Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling

开发神经内分泌脑、雄激素和成纤维细胞生长因子信号

• 批准号: 8256749
• 负责人: Wilson Chung
• 金额: $ 19.15万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256749
• 关键词: Androgen Receptor; Androgen Response Element; Androgens; Anosmia; Apoptosis; Biological Sciences; Brain; Cell Nucleus; Cell Survival; Cells; Cerebellum; Data; Development; Development Plans; Disease; Embryo; Embryonic Development; Embryonic Nervous System; Environment; Exhibits; FGF8 gene; Fibroblast Growth Factor; Fibroblast Growth Factor 8; Fibroblast Growth Factor Receptors; Funding; Genes; Genetic Transcription; Goals; Growth Factor; Hippocampus (Brain); Hormones; Human; Hypothalamic structure; In Vitro; Instruction; Kallmann Syndrome; Klinefelter' s Syndrome; Knockout Mice; Knowledge; Laboratories; Lateral; Lead; Mediating; Mentors; Molecular; Morphogenesis; Mus; Nasal septum structure; Nervous system structure; Neuroendocrine Cell; Neurons; Neurosecretory Systems; Nose; Olfactory Epithelium; PC3 cell line; Pattern; Peripheral Nervous System; Play; Postdoctoral Fellow; Pregnancy; Promoter Regions; Proteins; Publishing; Receptor Signaling; Regulation; Reproduction; Research; Research Project Grants; Research Technics; Role; Signal Transduction; Steroid Receptors; Structure; Techniques; Testing; Testosterone; Time; Training; Translational Research; Universities; base; career development; design; fitness; gastrulation; genetic regulatory protein; graduate student; human disease; hyposmia; in vivo; insight; mRNA Expression; malformation; malignant breast neoplasm; meetings; nerve stem cell; novel; olfactory bulb; prenatal; preoptic nucleus; professor; programs; protein expression; receptor expression; reproductive; research facility; steroid hormone; vomeronasal organ

PI. Dr. Ctiung is an assistant professor with in depth knowledge about the role of steroid hormones, steroid receptors and growth factors during brain development. His past research was focused on the cellular and molecular mechanisms involved ih the sexual differentiation ofthe brain. His immediate goal is to enact his independent translational research program studying steroid hormone-dependent growth factor expression underlying CNS morphogenesis as outlined in the ROO section of this proposal. These studies are based on the overall hypothesis: Testosterone regulates the development ofthe neuroendocrine brain via the induction of fibroblast growth factor (FGF) 8/FGF receptor signaling. These studies examine how testosterone regulates FGF8/FGF receptor expression in the embryonic brain, and investigate the consequences of FGFS deficiency on neuroendocrine brain morphogenesis and function. Examination of this hypothesis will result in new insights about how the embryonic neuroendocrine brain is organized in a testosterone-dependent fashion. Career development plan. Dr Chung's activities will focus on: 1) acquiring new research techniques associated with this proposal, 2) attend structured forums designed to promote periodic interactions with his collaborators and disseminate his research data at local and national scientific meetings, 3) mentor and train undergraduate, graduate students and postdoctoral fellows in performing independent research projects. Environment. The research environment at Kent State University for these activities is well-suited. The department of Biological Sciences has provided research facilities and guaranteed start-up funding. Furthermore, Dr. Chung is allowed to spend 75% of his time in order to establish his research program.

圆周率。Ctiung博士是一名助理教授，对类固醇激素、类固醇的作用有深入的了解。 大脑发育过程中的受体和生长因子。他过去的研究集中在细胞和 分子机制与大脑的性别分化有关。他的直接目标是制定他的 研究类固醇激素依赖性生长因子表达的独立翻译研究计划 中枢神经系统形态发生的基础，如本提案的Roo部分所概述。这些研究是基于 总体假设：睾酮通过诱导作用调节神经内分泌脑的发育 成纤维细胞生长因子8/成纤维细胞生长因子受体信号转导。这些研究考察了睾丸激素是如何 调节胚胎脑中FGF8/FGF受体的表达，并研究FGFs的影响 神经内分泌脑的形态发生和功能缺陷。对这一假设的检验将导致 关于胚胎神经内分泌脑是如何在睾丸激素依赖的情况下组织的新见解 时尚。 职业发展计划。钟博士的活动将集中在：1)获得新的研究技术 与此计划相关，2)参加旨在促进与其客户定期互动的结构化论坛 合作者并在地方和国家科学会议上传播他的研究数据，3)指导和培训 本科生、研究生和博士后研究员执行独立研究项目。 环境肯特州立大学的研究环境非常适合这些活动。这个 生物科学系提供了研究设施，并保证了启动资金。 此外，钟博士被允许花费75%的时间来建立他的研究计划。