Role of BDNF on Risk Behavior Decision Making

BDNF 在风险行为决策中的作用

• 批准号: 8519139
• 负责人: Maria-Jose Miguez
• 金额: $ 42.79万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519139
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Risk Behavior; Adult; Affect; Affective; African American; Age; Alcohols; Animals; Anxiety; Applications Grants; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain-Derived Neurotrophic Factor; Childhood; Clinical; Cognitive; Coitus; Competence; Complex; County; Data; Decision Making; Development; Dimensions; Discrimination; Disease; Distress; Down-Regulation; Drug usage; Ensure; Environment; Environmental Risk Factor; Epidemic; Evaluation; Family; Florida; Goals; HIV; HIV risk; Health; Heavy Drinking; Hispanics; Human; Impulsivity; Individual; Institution; International; Intervention; Investigation; Knowledge; Life; Life Experience; Link; Longitudinal Studies; Measurement; Mediating; Mental Depression; Minority; Modeling; Moods; Nature; Neurobiology; Neuromodulator; New York; Outcome; Participant; Personal Satisfaction; Plasma; Population; Poverty; Prevalence; Primates; Problem behavior; Process; Questionnaires; Recombinants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Role; Seroprevalences; Site; Solutions; Staging; Stress; Subgroup; Surveys; Testing; Therapeutic; Time; United States; Universities; Withdrawal; Work; Youth; addiction; base; biological adaptation to stress; cofactor; cognitive function; computerized; condoms; decision-making capacity; design; ethnic minority population; executive function; follow-up; heuristics; high risk; information gathering; inner city; innovation; interdisciplinary collaboration; neglect; neurochemistry; neuromechanism; neuropsychological; neurotrophic factor; novel; pressure; psychologic; psychosocial; resilience; sex risk; social; social separation; statistics; success; theories; therapeutic target; therapy design; transmission process; twelfth grade

This proposed R01 is a 5-year longitudinal bio-psycho-social integrative study of inner-city Hispanic adolescents, designed as a proof-of-concept of the neglected role of the neuromodulator BDNF (brain derived neurotrophic factor) in decision making (DM) and HIV-Transmission Risk Behaviors (TRBs). In addition to promising preliminary research findings, the impetus for this proposal is Hispanic seroprevalence in Florida, which is nearly twice the national rate. Long a primary U.S. epicenter, the latest available data shows that Florida¿s HIV epidemic is unexpectedly grim, ranking 3rd in cumulative AIDS cases, 2nd in cumulative pediatric cases. Because of heightened risk-taking, adolescents are considered among the high-risk HIV subgroups. Moreover, among 34 states in 2007, Florida ranked 2nd (behind New York) in the number of adolescents (13 to 19 years) living with HIV/AIDS, with the highest concentration in S. Florida¿s Miami-Dade and Broward counties, the sites of this proposal. This highlights the urgency for enhancing current understanding of risk and vulnerability factors in these minority subpopulations, particularly neurobiological factors that have been largely neglected in prior work and rarely examined in ethnic minority adolescents. The proposed study tests a theory-grounded- decision making model among Hispanic adolescents, which emphasizes the neuromodulator BDNF, extending its evaluation from alcohol/drug use to sexual risk behavior, in a framework that hypothesizes that disturbances are likely to: a) alter cognitive process; b) link to complex behaviors such as decision making and adaptation; and c) be highly relevant to problems in maintaining psychological well-being, particularly under stressful situations. The study also aims to explore the interaction of family/environment with adolescents¿ neurobiochemical factors in affecting HIV-TRBs given its pivotal role during adolescent brain development, and DM. With the support of local Health Departments, we propose to recruit 500 Hispanic adolescents (13-16 years), with follow-up over two years (3 time points) to examine the inter-relationships of biological and neuropsychological factors, and life experiences on HIV-TRBs, and to capture transition to later developmental stages. The proposed project is a transdisciplinary collaboration that will contribute new bio-behavioral knowledge to target neural mechanisms for which clinical solutions already exist. Treatments are currently available that may ameliorate suboptimal neurochemical levels (e.g., recombinant BDNF). In addition, because BDNF is implicated in both affective and cognitive dimensions of decision making, the proposed study also offers an innovative strategy for the highly sought-ever goal of integrating neurobiology into behavioral interventions among these susceptible populations.

本研究是一项为期5年的纵向生物-心理-社会整合研究，研究对象是市中心的西班牙裔美国人。 青少年，设计作为被忽视的作用的神经调质BDNF（脑 衍生的神经营养因子）在决策（DM）和艾滋病毒传播风险行为（TRB）。在 除了有希望的初步研究结果外，这项提案的推动力是西班牙裔 佛罗里达的血清阳性率几乎是全国的两倍长期以来一直是美国的主要震中，最近一次 现有数据显示，佛罗里达州的艾滋病疫情出乎意料地严峻，在累计艾滋病疫情中排名第三， 例，累计儿科病例第2位。由于高风险，青少年被认为是 艾滋病高危人群中。此外，在2007年的34个州中，佛罗里达排名第二（仅次于新 约克）感染艾滋病毒/艾滋病的青少年（13至19岁）人数最多， S.佛罗里达州的迈阿密-戴德县和布劳沃德县，这一建议的网站。这突出表明， 加强目前对这些少数群体的风险和脆弱性因素的了解， 特别是神经生物学因素，这些因素在以前的工作中很大程度上被忽视， 少数民族青少年。该研究测试了一个基于理论的决策模型， 西班牙裔青少年，强调神经调质BDNF，从 酒精/药物使用对性风险行为的影响，在一个假设干扰可能： a）改变认知过程; B）与决策和适应等复杂行为联系起来; c） 与维持心理健康的问题高度相关，特别是在压力情况下。 这项研究还旨在探讨家庭/环境与青少年神经生化的相互作用。 影响HIV-TRB的因素，因为它在青少年大脑发育和DM中起着关键作用。与 在当地卫生部门的支持下，我们计划招募500名西班牙裔青少年（13-16岁）， 随访2年（3个时间点），以检查生物学和 神经心理学因素和生活经验对艾滋病毒的TRB，并捕捉过渡到后来 发育阶段拟议的项目是一个跨学科的合作，将有助于新的 生物行为知识，以针对已经存在的临床解决方案的神经机制。 目前可用的治疗可以改善次优的神经化学水平（例如，重组 BDNF）。此外，由于BDNF与决策的情感和认知维度有关， 此外，这项研究还提出了一个创新的战略， 在这些易感人群中进行行为干预。