Timeliness of Symptom Recognition, Interpretation, and Reporting in Heart Failure

描述（由申请人提供）：这个K99/R00奖将为Reeder博士提供教育和指导研究学习经验，使其成为一名成功的独立研究者。里德博士的研究项目旨在改善心血管疾病患者的自我管理和临床护理结果，心血管疾病是美国的头号杀手。K99/R00课程和指导的研究活动将支持1)实施临床研究，探索成年心力衰竭患者如何识别、解释和报告症状；2)使用新颖的贝叶斯分析验证心力衰竭症状识别、解释和报告的理论和临床访谈问卷的内容和构建效度；3)提高心力衰竭自我管理的知识。在症状识别、解释和报告方面，以及4)制定和提交未来的干预研究建议，以K99/R00研究结果为基础，实证检验基于证据的干预措施对心衰结局的影响。Reeder博士拥有强大的研究支持和培训，包括Carol Smith博士，注册护士，教授，KU- son和预防医学导师，拥有连续23年的nih资助研究和长期指导研究生，住院医生，博士后研究员和初级教师的历史，他们已经成为成功的独立研究人员，以及共同导师Byron Gajewski博士，生物统计学系副教授。在该奖项的K99阶段，Reeder博士还将得到3位重要贡献者的支持，一位国际知名的卫生保健经济学家和结果研究员，一位拥有广泛NIH结果研究资金的心脏病专家，以及一位模范的数据库开发专家。里德博士的许多研究开发活动将借鉴KUMC的跨学科研究开发项目、资源和研讨会。拟议的教育活动将为Reeder博士提供新的知识，以发展一个独立的研究项目，改善心血管疾病患者的预后。Dr. Reeder将在一项名为“心衰症状识别、解释和报告的及时性”的临床研究中应用这些知识，作为她的学术研究论文和目前职位的逻辑进展。她的博士论文评估了社会互动对急性心肌梗死（AMI）院前延迟的影响，在此基础上，Reeder博士将使用探索性描述性设计来研究症状识别、解释和报告，方法包括采用创新的日重建方法进行数据收集和新颖的贝叶斯分析。最终目标是一个独立的研究项目，以促进心血管疾病的有效自我管理，提高护理质量，降低成本。

DESCRIPTION (provided by applicant): This K99/R00 award will provide education and mentored research study experiences for Dr. Reeder to achieve success as an independent investigator. Dr. Reeder's program of research is aimed at improving self- management and clinical care outcomes of patients with cardiovascular disease, the nation's number-one killer. K99/R00 coursework and mentored research activities will support 1) implementation of a clinical research study to explore how adult patients living with heart failure (HF) recognize, interpret, and report symptoms, 2) verification of the content and construct validity of a theoretical and clinically-based interview questionnaire on HF symptom recognition, interpretation, and reporting using novel Bayesian analyses, 3) advancement of knowledge about self-management of HF, with respect to symptom recognition, interpretation, and reporting, and 4) development and submission of a future intervention research proposal to examine empirically the effect of an evidence-based intervention that is informed by findings from this K99/R00 study on HF outcomes. Dr. Reeder has strong research support and training from a team that includes Carol Smith, PhD, RN, professor, KU-SON and Preventive Medicine, mentor, with 23 consecutive years of NIH-funded research and a long history of mentoring graduate students, medical residents, post doctoral fellows, and junior faculty who have become successful independent researchers, and co-mentor, Byron Gajewski, PhD, associate professor, KU Department of Biostatistics. During the K99 phase of the award, Dr. Reeder will also have the support of 3 significant contributors, an internationally known health care economist and outcomes researcher, a cardiologist with extensive NIH outcomes research funding, and an exemplary data base development specialist. Many of Dr. Reeder's research development activities will draw from KUMC's interdisciplinary research development programs, resources, and seminars. Proposed educational activities will provide Dr. Reeder with new knowledge integral to developing an independent program of research to improve outcomes for people living with cardiovascular diseases. Dr. Reeder will apply this knowledge through corresponding mentored research activities within a clinical research study, entitled "Timeliness of Symptom Recognition, Interpretation, and Reporting in HF," as a logical progression of her academic research dissertation and current position. Building on her doctoral dissertation that evaluated the influences of social interactions on pre-hospital delay in acute myocardial infarction (AMI), Dr. Reeder will use an exploratory descriptive design to investigate symptom recognition, interpretation, and reporting by employing both the innovative Day Reconstruction Method for data collection and novel Bayesian analysis. The ultimate goal is an independent program of research to promote effective self-management of cardiovascular diseases, enhance quality of care, and reduce costs. PUBLIC HEALTH RELEVANCE: The relevance of this research to public health priorities is that it explores patients' self-management methods used to monitor their bodily changes and symptoms and the timeliness of reporting heart failure symptoms to health care providers. Understanding patient methods can help health care providers to identify ways improve heart failure status and reduce untimely, repeated heart failure hospitalizations.