Training in Endocrinology, Diabetes, Clinical Nutrition

内分泌学、糖尿病、临床营养学培训

• 批准号: 8507716
• 负责人: ROBERT FREDERICK KLEIN
• 金额: $ 25.62万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8507716
• 关键词: Clinical Nutrition; Diabetes Mellitus; Endocrinology; Training

DESCRIPTION (provided by applicant): This application proposes continued support of a successful research-based training program in Endocrinology and Metabolism at Oregon Health & Science University. The main goal of this program, now in its 14th year, is to prepare qualified trainees for successful scientific careers as independent investigators by providing intensive training in hypothesis-driven, basic and disease-oriented research in a stimulating and collegial academic environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. Successful MD candidates will have completed residency training as well as a first, clinical year of endocrine fellowship training prior to enrolling in this program. This requirement allows both MD and PhD trainees to devote at least 80% of their time to first hand experience and training in hypothesis-driven endocrine research under the supervision of an established successful investigator. Research activities will be supplemented by weekly journal clubs, research-in-progress meetings, endocrine research grand rounds, and by formal graduate level course work tailored to the individual scientific needs of each trainee. The special strengths of this program include: 1) The diverse skills and research interests of the faculty in a wide variety of areas including growth factors, thyroid, pituitary, adrenal, signal transduction, molecular genetics, diabetes, obesity, bone and mineral metabolism, lipid disorders, metabolic derangements and reproductive endocrinology. 2) The substantial laboratory resources of the faculty and recently expanded clinical research resources of the OHSU Clinical and Translational Research Center, which facilitates training in state-of-the-art clinical investigation. 3) The outstanding environment for research in both clinical as well as cellular and molecular endocrinology and related areas at OHSU and its affiliated institutions (Vollum Institute and Oregon National Primate Research Center). A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades and is critical for continued advancements in human health care.

描述（由申请人提供）： 该申请建议继续支持俄勒冈州健康与科学大学内分泌学和代谢学的成功研究培训计划。该计划的主要目标，现在在其第14个年头，是准备合格的学员成功的科学事业作为独立的调查人员，通过提供强化培训假设驱动，基础和疾病为导向的研究在一个刺激和学院的学术环境。潜在的候选人将持有MD，MD/PhD或PhD学位。成功的医学博士候选人将完成住院医师培训，以及第一，临床一年的内分泌奖学金培训之前，报名参加这个计划。这一要求允许MD和PhD学员在既定的成功研究者的监督下，将至少80%的时间用于假设驱动的内分泌研究的第一手经验和培训。研究活动将通过每周的期刊俱乐部，研究进展会议，内分泌研究大轮，并根据每个学员的个人科学需求量身定制的正式研究生水平的课程工作来补充。该计划的特殊优势包括：1）教师在各种领域的多样技能和研究兴趣，包括生长因子，甲状腺，垂体，肾上腺，信号转导，分子遗传学，糖尿病，肥胖，骨和矿物质代谢，脂质紊乱，代谢紊乱和生殖内分泌学。2)教师的大量实验室资源和最近扩大的OHSU临床和转化研究中心的临床研究资源，这有利于最先进的临床研究培训。3)OHSU及其附属机构（Vollum Institute和俄勒冈州国家灵长类动物研究中心）在临床以及细胞和分子内分泌学和相关领域的研究环境出色。培训计划的一个主要前提是，对熟练的医生调查人员的需求在未来几十年只会继续增加，这对人类医疗保健的持续进步至关重要。

项目成果

Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.

• DOI: 10.1002/jbmr.2446
• 发表时间: 2015-02
• 期刊: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
• 作者: Swanson CM;Shea SA;Stone KL;Cauley JA;Rosen CJ;Redline S;Karsenty G;Orwoll ES
• 通讯作者: Orwoll ES

Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains.

钙/钙调蛋白依赖性蛋白激酶激酶：调节域的鉴定。

• DOI: 10.1021/bi971348i
• 发表时间: 1997
• 期刊: Biochemistry.
• 作者: Tokumitsu,H;Wayman,GA;Muramatsu,M;Soderling,TR
• 通讯作者: Soderling,TR

Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes.

• DOI: 10.2337/dc09-2254
• 发表时间: 2010-06
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Castle JR;Engle JM;El Youssef J;Massoud RG;Yuen KC;Kagan R;Ward WK
• 通讯作者: Ward WK

A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes.

一项关于自适应闭环算法在最大程度地减少 1 型糖尿病中皮质类固醇引起的应激性高血糖的有效性的对照研究。

• DOI: 10.1177/193229681100500602
• 发表时间: 2011
• 期刊: Journal of diabetes science and technology
• 影响因子: 5
• 作者: ElYoussef,Joseph;Castle,JessicaR;Branigan,DeborahL;Massoud,RyanG;Breen,MatthewE;Jacobs,PeterG;Bequette,BWayne;Ward,WKenneth
• 通讯作者: Ward,WKenneth

Continuous glucose monitoring in subjects with type 1 diabetes: improvement in accuracy by correcting for background current.

• DOI: 10.1089/dia.2010.0020
• 发表时间: 2010-11
• 期刊: Diabetes technology & therapeutics
• 影响因子: 5.4
• 作者: J. El Youssef;J. Castle;J. Engle;Ryan G. Massoud;W. Ward