New Personal Sampling Methods that Conform to an Aerosol Deposition Convention

符合气溶胶沉积惯例的新个人采样方法

基本信息

  • 批准号:
    8706127
  • 负责人:
  • 金额:
    $ 10.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-01 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Candidate: My long-term career goal is to become a well qualified, extramurally funded independent researcher that will have an impact in reducing occupational exposure to respiratory hazards. My background is in studies of human aerosol inhalability and personal aerosol sampler performance. I have a PhD in Industrial Health and an MPH in Industrial Hygiene & Hazardous Substances, both from the University of Michigan. I also have 4 first-author peer-reviewed publications and significant experience presenting at international and national conferences and meetings. I am currently a tenure-track Assistant Professor at the University of Utah, Rocky Mountain Center for Occupational & Environmental Health (RMCOEH). Through this proposed K01, I will build on my dissertation and previous experience to transfer it into the development of innovative projects that advance the science of workplace air sampling to better protect worker's health. Career Development Plan: This K01 award will further my goal to be an independent academic researcher by providing an intensive, supervised career development experience in occupational health research leading to research independence. My ultimate career goals are: 1. Develop innovative R01 research proposals 2. Establish a high-quality, extramurally funded research program 3. Provide superior graduate level teaching My Mentor Advisory Committee (see Research Strategy for specific expertise) consists of: 7 Rodney Larson, PhD, CIH (primary mentor; Industrial Hygiene); 7 JoAnn Lighty, PhD (Chemical Engineering); 7 Samuel Paik, PhD, CIH (Industrial Hygiene - Lawrence Livermore National Laboratory); 7 Eric Pardyjak, PhD (Mechanical Engineering); 7 John Veranth, PhD (Pharmacology & Toxicology); and 7 Eric Wood, MD, MPH (Occupational Medicine). My career development plan includes: 1) monthly meetings with my committee, 2) obtaining a Research Investigator Certificate, 3) participating in Journal Clubs, 4) participating in standards setting, 5) technical coursework in Fluid Dynamics, and 6) significant experiential learning. The RMCOEH is a NIOSH-sponsored Education & Research Center (ERC) with well-qualified faculty and significant ties to other academic departments and institutions, relevant industries and government entities. Together with my focused career development plan, this fosters an institutional environment committed to my development into a productive, independent investigator. Research: The goal of this research is to design, develop and test a new personal aerosol sampler that will collect a more biologically-relevant fraction of airborne particulates. This would allow improved quantification of and protection from worker's health risks. A unique aspect of this project will be sampler testing in a specially-designed low speed wind tunnel that simulates indoor exposure scenarios. This environment is more relevant to typical worker exposures than other sampler testing methods and has not been used for sampler development. The research plan is based on the improvement and/or modification of existing personal inhalable aerosol samplers. Most particle size-selective aerosol samplers that are currently used to measure personal exposures in the workplace (i.e., inhalable, thoracic or respirable samplers) are based on criteria established for particle penetration into various portions of the human respiratory tract. In reality, some particles that are inhaled during breathing will be exhaled without deposition into the body. The true biologically-relevant dose would therefore not include the exhaled aerosols. A promising method for a "deposition sampler" involves porous polyurethane foam inserts that act as collection media for particle size selectivity. In the proposed research, this type of foam will be used in series with a commercially-available inhalable aerosol sampler (n=324 samples). In this way, the aspiration efficiency of the sampler (i.e., what size particles it will collect) can be modified by altering the porosity and thickness of the foam. Using t-tests and bias maps, the performance of these sampler prototypes will then be compared to newly-proposed criteria for deposition sampling. Ultimately, this research aims to improve existing sampling techniques in order to provide more biologically-relevant exposure assessment data, which would strengthen the relationship between exposure and disease in epidemiological studies, while also better protecting worker's health.
应聘者描述:应聘者:我的长期职业目标是成为一名合格的、有外部资助的独立研究人员,这将对减少职业暴露于呼吸道危害产生影响。我的背景是研究人体气溶胶的可吸入性和个人气溶胶采样器的性能。我拥有密歇根大学的工业健康博士学位和工业卫生与危险物质公共卫生硕士学位。我还拥有4份第一作者、同行评议的出版物,以及在国际和国家会议上发表演讲的丰富经验。我目前是犹他大学落基山职业与环境健康中心(RMCOEH)的终身教职助理教授。通过这个提议的K01,我将在我的论文和以前的经验的基础上,将其转化为创新项目的开发,以促进工作场所空气采样的科学,以更好地保护工人的健康。职业发展计划:这一K01奖项将通过提供职业健康研究方面密集的、受监督的职业发展经验来推动我成为一名独立的学术研究人员的目标,从而实现研究的独立性。我的最终职业目标是:1.开发创新的R01研究计划2.建立高质量的外部资助的研究计划3.提供优秀的研究生水平教学我的导师咨询委员会(具体专业知识请参阅研究战略)由以下人员组成:7罗德尼·拉尔森博士,CIH(主要导师;工业卫生);7乔安·莱特,博士(化学工程);7 Samuel Paik,博士,CIH(工业卫生-劳伦斯·利弗莫尔国家实验室);7 Eric Pardyjak博士(机械工程);7 John Veranth博士(药理学和毒物学);7 Eric Wood,医学博士,公共卫生硕士(职业医学)。我的职业发展计划包括:1)每月与我的委员会开会,2)获得研究人员证书,3)参加杂志俱乐部,4)参与标准制定,5)流体动力学技术课程,6)重要的体验式学习。RMCOEH是由NIOSH赞助的教育与研究中心(ERC),拥有高素质的教师队伍,并与其他学术部门和机构、相关行业和政府实体建立了密切的联系。再加上我专注的职业发展计划,这将为我提供一个致力于将我发展成为一名富有成效的独立调查员的制度环境。研究:这项研究的目标是设计、开发和测试一种新的个人气溶胶采样器,它将收集更多与生物相关的空气颗粒物。这将改善对工人健康风险的量化和保护。该项目的一个独特方面是在一个特别设计的低速风洞中进行取样器测试,该风洞模拟室内暴露场景。与其他采样器测试方法相比,这种环境与典型的工人暴露更相关,并且尚未用于采样器的开发。该研究计划基于对现有个人可吸入气溶胶采样器的改进和/或改进。目前用于测量工作场所个人暴露量的大多数选择颗粒大小的气溶胶采样器(即可吸入、胸部或呼吸采样器)都是基于为颗粒物渗透到人体呼吸道不同部位而建立的标准。事实上,一些在呼吸过程中被吸入的颗粒物会被呼出,而不会沉积到体内。因此,真正与生物相关的剂量不包括呼出的气雾剂。一种很有前途的“沉积取样器”方法是使用多孔的聚氨酯泡沫塑料作为颗粒大小选择性的收集介质。在拟议的研究中,这种类型的泡沫将与商业上可获得的可吸入气溶胶采样器(n=324个样品)串联使用。通过这种方式,可以通过改变泡沫的孔隙率和厚度来改变取样器的吸入效率(即,它将收集多大尺寸的颗粒)。使用t检验和偏差图,然后将这些取样器原型的性能与新提出的沉积取样标准进行比较。最终,这项研究旨在改进现有的抽样技术,以便提供更多与生物相关的暴露评估数据,从而在流行病学研究中加强暴露与疾病之间的关系,同时也更好地保护工人的健康。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The effects of neutralized particles on the sampling efficiency of polyurethane foam used to estimate the extrathoracic deposition fraction.
中和颗粒对用于估计胸外沉积分数的聚氨酯泡沫采样效率的影响。
Estimation of the Human Extrathoracic Deposition Fraction of Inhaled Particles Using a Polyurethane Foam Collection Substrate in an IOM Sampler.
使用 IOM 采样器中的聚氨酯泡沫收集基质估算人体吸入颗粒的胸腔外沉积分数。
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Darrah Kaye Sleeth其他文献

Darrah Kaye Sleeth的其他文献

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{{ truncateString('Darrah Kaye Sleeth', 18)}}的其他基金

New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
符合气溶胶沉积惯例的新个人采样方法
  • 批准号:
    8223561
  • 财政年份:
    2012
  • 资助金额:
    $ 10.69万
  • 项目类别:
New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
符合气溶胶沉积惯例的新个人采样方法
  • 批准号:
    8536653
  • 财政年份:
    2012
  • 资助金额:
    $ 10.69万
  • 项目类别:

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