Role of BDNF on Risk Behavior Decision Making

BDNF 在风险行为决策中的作用

• 批准号: 8339363
• 负责人: Maria-Jose Miguez
• 金额: $ 46.87万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8339363
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Risk Behavior; Adult; Affect; Affective; African American; Age; Alcohols; Animals; Anxiety; Applications Grants; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain-Derived Neurotrophic Factor; Childhood; Clinical; Cognitive; Coitus; Competence; Complex; County; Data; Decision Making; Development; Dimensions; Discrimination; Disease; Distress; Down-Regulation; Drug usage; Ensure; Environment; Environmental Risk Factor; Epidemic; Evaluation; Family; Florida; Goals; HIV; Health; Heavy Drinking; Hispanics; Human; Impulsivity; Individual; Institution; International; Intervention; Investigation; Knowledge; Life; Life Experience; Link; Longitudinal Studies; Measurement; Mediating; Mental Depression; Minority; Modeling; Moods; Nature; Neurobiology; Neuromodulator; New York; Outcome; Participant; Personal Satisfaction; Plasma; Population; Poverty; Prevalence; Primates; Problem behavior; Process; Questionnaires; Recombinants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Role; Seroprevalences; Site; Solutions; Staging; Stress; Subgroup; Surveys; Testing; Therapeutic; Time; United States; Universities; Withdrawal; Work; Youth; addiction; base; biological adaptation to stress; cofactor; cognitive function; computerized; condoms; decision-making capacity; design; ethnic minority population; executive function; follow-up; heuristics; high risk; information gathering; inner city; innovation; interdisciplinary collaboration; neglect; neurochemistry; neuromechanism; neuropsychological; neurotrophic factor; novel; pressure; psychologic; psychosocial; resilience; sex risk; social; social separation; statistics; success; theories; therapeutic target; therapy design; transmission process

This proposed R01 is a 5-year longitudinal bio-psycho-social integrative study of inner-city Hispanic adolescents, designed as a proof-of-concept of the neglected role of the neuromodulator BDNF (brain derived neurotrophic factor) in decision making (DM) and HIV-Transmission Risk Behaviors (TRBs). In addition to promising preliminary research findings, the impetus for this proposal is Hispanic seroprevalence in Florida, which is nearly twice the national rate. Long a primary U.S. epicenter, the latest available data shows that Florida¿s HIV epidemic is unexpectedly grim, ranking 3rd in cumulative AIDS cases, 2nd in cumulative pediatric cases. Because of heightened risk-taking, adolescents are considered among the high-risk HIV subgroups. Moreover, among 34 states in 2007, Florida ranked 2nd (behind New York) in the number of adolescents (13 to 19 years) living with HIV/AIDS, with the highest concentration in S. Florida¿s Miami-Dade and Broward counties, the sites of this proposal. This highlights the urgency for enhancing current understanding of risk and vulnerability factors in these minority subpopulations, particularly neurobiological factors that have been largely neglected in prior work and rarely examined in ethnic minority adolescents. The proposed study tests a theory-grounded- decision making model among Hispanic adolescents, which emphasizes the neuromodulator BDNF, extending its evaluation from alcohol/drug use to sexual risk behavior, in a framework that hypothesizes that disturbances are likely to: a) alter cognitive process; b) link to complex behaviors such as decision making and adaptation; and c) be highly relevant to problems in maintaining psychological well-being, particularly under stressful situations. The study also aims to explore the interaction of family/environment with adolescents¿ neurobiochemical factors in affecting HIV-TRBs given its pivotal role during adolescent brain development, and DM. With the support of local Health Departments, we propose to recruit 500 Hispanic adolescents (13-16 years), with follow-up over two years (3 time points) to examine the inter-relationships of biological and neuropsychological factors, and life experiences on HIV-TRBs, and to capture transition to later developmental stages. The proposed project is a transdisciplinary collaboration that will contribute new bio-behavioral knowledge to target neural mechanisms for which clinical solutions already exist. Treatments are currently available that may ameliorate suboptimal neurochemical levels (e.g., recombinant BDNF). In addition, because BDNF is implicated in both affective and cognitive dimensions of decision making, the proposed study also offers an innovative strategy for the highly sought-ever goal of integrating neurobiology into behavioral interventions among these susceptible populations.

建议的R01是一项对市中心拉美裔进行的为期5年的纵向生物-心理-社会综合研究 青少年，旨在证明神经调节剂BDNF(大脑)被忽视的作用 衍生神经营养因子)在决策(DM)和艾滋病毒传播危险行为(TRBs)。在……里面 除了有希望的初步研究结果外，这一提议的推动力是西班牙裔 佛罗里达州的血清阳性率几乎是全国的两倍。长期以来一直是美国的主要震中，最新 可获得的数据显示，佛罗里达州S艾滋病疫情出人意料地严峻，在累计艾滋病人数中排名第三 2例，在儿科累计病例中居第2位。由于冒险行为加剧，青少年被认为是 在高危艾滋病毒亚群中。此外，在2007年的34个州中，佛罗里达州排名第二(落后于纽约州 纽约)感染艾滋病毒/艾滋病的青少年(13至19岁)人数最多的是#年 美国佛罗里达州S迈阿密-戴德县和布罗沃德县，这项提议的地点。这突显了 加强目前对这些少数群体中的风险和脆弱性因素的了解， 特别是神经生物学因素，这些因素在以前的工作中基本上被忽视了，很少在 少数民族青少年。这项拟议的研究测试了一个有理论基础的决策模型 西班牙裔青少年，强调神经调节剂BDNF，将其评估从 酒精/毒品的使用与性危险行为的关系，在一个假设干扰可能会： A)改变认知过程；b)与决策和适应等复杂行为相联系；c) 与保持心理健康的问题高度相关，特别是在压力较大的情况下。 本研究还旨在探讨家庭/环境与青少年神经生化的相互作用 影响艾滋病毒-TRBs的因素，因为它在青少年大脑发育过程中起着关键作用，以及糖尿病。与 在当地卫生部门的支持下，我们建议招募500名西班牙裔青少年(13-16岁)，其中 随访超过两年(3个时间点)，以检查生物学和 关于HIV-TRBs的神经心理因素和生活经历，并捕捉到向后过渡 发育阶段。拟议的项目是一个跨学科的合作，将为 生物行为知识，以临床解决方案已经存在的神经机制为目标。 目前有可改善次优神经化学水平的治疗方法(例如，重组 BDNF)。此外，因为BDNF涉及决策的情感和认知两个维度 这项拟议的研究还为人们热切期盼的整合目标提供了一种创新战略 将神经生物学纳入这些易感人群的行为干预。