PHYSIOLOGY AS A POTENTIAL PREDICTOR OF PERCEPTION IN COCHLEAR IMPLANTS

生理学作为人工耳蜗感知的潜在预测因子

• 批准号: 7850084
• 负责人: Michelle L Hughes
• 金额: $ 14.6万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850084
• 关键词: Accounting; Acoustic Nerve; Affect; Behavioral; Child; Cochlear Implants; Disadvantaged; Discrimination; Electrodes; Generations; Goals; Implant; Individual; Judgment; Lead; Location; Measures; Methods; Pattern; Perception; Performance; Peripheral; Physiological; Physiology; Process; Property; Psychophysiology; Recovery; Refractory; Relative (related person); Research; Research Project Grants; Speech; Speech Perception; Stimulus; Testing; Time; Translating; Work; base; computerized data processing; preference; programs; relating to nervous system; response; sound; speech processing; virtual

DESCRIPTION (provided by applicant): The overall goal of this research project is to better understand the relation between physiological measures of temporal and spatial interaction in cochlear implants (CIs) and performance on psychophysical and speech-perception tasks. Speech-processor program parameters such as stimulation rate, number of electrodes, or stimulus timing (i.e., simultaneous or sequential stimulation) can be manipulated to some extent to reduce interaction in either the temporal or spatial domain. However, it is not clear what the relative contributions of temporal and spatial interaction are to speech-perception ability and how these effects vary across individual CI users. It is possible that interaction affects CI recipients in different ways based on differences in peripheral physiology. Further, differences in peripheral physiology may account for differences in performance as a function of programming choices across individual CI recipients. It is anticipated that research findings from this project may translate into objective methods that can be used to choose specific CI speech-processor programming parameters to maximize performance on an individual basis. This research project consists of three specific aims. The first aim is to evaluate the extent to which physiological measures of auditory-nerve temporal response properties relate to psychophysical measures of temporal integration and performance with different rates of stimulation. These studies will evaluate temporal response properties of the auditory nerve, temporal integration ability, and speech-perception performance with different rates of stimulation. We hypothesize that neural measures such as refractory-recovery and stochastic independence will aid in predicting an optimal stimulation rate for individual CI users. The second aim is to examine the extent to which physiological measures of spatial selectivity are related to pitch ranking and electrode discrimination for intermediate (or virtual) channels. These studies will evaluate the relation between physiological measures of spatial selectivity using actual and virtual channels versus pitch ranking and electrode discrimination tasks. We hypothesize that measures of auditory-nerve spatial selectivity will aid in predicting whether intermediate pitches can be perceived for individual CI users. These measures may lead to objective ways to determine whether an individual subject may benefit from a strategy that employs expanded spectral representation through intermediate or virtual channels. The third aim is to examine the relative effects of physiological and psychophysical channel interaction for simultaneous and sequential stimulation. These studies will evaluate the relative contribution of each type of interaction to determine whether the potential benefits of increased stimulation rate outweigh potential disadvantages of electrical field interaction with simultaneous stimulation. We hypothesize that physiological measures may aid in predicting whether better performance is achieved with a fully sequential strategy versus a partially simultaneous strategy. The goal of this research is to find objective ways to choose speech-processor programming parameters for cochlear implant recipients. The benefits are that recipients would be fit with an optimal program from the beginning of implant use. This is especially important for very young congenitally deafened children who cannot actively participate in formal speech-perception testing or sound-quality judgments, which are traditionally used to determine the best program for an individual.

描述（由申请人提供）：本研究项目的总体目标是更好地了解人工耳蜗（CI）中时间和空间相互作用的生理测量与心理物理和言语感知任务性能之间的关系。语音处理器程序参数，例如刺激速率、电极数量或刺激定时（即，同时或顺序刺激）可以在一定程度上被操纵以减少时间或空间域中的相互作用。然而，目前还不清楚时间和空间的相互作用的相对贡献是言语感知能力，以及这些影响如何在个体CI用户之间变化。这是可能的，相互作用影响CI收件人以不同的方式在外周生理学的基础上的差异。此外，外周生理学的差异可以解释作为跨个体CI接受者的编程选择的函数的性能差异。预计该项目的研究结果可能会转化为客观的方法，可用于选择特定的CI语音处理器编程参数，以最大限度地提高个人的性能。该研究项目包括三个具体目标。第一个目的是评估在何种程度上的生理措施的神经的时间响应特性相关的心理物理措施的时间整合和性能与不同的刺激率。这些研究将评估听觉神经的时间响应特性、时间整合能力以及不同刺激率下的言语感知性能。我们假设，神经措施，如不应期恢复和随机独立性将有助于预测个人CI用户的最佳刺激率。第二个目的是检查在何种程度上的空间选择性的生理措施相关的间距排名和电极歧视的中间（或虚拟）通道。这些研究将评估使用实际和虚拟通道的空间选择性的生理测量与音高排序和电极辨别任务之间的关系。我们假设，测量的视觉神经的空间选择性将有助于预测中间音高是否可以感知个人CI用户。这些措施可能导致客观的方式来确定是否个别受试者可以受益于一个策略，采用扩展的频谱表示通过中间或虚拟通道。第三个目的是检查同步和顺序刺激的生理和心理物理通道相互作用的相对影响。这些研究将评价每种类型相互作用的相对贡献，以确定增加刺激速率的潜在受益是否超过电场与同时刺激相互作用的潜在缺点。我们假设，生理措施可能有助于预测是否更好的性能是实现了一个完全顺序的策略与部分同步的策略。本研究的目的是找到客观的方法来选择人工耳蜗植入者的语音处理器编程参数。其好处是，接受者将适合从植入物使用开始的最佳程序。这对于那些不能积极参与正式的言语感知测试或声音质量判断的非常年轻的先天性发育不良的儿童尤其重要，这些测试或声音质量判断传统上用于确定个人的最佳方案。