PHYSIOLOGY AS A POTENTIAL PREDICTOR OF PERCEPTION IN COCHLEAR IMPLANTS

生理学作为人工耳蜗感知的潜在预测因子

• 批准号: 8213442
• 负责人: Michelle L Hughes
• 金额: $ 27.98万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-06 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213442
• 关键词: Accounting; Acoustic Nerve; Affect; Behavioral; Child; Cochlear Implants; Disadvantaged; Discrimination; Electrodes; Generations; Goals; Implant; Individual; Judgment; Lead; Location; Measures; Methods; Pattern; Perception; Performance; Peripheral; Physiological; Physiology; Process; Property; Psychophysiology; Recovery; Refractory; Relative (related person); Research; Research Project Grants; Speech; Speech Perception; Stimulus; Testing; Time; Translating; Work; base; computerized data processing; preference; programs; relating to nervous system; response; sound; speech processing; virtual

DESCRIPTION (provided by applicant): The overall goal of this research project is to better understand the relation between physiological measures of temporal and spatial interaction in cochlear implants (CIs) and performance on psychophysical and speech-perception tasks. Speech-processor program parameters such as stimulation rate, number of electrodes, or stimulus timing (i.e., simultaneous or sequential stimulation) can be manipulated to some extent to reduce interaction in either the temporal or spatial domain. However, it is not clear what the relative contributions of temporal and spatial interaction are to speech-perception ability and how these effects vary across individual CI users. It is possible that interaction affects CI recipients in different ways based on differences in peripheral physiology. Further, differences in peripheral physiology may account for differences in performance as a function of programming choices across individual CI recipients. It is anticipated that research findings from this project may translate into objective methods that can be used to choose specific CI speech-processor programming parameters to maximize performance on an individual basis. This research project consists of three specific aims. The first aim is to evaluate the extent to which physiological measures of auditory-nerve temporal response properties relate to psychophysical measures of temporal integration and performance with different rates of stimulation. These studies will evaluate temporal response properties of the auditory nerve, temporal integration ability, and speech-perception performance with different rates of stimulation. We hypothesize that neural measures such as refractory-recovery and stochastic independence will aid in predicting an optimal stimulation rate for individual CI users. The second aim is to examine the extent to which physiological measures of spatial selectivity are related to pitch ranking and electrode discrimination for intermediate (or virtual) channels. These studies will evaluate the relation between physiological measures of spatial selectivity using actual and virtual channels versus pitch ranking and electrode discrimination tasks. We hypothesize that measures of auditory-nerve spatial selectivity will aid in predicting whether intermediate pitches can be perceived for individual CI users. These measures may lead to objective ways to determine whether an individual subject may benefit from a strategy that employs expanded spectral representation through intermediate or virtual channels. The third aim is to examine the relative effects of physiological and psychophysical channel interaction for simultaneous and sequential stimulation. These studies will evaluate the relative contribution of each type of interaction to determine whether the potential benefits of increased stimulation rate outweigh potential disadvantages of electrical field interaction with simultaneous stimulation. We hypothesize that physiological measures may aid in predicting whether better performance is achieved with a fully sequential strategy versus a partially simultaneous strategy. The goal of this research is to find objective ways to choose speech-processor programming parameters for cochlear implant recipients. The benefits are that recipients would be fit with an optimal program from the beginning of implant use. This is especially important for very young congenitally deafened children who cannot actively participate in formal speech-perception testing or sound-quality judgments, which are traditionally used to determine the best program for an individual.

描述（由申请人提供）：本研究项目的总体目标是更好地了解人工耳蜗（CIs）中时空互动的生理测量与心理物理和言语感知任务的表现之间的关系。语音处理器程序参数，如刺激率、电极数量或刺激时间（即同时或顺序刺激）可以在一定程度上进行操纵，以减少在时间或空间领域的相互作用。然而，目前尚不清楚时间和空间交互作用对言语感知能力的相对贡献，以及这些影响在个体CI用户中如何变化。基于周围生理的差异，相互作用可能以不同的方式影响CI受体。此外，外周生理机能的差异可能解释了个体CI接受者在编程选择方面的表现差异。预计该项目的研究成果可能会转化为客观的方法，可用于选择特定的CI语音处理器编程参数，以在个人基础上最大化性能。这个研究项目包括三个具体目标。第一个目的是评估听神经时间反应特性的生理测量与不同刺激率下时间整合和表现的心理物理测量之间的关系。这些研究将评估不同刺激率下听神经的时间反应特性、时间整合能力和言语感知表现。我们假设神经测量，如难恢复和随机独立性，将有助于预测个体CI用户的最佳刺激速率。第二个目的是研究空间选择性的生理测量在多大程度上与中间（或虚拟）通道的音高排序和电极辨别有关。这些研究将评估使用实际和虚拟通道的空间选择性生理测量与音调排序和电极识别任务之间的关系。我们假设，听觉神经空间选择性的测量将有助于预测中间音高是否可以被个体CI用户感知。这些措施可能导致客观的方法来确定个体受试者是否可以从通过中间或虚拟通道采用扩展频谱表示的策略中受益。第三个目的是检查生理和心理物理通道相互作用对同步和顺序刺激的相对影响。这些研究将评估每种相互作用的相对贡献，以确定增加刺激速率的潜在好处是否大于同时刺激的电场相互作用的潜在缺点。我们假设，生理测量可能有助于预测完全顺序策略与部分同步策略是否能获得更好的表现。本研究的目的是寻找客观的方法来选择人工耳蜗受者的语音处理器编程参数。这样做的好处是，从种植体使用的一开始，接受者就可以适应一个最佳的程序。这对非常年幼的先天性耳聋儿童尤其重要，因为他们不能积极参与正式的言语感知测试或音质判断，而传统上，这些测试是用来确定个人的最佳方案的。