Southeastern Sexually Transmitted Infections Cooperative Research Center

这是性传播感染合作研究中心(STI ORG)的一次竞争性更新。东南部STI ORG由六个项目组成，包括对性传播病原体奈瑟氏菌、淋病奈瑟菌和杜氏嗜血杆菌的研究。五个协同项目探索了淋病的分子发病机制、免疫生物学和可能的疫苗，第六个项目专注于开发一种有前景的杜氏杆菌疫苗。这六个项目由一个行政核心、一个微生物学核心和一个免疫学核心提供支持。项目1使用淋球菌感染的小鼠模型来研究粘膜候选疫苗。项目2重点研究淋病奈瑟菌的铁调节黏附因子。项目3涉及淋球菌对天然免疫介体产生抗药性的遗传机制。项目4旨在通过靶向黏附因子PilG来预防淋球菌感染。项目5的中心是针对淋球菌感染的天然宿主免疫反应。项目6的重点是利用猪感染模型将杜氏嗜血杆菌外膜蛋白DSRA作为软下巴疫苗。微生物学核心将进行实验性的人类淋球菌感染实验，以支持项目2-5。免疫学核心提供在黏膜佐剂和免疫方案方面的专门知识，用于对小鼠的淋病研究和对猪的软骨病研究，以及使用动物和人类的标本进行复杂的免疫监测。联合这些项目和核心的总主题是防止性传播感染的新方法。

This is a competing renewal for a Sexually Transmitted Infections Cooperative Research Center (STI ORG). The Southeastern STI ORG is comprised of six projects Including studies on the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi. Five synergistic projects explore molecular pathogenesis, immunobiology and possible vaccines for gonorrhea, and the sixth project focuses on development of a promising vaccine for H. ducreyi. The six projects are supported by an Administrative Core, a Microbiology Core and an Immunology Core. Project 1 uses the murine model of gonococcal infection to study mucosal vaccine candidates. Project 2 focuses on iron-regulated adherence factors of N. gonorrhoeae. Project 3 deals with genetic mechanisms of gonococcal resistance to mediators of innate immunity. Project 4 aims at preventing gonococcal infection by targeting the adherence factor PilG. Project 5 centers on innate host immune responses to gonococcal infection. Project 6 focuses on the H. ducreyi outer membrane protein DsrA as a chancroid vaccine using a swine model of infection. The Microbiology Core will conduct experimental human gonococcal infection experiments in support of Projects 2-5. The Immunology Core provides expertise In mucosal adjuvants and immunization protocols for gonococcal studies in mice and chancroid studies in pigs and sophisticated immune monitoring using specimens from animals and humans. The overall theme uniting these projects and cores is New Approaches to STI Prevention.