Stanford University Center for Reproductive and Stem Cell biology

斯坦福大学生殖和干细胞生物学中心

• 批准号: 8249005
• 负责人: Renee A Reijo Pera
• 金额: $ 169.96万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249005
• 关键词: Address; Adherence; Basic Science; Biological; Biological Models; Cell Cycle; Cell Differentiation process; Cell Maturation; Clinic; Clinical; Databases; Derivation procedure; Development; Drosophila genus; Education and Outreach; Embryo; Foundations; Future; Genes; Genetic; Genetic Models; Germ Cells; Goals; Health; Health Professional; Human; Human Biology; Human Genetics; Infertility; Informatics; Knowledge; Meiosis; Mus; Oocytes; Outreach Research; Pathway interactions; Pilot Projects; Pluripotent Stem Cells; Primordial Follicle; Production; Registries; Reproduction; Research Design; Research Support; Scientist; Study models; System; Translating; Translational Regulation; Translational Research; Translations; Turner' s Syndrome; Universities; Vision; Woman; base; clinical practice; genetic analysis; human embryonic stem cell; innovation; interest; male; men; novel; outreach; reproductive; sperm cell; stem cell biology

DESCRIPTION (provided by applicant): The objective of our Center is to promote scientific excellence in translational science via well-designed studies of human germ cell development, based on a foundation of knowledge in model systems, and culminating with applications that address critical clinical need. To accomplish our objective, we propose three projects, a pilot project, and four cores. We also present several opportunities for a translational pilot project. The projects are: Project I) Germ Cell Differentiation from Human iPSCs and hESCs (Reijo Pera); Project 2) Translational Regulation of Meiotic Cell Cycle Onset and Progression in the Male (Fuller); Project 3) Derivation of Mature Human Oocytes from Primordial Follicles (Hsueh); and Pilot Project) Regulation of Translational Control in the Oocyte to Embryo Transition (Yao). We also present a translational pilot project for future consideration on primary ovarian insufficiency. Supporting the research are four cores: A) Administration; B) Outreach and Education; C) Microanalysis, Sequencing and Informatics; D) Reproductive Database. This application is a culmination of our reorganization and planning over the last several years and presents our vision for Reproductive and Stem Cell Biology based on outstanding basic and translational science. The application is put forth by a collaborative team that shares common interests in terms of genes and germ cell differentiation and maturation, pathways, developmental systems and overall educational, outreach and research goals. Each project consists of a strong basic component; in addition, three of the five projects and pilots have an equally-strong clinical component encompassing genetic analysis of human germ cell development from pluripotent stem cells to probe fundamental aspects and potential therapies, deriving mature oocytes to remedy primary ovarian insufficiency, and establishing the first registry of women with POI. Each project is relevant to the health of infertile women and men and each is informed by the elegant genetic systems of Drosophila and the mouse. The central theme of our Center is novel, forward-looking and built on a firm foundation of scientific and clinical inquiry with an innovative outreach and educational component with hopes of reaching out to other scientists, healthcare professionals.

描述（由申请人提供）：我们中心的目标是通过精心设计的人类生殖细胞发育研究，促进转化科学的科学卓越，基于模型系统的知识基础，并最终应用于解决关键临床需求。为了实现我们的目标，我们提出了三个项目，一个试点项目和四个核心。我们还提出了几个翻译试点项目的机会。这些项目是：项目I）来自人iPSC和hESC的生殖细胞分化（Reijo Pera）;项目2）雄性中减数分裂细胞周期开始和进展的翻译调控（Fuller）;项目3）从原始卵泡衍生成熟人卵母细胞（Hsueh）;和试点项目）卵母细胞向胚胎转化中的翻译控制调控（Yao）。我们还提出了一个翻译试点项目，为未来考虑原发性卵巢功能不全。支持这项研究的有四个核心：A）管理; B）推广和教育; C）微量分析，测序和信息学; D）生殖数据库。这项申请是我们在过去几年中重组和规划的结果，并提出了我们对生殖和干细胞生物学的愿景，基于杰出的基础和转化科学。该应用程序是由一个合作团队提出的，该团队在基因和生殖细胞分化和成熟，途径，发育系统以及整体教育，推广和研究目标方面拥有共同的兴趣。每个项目包括一个强大的基础组成部分;此外，五个项目和试点中的三个具有同样强大的临床组成部分，包括从多能干细胞中对人类生殖细胞发育进行遗传分析，以探索基本方面和潜在的治疗方法，获得成熟的卵母细胞以补救原发性卵巢功能不全，并建立第一个POI女性登记处。每个项目都与不育妇女和男子的健康有关，每个项目都以果蝇和小鼠的优雅遗传系统为基础。我们中心的中心主题是新颖的，前瞻性的，建立在科学和临床调查的坚实基础上，具有创新的推广和教育成分，希望能接触到其他科学家，医疗保健专业人员。