Stanford University Center for Reproductive and Stem Cell biology

斯坦福大学生殖和干细胞生物学中心

• 批准号: 8070899
• 负责人: Renee A Reijo Pera
• 金额: $ 172.21万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8070899
• 关键词: Stanford; University; Center; Reproductive; Stem

DESCRIPTION (provided by applicant): The objective of our Center is to promote scientific excellence in translational science via well-designed studies of human germ cell development, based on a foundation of knowledge in model systems, and culminating with applications that address critical clinical need. To accomplish our objective, we propose three projects, a pilot project, and four cores. We also present several opportunities for a translational pilot project. The projects are: Project I) Germ Cell Differentiation from Human iPSCs and hESCs (Reijo Pera); Project 2) Translational Regulation of Meiotic Cell Cycle Onset and Progression in the Male (Fuller); Project 3) Derivation of Mature Human Oocytes from Primordial Follicles (Hsueh); and Pilot Project) Regulation of Translational Control in the Oocyte to Embryo Transition (Yao). We also present a translational pilot project for future consideration on primary ovarian insufficiency. Supporting the research are four cores: A) Administration; B) Outreach and Education; C) Microanalysis, Sequencing and Informatics; D) Reproductive Database. This application is a culmination of our reorganization and planning over the last several years and presents our vision for Reproductive and Stem Cell Biology based on outstanding basic and translational science. The application is put forth by a collaborative team that shares common interests in terms of genes and germ cell differentiation and maturation, pathways, developmental systems and overall educational, outreach and research goals. Each project consists of a strong basic component; in addition, three of the five projects and pilots have an equally-strong clinical component encompassing genetic analysis of human germ cell development from pluripotent stem cells to probe fundamental aspects and potential therapies, deriving mature oocytes to remedy primary ovarian insufficiency, and establishing the first registry of women with POI. Each project is relevant to the health of infertile women and men and each is informed by the elegant genetic systems of Drosophila and the mouse. The central theme of our Center is novel, forward-looking and built on a firm foundation of scientific and clinical inquiry with an innovative outreach and educational component with hopes of reaching out to other scientists, healthcare professionals.

描述（由申请人提供）：我们中心的目标是基于模型系统的知识基础，通过精心设计的人类生殖细胞发育研究，促进转化科学领域的科学卓越，并最终实现满足关键临床需求的应用。为了实现我们的目标，我们提出了三个项目、一个试点项目和四个核心项目。我们还提供了一些转化试点项目的机会。这些项目是： 项目 I) 人类 iPSC 和 hESC 的生殖细胞分化 (Reijo Pera)；项目 2) 男性减数分裂细胞周期开始和进展的转化调控 (Fuller)；项目3）从原始卵泡中衍生出成熟的人类卵母细胞（Hsueh）；和试点项目）卵母细胞到胚胎转变中翻译控制的调节（Yao）。我们还提出了一个转化试点项目，供未来考虑原发性卵巢功能不全。支持研究的是四个核心：A）管理； B) 外展和教育； C) 微量分析、测序和信息学； D) 生殖数据库。该应用程序是我们过去几年重组和规划的结晶，展示了我们基于杰出的基础和转化科学的生殖和干细胞生物学愿景。该申请由一个协作团队提出，该团队在基因和生殖细胞分化和成熟、途径、发育系统以及总体教育、推广和研究目标方面有着共同的兴趣。每个项目都包含一个强大的基础组件；此外，五个项目和试点项目中的三个具有同样强大的临床成分，包括对多能干细胞的人类生殖细胞发育进行遗传分析，以探讨基本方面和潜在的疗法，衍生成熟卵母细胞以治疗原发性卵巢功能不全，以及建立第一个 POI 妇女登记处。每个项目都与不育女性和男性的健康相关，并且每个项目都受到果蝇和小鼠的优雅遗传系统的影响。我们中心的中心主题新颖、具有前瞻性，建立在科学和临床探究的坚实基础上，具有创新的外展和教育内容，希望能够接触到其他科学家、医疗保健专业人员。