Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling

Pi. Ctiung博士是一位助理教授，对类固醇激素的作用有深入的了解，类固醇 受体和生长因子在大脑发育过程中的作用。他过去的研究主要集中在细胞和 脑性别分化的分子机制。他的近期目标是制定他的 研究类固醇激素依赖性生长因子表达的独立转化研究计划 潜在的CNS形态发生，如本提案的ROO部分所述。这些研究是基于 总体假设：Tehran通过诱导神经内分泌来调节脑的发育， 成纤维细胞生长因子（FGF）8/FGF受体信号转导。这些研究探讨了睾丸激素 调节胚胎脑中FGF 8/FGF受体的表达，并研究FGFS的后果。 神经内分泌脑形态发生和功能缺乏。对这一假设的检验将导致 关于胚胎神经内分泌大脑如何在睾丸激素依赖的 时尚. 职业发展计划。钟博士的活动将集中在：1）获得新的研究技术 与此建议相关，2）参加旨在促进与他的定期互动的结构化论坛 合作者和传播他的研究数据在当地和国家的科学会议，3）导师和培训 本科生，研究生和博士后研究员进行独立的研究项目。 环境肯特州立大学的研究环境非常适合这些活动。的 生物科学系提供了研究设施，并保证了启动资金。 此外，钟博士被允许花75%的时间来建立他的研究计划。

PI. Dr. Ctiung is an assistant professor with in depth knowledge about the role of steroid hormones, steroid receptors and growth factors during brain development. His past research was focused on the cellular and molecular mechanisms involved ih the sexual differentiation ofthe brain. His immediate goal is to enact his independent translational research program studying steroid hormone-dependent growth factor expression underlying CNS morphogenesis as outlined in the ROO section of this proposal. These studies are based on the overall hypothesis: Testosterone regulates the development ofthe neuroendocrine brain via the induction of fibroblast growth factor (FGF) 8/FGF receptor signaling. These studies examine how testosterone regulates FGF8/FGF receptor expression in the embryonic brain, and investigate the consequences of FGFS deficiency on neuroendocrine brain morphogenesis and function. Examination of this hypothesis will result in new insights about how the embryonic neuroendocrine brain is organized in a testosterone-dependent fashion. Career development plan. Dr Chung's activities will focus on: 1) acquiring new research techniques associated with this proposal, 2) attend structured forums designed to promote periodic interactions with his collaborators and disseminate his research data at local and national scientific meetings, 3) mentor and train undergraduate, graduate students and postdoctoral fellows in performing independent research projects. Environment. The research environment at Kent State University for these activities is well-suited. The department of Biological Sciences has provided research facilities and guaranteed start-up funding. Furthermore, Dr. Chung is allowed to spend 75% of his time in order to establish his research program.