An Extensible Resource for Genomic Analysis and Petascale Storage

描述（由申请人提供）：此申请用于获取可扩展的基因组分析资源和千兆级存储（eRGAPS）仪器：一个2 pb的数据存储与一个数据分析计算集群紧密耦合，专门设计用于支持基因组学相关研究。该设备将支持广泛和多样化的研究人员联盟（COI），这些研究项目要么完全依赖于NIH资助的研究项目，要么将从其能力中受益匪浅。该设备还将使临床和转化科学中心（CTSC）及其附属机构以及两个共享核心设施（基因组学资源核心和表观基因组学核心）内的数据密集型研究成为可能，这两个核心设施共同服务于80多个pi（几乎都是nih资助的）。仪器COI研究所代表的科学的范围、广度和深度是显著的：它们的范围从淋巴瘤、多发性硬化症、前列腺癌、结肠癌和肺癌以及炎症、艾滋病和免疫疾病，到出生缺陷和神经变性，以及心血管疾病和精神疾病。因此，这项研究得到了几个NIH研究所和中心的支持，包括NCI、NINDS、NHLBI、NCRR、NICHD和NIMH以及主任办公室。认识到单个实验室管理千兆级数据存储和分析所需的设备是不切实际的，我们建议用专用的、专业管理的eRGAPS来满足这一需求。该仪器将促进快速研究方案的制定和对主要数据集的再分析，将促进研究人员之间的合作，并促进大型高质量数据集的校外共享。该仪器将在计算生物医学研究所（ICB）进行安置、维护和技术管理，该研究所由该应用程序的PI指导，并将集成到高性能研究导向的计算基础设施中。技术行政和管理将由ICB的技术管理小组（TechMT）负责，该小组目前由五名技术高超的专家组成，负责开发和维护先进的计算能力。拟议设备的科学和运营监督将由PI负责，由他担任主席的管理和咨询委员会（MAC）提供支持，该委员会由主要和次要eRGAPS用户以及具有适当经验的外部coi成员组成。该机构已承诺为这一文书提供大量资源，包括分担费用，该文书将作为基础和转化生物医学研究和信息共享的重要工具。

DESCRIPTION (provided by applicant): This application is for the acquisition of an extensible Resource for Genomic Analysis and Petascale Storage (eRGAPS) instrument: a two petabyte data store tightly coupled to a data analysis computing cluster specifically designed to support genomics-related research. The equipment will support a broad and diverse consortium of investigators (COI) whose NIH funded research projects are either entirely dependent on, or would benefit substantially from, its capabilities. The equipment will also make possible data-intensive research within the Clinical and Translational Science Center (CTSC) and the institutions affiliated with it, as well as through two shared core facilities (the Genomics Resources Core and the Epigenomics Core), which collectively serve over 80 PIs (nearly all NIH-funded). The scope, breadth and depth of the science represented by the research of the instrumentation's COI are remarkable: they range from lymphoma, multiple sclerosis, prostate, colon and lung cancers and inflammation, AIDS and immune diseases, to birth defects and neurodegeneration, and to cardiovascular diseases and psychiatric disorders. Thus, the research is supported by several NIH institutes and centers, including NCI, NINDS, NHLBI, NCRR, NICHD, and NIMH as well as the Office of the Director. Recognizing that it is impractical for individual laboratories to manage the equipment necessary for data storage and analysis at the petascale, we propose to meet this need with the dedicated, professionally managed eRGAPS. This instrument will facilitate rapid research protocol development and reanalysis of primary datasets, will promote collaboration among researchers and facilitate extramural sharing of large, high-quality datasets. The instrumentation will be housed, maintained, and managed technically in the Institute for Computational Biomedicine (ICB) that is directed by the PI of this application, and will be integrated into a high-performance research-oriented computational infrastructure. Technical administration and management will be handled by the Technology Management Team (TechMT) of the ICB, currently comprising a highly skilled staff of five experts who develop and maintain advanced computational capabilities. Scientific and operational oversight of the proposed equipment will be the charge of the PI, supported by a Management and Advisory Committee (MAC) that he will chair and comprised of both Major and Minor eRGAPS users, as well as outside-COI member with appropriate experience. The institution has committed significant resources, including cost sharing, to this instrument that wil function as an essential tool for basic and translational biomedical research and information sharing.