Southeastern Sexually Transmitted Infections Cooperative Research Center

东南部性传播感染合作研究中心

• 批准号: 8519209
• 负责人: MARCIA METZGAR HOBBS
• 金额: $ 253.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519209
• 关键词: Adherence; Adjuvant; Animals; Development; Family suidae; Genetic; Gonorrhea; Hemophilus ducreyi; Human; Immune response; Immunization; Immunobiology; Immunologic Monitoring; Immunology; Infection; Iron; Mediator of activation protein; Membrane Proteins; Microbiology; Modeling; Molecular; Mus; Natural Immunity; Neisseria gonorrhoeae; Pathogenesis; Prevention; Protocols documentation; Research; Resistance; Sexually Transmitted Diseases; Specimen; Vaccines; gonorrhea vaccine; mucosal vaccine; novel strategies; pathogen; prevent; research study; vaccine candidate

This is a competing renewal for a Sexually Transmitted Infections Cooperative Research Center (STI ORG). The Southeastern STI ORG is comprised of six projects Including studies on the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi. Five synergistic projects explore molecular pathogenesis, immunobiology and possible vaccines for gonorrhea, and the sixth project focuses on development of a promising vaccine for H. ducreyi. The six projects are supported by an Administrative Core, a Microbiology Core and an Immunology Core. Project 1 uses the murine model of gonococcal infection to study mucosal vaccine candidates. Project 2 focuses on iron-regulated adherence factors of N. gonorrhoeae. Project 3 deals with genetic mechanisms of gonococcal resistance to mediators of innate immunity. Project 4 aims at preventing gonococcal infection by targeting the adherence factor PilG. Project 5 centers on innate host immune responses to gonococcal infection. Project 6 focuses on the H. ducreyi outer membrane protein DsrA as a chancroid vaccine using a swine model of infection. The Microbiology Core will conduct experimental human gonococcal infection experiments in support of Projects 2-5. The Immunology Core provides expertise In mucosal adjuvants and immunization protocols for gonococcal studies in mice and chancroid studies in pigs and sophisticated immune monitoring using specimens from animals and humans. The overall theme uniting these projects and cores is New Approaches to STI Prevention.

这是性传播感染合作研究中心（STI ORG）的竞争性更新。东南STI ORG由六个项目组成，包括对性传播病原体淋病奈瑟菌和杜克雷嗜血杆菌的研究。五个协同项目探索淋病的分子发病机制、免疫生物学和可能的疫苗，第六个项目集中于开发有希望的H. ducreyi。这六个项目由一个行政核心、一个微生物学核心和一个免疫学核心支持。项目1使用淋球菌感染的小鼠模型来研究粘膜疫苗候选物。项目2主要研究铁调节的N.淋病项目3涉及淋球菌对先天免疫介质的抗性的遗传机制。项目4旨在通过靶向粘附因子PilG来预防淋球菌感染。项目5的中心是淋球菌感染的先天宿主免疫反应。项目6的重点是H. ducreyi外膜蛋白DsrA作为软下疳疫苗，使用猪感染模型。微生物学中心将进行人类淋球菌感染实验，以支持项目2-5。免疫学核心为小鼠淋球菌研究和猪软下疳研究提供粘膜佐剂和免疫方案方面的专业知识，并使用动物和人类标本进行复杂的免疫监测。将这些项目和核心项目结合在一起的总主题是预防性传播感染的新方法。