Role of BDNF on Risk Behavior Decision Making

BDNF 在风险行为决策中的作用

• 批准号: 8258577
• 负责人: Maria-Jose Miguez
• 金额: $ 50.52万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8258577
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Risk Behavior; Adult; Affect; Affective; African American; Age; Alcohols; Animals; Anxiety; Applications Grants; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain-Derived Neurotrophic Factor; Childhood; Clinical; Cognitive; Coitus; Competence; Complex; County; Data; Decision Making; Development; Dimensions; Discrimination; Disease; Distress; Down-Regulation; Drug usage; Ensure; Environment; Environmental Risk Factor; Epidemic; Evaluation; Family; Florida; Goals; HIV; Health; Heavy Drinking; Hispanics; Human; Impulsivity; Individual; Institution; International; Intervention; Investigation; Knowledge; Life; Life Experience; Link; Longitudinal Studies; Measurement; Mediating; Mental Depression; Minority; Modeling; Moods; Nature; Neurobiology; Neuromodulator; New York; Outcome; Participant; Personal Satisfaction; Plasma; Population; Poverty; Prevalence; Primates; Problem behavior; Process; Questionnaires; Recombinants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Role; Seroprevalences; Site; Solutions; Staging; Stress; Subgroup; Surveys; Testing; Therapeutic; Time; United States; Universities; Withdrawal; Work; Youth; addiction; base; biological adaptation to stress; cofactor; cognitive function; computerized; condoms; decision-making capacity; design; ethnic minority population; executive function; follow-up; heuristics; high risk; information gathering; inner city; innovation; interdisciplinary collaboration; neglect; neurochemistry; neuromechanism; neuropsychological; neurotrophic factor; novel; pressure; psychologic; psychosocial; resilience; sex risk; social; social separation; statistics; success; theories; therapeutic target; therapy design; transmission process

DESCRIPTION (provided by applicant): This proposed R01 is a 5-year longitudinal bio-psycho-social integrative study of inner-city Hispanic adolescents, designed as a proof-of-concept of the neglected role of the neuromodulator BDNF (brain derived neurotrophic factor) in decision making (DM) and HIV-Transmission Risk Behaviors (TRBs). In addition to promising preliminary research findings, the impetus for this proposal is Hispanic seroprevalence in Florida, which is nearly twice the national rate. Long a primary U.S. epicenter, the latest available data shows that Florida's HIV epidemic is unexpectedly grim, ranking 3rd in cumulative AIDS cases, 2nd in cumulative pediatric cases. Because of heightened risk-taking, adolescents are considered among the high-risk HIV subgroups. Moreover, among 34 states in 2007, Florida ranked 2nd (behind New York) in the number of adolescents (13 to 19 years) living with HIV/AIDS, with the highest concentration in S. Florida's Miami-Dade and Broward counties, the sites of this proposal. This highlights the urgency for enhancing current understanding of risk and vulnerability factors in these minority subpopulations, particularly neurobiological factors that have been largely neglected in prior work and rarely examined in ethnic minority adolescents. The proposed study tests a theory-grounded- decision making model among Hispanic adolescents, which emphasizes the neuromodulator BDNF, extending its evaluation from alcohol/drug use to sexual risk behavior, in a framework that hypothesizes that disturbances are likely to: a) alter cognitive process; b) link to complex behaviors such as decision making and adaptation; and c) be highly relevant to problems in maintaining psychological well-being, particularly under stressful situations. The study also aims to explore the interaction of family/environment with adolescents' neurobiochemical factors in affecting HIV-TRBs given its pivotal role during adolescent brain development, and DM. With the support of local Health Departments, we propose to recruit 500 Hispanic adolescents (13-16 years), with follow-up over two years (3 time points) to examine the inter-relationships of biological and neuropsychological factors, and life experiences on HIV-TRBs, and to capture transition to later developmental stages. The proposed project is a transdisciplinary collaboration that will contribute new bio-behavioral knowledge to target neural mechanisms for which clinical solutions already exist. Treatments are currently available that may ameliorate suboptimal neurochemical levels (e.g., recombinant BDNF). In addition, because BDNF is implicated in both affective and cognitive dimensions of decision making, the proposed study also offers an innovative strategy for the highly sought-ever goal of integrating neurobiology into behavioral interventions among these susceptible populations.

描述（由申请人提供）：这项拟议的R 01是一项针对市中心西班牙裔青少年的5年纵向生物-心理-社会综合研究，旨在验证神经调节剂BDNF（脑源性神经营养因子）在决策（DM）和HIV传播风险行为（TRB）中被忽视的作用的概念。除了有希望的初步研究结果，这一提议的动力是西班牙裔血清阳性率在佛罗里达，这是近两倍的全国率。长期以来一直是美国的主要震中，最新的数据显示，佛罗里达的艾滋病疫情出人意料地严峻，艾滋病累计病例排名第三，儿科累计病例排名第二。由于冒险行为增加，青少年被视为艾滋病毒高风险亚群。此外，在2007年的34个州中，佛罗里达在青少年（13至19岁）感染艾滋病毒/艾滋病的人数方面排名第二（仅次于纽约），其中最高的是南卡罗来纳州。佛罗里达的迈阿密-戴德县和布劳沃德县，这一建议的网站。这突出了加强对这些少数民族亚群的风险和脆弱性因素的认识的紧迫性，特别是在以前的工作中基本上被忽视的神经生物学因素，很少在少数民族青少年中进行检查。这项研究在西班牙裔青少年中测试了一个基于理论的决策模型，该模型强调神经调节剂BDNF，将其评估从酒精/药物使用扩展到性风险行为，在一个假设干扰可能的框架内：a）改变认知过程; B）与决策和适应等复杂行为有关;以及c）与维持心理健康的问题高度相关，特别是在压力情况下。该研究还旨在探讨家庭/环境与青少年神经生化因素在影响HIV-TRB方面的相互作用，因为它在青少年大脑发育和DM中起着关键作用。在当地卫生部门的支持下，我们建议招募500名西班牙裔青少年（13-16岁），随访超过两年（3个时间点），以检查生物学和神经心理学因素之间的相互关系，以及HIV-TRB的生活经历，并捕捉向后期发展阶段的过渡。拟议的项目是一个跨学科的合作，将有助于新的生物行为知识，以目标神经机制，临床解决方案已经存在。目前可用的治疗可以改善次优的神经化学水平（例如，重组BDNF）。此外，由于BDNF与决策的情感和认知维度有关，因此该研究还为将神经生物学整合到这些易感人群的行为干预中这一备受追捧的目标提供了一种创新策略。