体验式学习。RMCOEH是NIOSH赞助的教育与研究中心(ERC),拥有高素质的教师,并与其他学术部门和机构,相关行业和政府实体有着重要的联系。再加上我的职业发展计划,这促进了一个机构环境,致力于我的发展成为一个富有成效的,独立的调查员。调研:本研究的目标是设计、开发和测试一种新的个人气溶胶采样器,该采样器将收集更多与生物相关的空气颗粒物。这将有助于更好地量化和保护工人免受健康风险。该项目的一个独特之处是在专门设计的低速风洞中进行采样器测试,该风洞模拟室内暴露场景。与其他采样器测试方法相比,这种环境与典型的工人接触更相关,并且尚未用于采样器开发。该研究计划是基于现有的个人可吸入气溶胶采样器的改进和/或修改。目前用于测量工作场所个人暴露的大多数颗粒尺寸选择性气溶胶采样器(即,可吸入的、胸的或可呼吸的采样器)是基于为颗粒渗透到人呼吸道的各个部分中而建立的标准。事实上,在呼吸过程中吸入的一些颗粒将被呼出而不会沉积到体内。因此,真正的生物学相关剂量不包括呼出气溶胶。一个有前途的方法"沉积采样器"涉及多孔聚氨酯泡沫插入物,作为收集介质的粒度选择性。在拟议的研究中,这种类型的泡沫将与市售的可吸入气溶胶采样器(n = 324个样本)串联使用。这样,采样器的抽吸效率(即,它将收集什么尺寸的颗粒)可以通过改变泡沫的孔隙率和厚度来改变。使用t检验和偏差图,这些采样器原型的性能,然后将比较新提出的沉积物采样标准。最终,本研究旨在改进现有的采样技术,以提供更多的生物相关的暴露评估数据,这将加强流行病学研究中暴露与疾病之间的关系,同时也更好地保护工人的健康。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Darrah Kaye Sleeth其他文献
Darrah Kaye Sleeth的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Darrah Kaye Sleeth', 18)}}的其他基金
New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
符合气溶胶沉积惯例的新个人采样方法
- 批准号:
8706127 - 财政年份:2012
- 资助金额:
$ 10.72万 - 项目类别:
New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
符合气溶胶沉积惯例的新个人采样方法
- 批准号:
8223561 - 财政年份:2012
- 资助金额:
$ 10.72万 - 项目类别:
相似海外基金
Generation of novel wireless personal area networks using virtual reality assisted environments.
使用虚拟现实辅助环境生成新型无线个人区域网络。
- 批准号:
24K20764 - 财政年份:2024
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Youth co-design prevention of gendered personal and interpersonal violence in Botswana
博茨瓦纳青年共同设计预防性别个人和人际暴力
- 批准号:
495126 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Operating Grants
The Establishment of Modern Geography in Germany and its Anchoring in Japan; Research on the Personal Collections by Goethe, Rein, and Yamasaki
现代地理学在德国的建立及其在日本的扎根
- 批准号:
23H00597 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Operation support for personal mobility considering the sense of agency based on the estimation of user's intention
基于用户意图估计的考虑代理感的个人移动操作支持
- 批准号:
23K11269 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Explainable Pattern Recognition of Cardiopulmonary Coupling and its Application to Personal Sleep Monitoring
心肺耦合的可解释模式识别及其在个人睡眠监测中的应用
- 批准号:
23K11305 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on Explainable Recommender Systems using Personal Network
使用个人网络的可解释推荐系统研究
- 批准号:
23H03504 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Protection of personal information and data of the deceased
保护死者的个人信息和数据
- 批准号:
23K01217 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development and validation of a Parallel Artificial Membrane Assay Permeation model for personal care formulations
个人护理配方平行人工膜测定渗透模型的开发和验证
- 批准号:
2870236 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Studentship
Supporting Engineering and Computing Studies Scholars through Experiential Learning, Personal Development, and Community Service
通过体验式学习、个人发展和社区服务支持工程和计算机研究学者
- 批准号:
2221052 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Standard Grant
CAREER: Transforming Personal Informatics Systems to Support Routine Transitions in Healthy Eating
职业:转变个人信息系统以支持健康饮食的常规转变
- 批准号:
2414270 - 财政年份:2023
- 资助金额:
$ 10.72万 - 项目类别:
Continuing Grant