An Extensible Resource for Genomic Analysis and Petascale Storage

用于基因组分析和千万亿级存储的可扩展资源

• 批准号: 8333728
• 负责人: HAREL WEINSTEIN
• 金额: $ 184.97万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333728
• 关键词: Acquired Immunodeficiency Syndrome; Advisory Committees; Biomedical Research; Cardiovascular Diseases; Center for Translational Science Activities; Charge; Clinical Sciences; Collaborations; Colon Carcinoma; Commit; Congenital Abnormality; Core Facility; Cost Sharing; Coupled; Data; Data Analyses; Data Set; Data Storage and Retrieval; Equipment; Extramural Activities; Funding; Genomics; Housing; Immune System Diseases; Individual; Inflammation; Institutes; Institution; Laboratories; Lymphoma; Malignant neoplasm of lung; Malignant neoplasm of prostate; Mental disorders; Minor; Multiple Sclerosis; National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Performance; Research; Research Personnel; Research Project Grants; Resources; Science; Technology; United States National Institutes of Health; cluster computing; computer infrastructure; design; epigenomics; experience; instrument; instrumentation; meetings; member; protocol development; tool

DESCRIPTION (provided by applicant): This application is for the acquisition of an extensible Resource for Genomic Analysis and Petascale Storage (eRGAPS) instrument: a two petabyte data store tightly coupled to a data analysis computing cluster specifically designed to support genomics-related research. The equipment will support a broad and diverse consortium of investigators (COI) whose NIH funded research projects are either entirely dependent on, or would benefit substantially from, its capabilities. The equipment will also make possible data-intensive research within the Clinical and Translational Science Center (CTSC) and the institutions affiliated with it, as well as through two shared core facilities (the Genomics Resources Core and the Epigenomics Core), which collectively serve over 80 PIs (nearly all NIH-funded). The scope, breadth and depth of the science represented by the research of the instrumentation's COI are remarkable: they range from lymphoma, multiple sclerosis, prostate, colon and lung cancers and inflammation, AIDS and immune diseases, to birth defects and neurodegeneration, and to cardiovascular diseases and psychiatric disorders. Thus, the research is supported by several NIH institutes and centers, including NCI, NINDS, NHLBI, NCRR, NICHD, and NIMH as well as the Office of the Director. Recognizing that it is impractical for individual laboratories to manage the equipment necessary for data storage and analysis at the petascale, we propose to meet this need with the dedicated, professionally managed eRGAPS. This instrument will facilitate rapid research protocol development and reanalysis of primary datasets, will promote collaboration among researchers and facilitate extramural sharing of large, high-quality datasets. The instrumentation will be housed, maintained, and managed technically in the Institute for Computational Biomedicine (ICB) that is directed by the PI of this application, and will be integrated into a high-performance research-oriented computational infrastructure. Technical administration and management will be handled by the Technology Management Team (TechMT) of the ICB, currently comprising a highly skilled staff of five experts who develop and maintain advanced computational capabilities. Scientific and operational oversight of the proposed equipment will be the charge of the PI, supported by a Management and Advisory Committee (MAC) that he will chair and comprised of both Major and Minor eRGAPS users, as well as outside-COI member with appropriate experience. The institution has committed significant resources, including cost sharing, to this instrument that wil function as an essential tool for basic and translational biomedical research and information sharing.

描述（由申请人提供）：本申请用于收购可扩展的基因组分析和Petascale存储资源（eRGAPS）仪器：一个与专门设计用于支持基因组学相关研究的数据分析计算集群紧密耦合的两PB数据存储。该设备将支持一个广泛而多样化的研究者联盟（COI），其NIH资助的研究项目要么完全依赖于其能力，要么将从其能力中受益匪浅。该设备还将使临床和转化科学中心（CTSC）及其附属机构内的数据密集型研究成为可能，以及通过两个共享的核心设施（基因组学资源核心和表观基因组学核心），共同为80多个PI（几乎所有NIH资助）提供服务。仪器COI的研究所代表的科学的范围，广度和深度是显着的：它们的范围从淋巴瘤，多发性硬化症，前列腺，结肠和肺癌和炎症，艾滋病和免疫疾病，出生缺陷和神经变性，心血管疾病和精神疾病。因此，这项研究得到了几个NIH研究所和中心的支持，包括NCI，NINDS，NHLBI，NCRR，NICHD和NIMH以及主任办公室。认识到这是不切实际的个别实验室管理所需的设备，数据存储和分析在千万亿次，我们建议，以满足这一需要的专用，专业管理的eRGAPS。这一工具将有助于快速制定研究方案和重新分析主要数据集，将促进研究人员之间的合作，并促进大型高质量数据集的校外共享。仪器将在计算生物医学研究所（ICB）进行技术安置，维护和管理，该研究所由本申请的PI指导，并将集成到高性能研究型计算基础设施中。技术行政和管理将由ICB的技术管理小组（TechMT）负责，该小组目前由五名开发和维护先进计算能力的专家组成。对拟议设备的科学和操作监督将由PI负责，由他主持的管理和咨询委员会（MAC）提供支持，该委员会由主要和次要eRGAPS用户以及具有适当经验的外部COI成员组成。该机构已承诺为该工具提供大量资源，包括费用分摊，该工具将作为基础和转化生物医学研究和信息共享的重要工具。