Timeliness of Symptom Recognition, Interpretation, and Reporting in Heart Failure

项目总结（见说明）： 这个K99/R 00奖将为里德博士提供指导性的研究经验，以取得成功，作为一个独立的研究者。里德博士的研究项目旨在改善心血管疾病患者的自我管理和临床护理结果，心血管疾病是美国的头号杀手。K99/R 00指导的研究活动将支持1）实施临床研究，以探索成年心力衰竭（HF）患者如何识别、解释和报告症状; 2）验证内容 并使用新的贝叶斯分析对HF症状识别、解释和报告的理论和临床为基础的访谈问卷的结构效度进行评估; 3）关于HF自我管理的知识的进步;以及4）制定研究建议，以经验性地检查基于K99/R 00研究结果的循证干预的效果。拟议的教育活动将为里德博士提供新的知识，以开发一个独立的研究计划，以改善心血管疾病患者的预后。在ROO阶段。博士 里德将应用这些知识，使用她的K99问卷数据与她导师的NHLBI HF临床试验的纵向数据合并，进行独立的二次分析。基于她的论文，评估社会互动对急性心肌梗死院前延迟的影响，里德博士将使用探索性描述性设计，通过采用创新的数据收集日重建方法和新颖的贝叶斯分析来研究症状识别、解释和报告。最终目标是一个独立的研究项目，以促进心血管疾病的有效自我管理，提高护理质量，降低成本。

PROJECT SUMMARY (See instructions): This K99/R00 award will provide mentored research experiences for Dr. Reeder to achieve success as an independent investigator. Dr. Reeder's program of research is aimed at improving self-management and clinical care outcomes of patients with cardiovascular disease, the nation's number-one killer. K99/R00 mentored research activities will support 1) implementation of a clinical research study to explore how adult patients living with heart failure (HF) recognize, interpret, and report symptoms; 2) verification of the content and construct validity of a theoretical and clinically-based interview questionnaire on HF symptom recognition, interpretation, and reporting using novel Bayesian analyses; 3) advancement of knowledge about self-management of HF; and 4) development a research proposal to examine empirically the effect of an evidence-based intervention informed by findings from this K99/R00 study. Proposed educational activities will provide Dr. Reeder with new knowledge integral to developing an independent program of research to improve outcomes for people living with cardiovascular diseases. During the ROO phase. Dr. Reeder will apply this knowledge, conducting an independent secondary analysis, using her K99 questionnaire data merged with longitudinal data from her mentor's NHLBI HF clinical trial. Building on her dissertation that evaluated the influences of social interactions on pre-hospital delay in acute myocardial infarction, Dr. Reeder wiil use an exploratory descriptive design to investigate symptom recognition, interpretation, and reporting by employing both the innovative Day Reconstruction Method for data collection and novel Bayesian analysis. The ultimate goal is an independent program of research to promote effective self-management of cardiovascular diseases, enhance quality of care, and reduce costs.