Behavioral and physiological changes in acoustic-electrical pitch matching

声电音调匹配的行为和生理变化

• 批准号: 8263036
• 负责人: Chin-Tuan Tan
• 金额: $ 18.52万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8263036
• 关键词: Acoustics; Address; Adult; Auditory Evoked Potentials; Auditory system; Behavioral; Characteristics; Cochlea; Cochlear Implants; Complex; Contralateral; Data; Dependence; Devices; Diagnostic radiologic examination; Ear; Electric Stimulation; Electrodes; Equation; Face; Frequencies; Future; Goals; Hearing; Image; Implant; Individual; Knowledge; Location; Logic; Maps; Measures; Methods; Nature; Neurons; Patient Care; Patients; Pattern; Performance; Physiological; Pitch Perception; Population; Postoperative Period; Process; Public Health; Recruitment Activity; Relative (related person); Research; Residual state; Shapes; Signal Transduction; Speech; Speech Perception; Techniques; Time; X-Ray Computed Tomography; base; long term memory; novel; public health relevance; relating to nervous system; research study; sound

DESCRIPTION (provided by applicant): One challenge facing a postlingually-deafened adult cochlear implant (CI) user is the possibility that there may be a frequency mismatch between the incoming acoustic signal and the characteristic frequency of the neurons stimulated by the implant. While listeners can clearly adapt to frequency mismatches, there is a lack of information that can allow us to separate the adaptation to frequency mismatches from other distortions that CI users face. In the proposed experiments, we address this issue by examining CI users who have residual hearing in the contralateral ear. Given that frequency mismatches are often heard perceptually as a change in the pitch of the signal relative to the representation stored in long-term memory, we plan to compare the pitch percepts elicited by electrical stimulation with those from the acoustic hearing in the contralateral ear, and observe whether those percepts change over time. Our assumption is that such changes in electrical pitch perception indicate adaptation to a frequency mismatch. By this line of logic, we plan to address the issue of quantifying adaptation to frequency mismatch via three experiments. In the first experiment, we plan to ask CI patients who have sufficient residual hearing in the contralateral ear to match the pitch elicited by stimulation of a given electrode to the pitch elicited by a tone presented to the acoustic-hearing ear. We plan to follow these pitch matches over the first two years of device use, and determine whether changes in pitch perception are also related to changes in speech perception. In the second experiment, we plan to determine the cochlear size and the location of the electrode within the cochlea. From this, we can estimate the amount of frequency mismatch that a given CI user faces. Then, using the data obtained in Experiment 1, we will explore whether larger initial frequency mismatches are associated with larger amounts of adaptation, or with worse overall performance. Finally, in the third experiment, we plan to track electric-acoustic evoked interactions in the P1-N1-P2 complex over the first two years of device use in order to obtain an objective measure of adaptation to frequency mismatch. Taken together, these proposed experiments represent one of the first attempts to quantify the amount of frequency mismatch a given patient has, and the extent to which they are able to adapt to that mismatch. As such, they address a significant lack of knowledge in the cochlear implant field. More importantly, the information gained from these proposed projects has the potential to directly shape future fitting of cochlear implants, and may have an effect on patient care. Here, we propose the use of novel techniques to address this key issue, and as such, we believe that the proposed research has a strong translational component that may ultimately benefit public health for hearing-impaired populations. PUBLIC HEALTH RELEVANCE: Cochlear implants help many people hear, but the signal they provide can be significantly different from that provided by an intact auditory system. Patients who had acoustic hearing, lost it, and then received a cochlear implant, must adapt to the mismatch between the signal provided by the implant and the representations of speech that are stored in their long-term memory. The present study will investigate this adaptation process using behavioral and physiological measures, and this information may assist clinicians in helping patients optimize the benefit they obtain from their device.

描述（由申请人提供）：人工耳蜗（CI）植入后成人用户面临的一个挑战是输入声信号与植入物刺激的神经元特征频率之间可能存在频率失配。虽然听众可以清楚地适应频率失配，但缺乏信息可以使我们将频率失配的适应与CI用户面临的其他失真分开。在拟议的实验中，我们解决这个问题，通过检查CI用户谁在对侧耳有残余听力。考虑到频率不匹配通常被感知为信号音高相对于长期记忆中存储的表征的变化，我们计划将电刺激引起的音高感知与对侧耳的听觉感知进行比较，并观察这些感知是否随时间而变化。我们的假设是，电音高感知的这种变化表明对频率失配的适应。通过这种逻辑，我们计划通过三个实验来解决量化适应频率失配的问题。 在第一个实验中，我们计划要求CI患者在对侧耳中具有足够的剩余听力，以将刺激给定电极引起的音高与呈现给听觉耳朵的音调引起的音高相匹配。我们计划在设备使用的前两年跟踪这些音高匹配，并确定音高感知的变化是否也与语音感知的变化有关。在第二个实验中，我们计划确定耳蜗的大小和电极在耳蜗内的位置。由此，我们可以估计给定CI用户面临的频率失配量。然后，使用实验1中获得的数据，我们将探讨较大的初始频率失配是否与较大的适应量相关，或者与较差的整体性能相关。最后，在第三个实验中，我们计划在设备使用的前两年跟踪P1-N1-P2复合体中的电声诱发相互作用，以获得对频率失配的适应的客观测量。 总的来说，这些拟议的实验代表了量化给定患者频率失配量的首次尝试之一，以及他们能够适应这种失配的程度。因此，它们解决了人工耳蜗领域知识的严重缺乏。更重要的是，从这些拟议项目中获得的信息有可能直接影响未来人工耳蜗的安装，并可能对患者护理产生影响。在这里，我们建议使用新技术来解决这个关键问题，因此，我们相信拟议的研究具有强大的转化成分，最终可能有利于听力受损人群的公共卫生。 公共卫生相关性：耳蜗植入物帮助许多人听到，但它们提供的信号可能与完整的听觉系统提供的信号有很大不同。有听觉的患者，失去了它，然后接受人工耳蜗植入，必须适应植入物提供的信号和存储在他们长期记忆中的语音表示之间的不匹配。本研究将使用行为和生理措施来调查这种适应过程，这些信息可以帮助临床医生帮助患者优化他们从设备中获得的益处。