Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling

开发神经内分泌脑、雄激素和成纤维细胞生长因子信号

• 批准号: 8447017
• 负责人: Wilson Chung
• 金额: $ 22.9万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8447017
• 关键词: Androgen Receptor; Androgen Response Element; Androgens; Anosmia; Apoptosis; Biological Sciences; Brain; Cell Nucleus; Cell Survival; Cells; Cerebellum; Data; Development; Development Plans; Disease; Embryo; Embryonic Development; Embryonic Nervous System; Environment; Exhibits; FGF8 gene; Fibroblast Growth Factor; Fibroblast Growth Factor 8; Fibroblast Growth Factor Receptors; Funding; Genes; Genetic Transcription; Goals; Growth Factor; Hippocampus (Brain); Hormones; Human; Hypothalamic structure; In Vitro; Instruction; Kallmann Syndrome; Klinefelter' s Syndrome; Knockout Mice; Knowledge; Laboratories; Lateral; Lead; Mediating; Mentors; Molecular; Morphogenesis; Mus; Nasal septum structure; Nervous system structure; Neuroendocrine Cell; Neurons; Neurosecretory Systems; Nose; Olfactory Epithelium; PC3 cell line; Pattern; Peripheral Nervous System; Play; Postdoctoral Fellow; Pregnancy; Promoter Regions; Proteins; Publishing; Receptor Signaling; Regulation; Reproduction; Research; Research Project Grants; Research Technics; Role; Signal Transduction; Steroid Receptors; Structure; Techniques; Testing; Testosterone; Time; Training; Translational Research; Universities; base; career development; design; fitness; gastrulation; genetic regulatory protein; graduate student; human disease; hyposmia; in vivo; insight; mRNA Expression; malformation; malignant breast neoplasm; meetings; nerve stem cell; novel; olfactory bulb; prenatal; preoptic nucleus; professor; programs; protein expression; receptor expression; reproductive; research facility; steroid hormone; vomeronasal organ

PI. Dr. Ctiung is an assistant professor with in depth knowledge about the role of steroid hormones, steroid receptors and growth factors during brain development. His past research was focused on the cellular and molecular mechanisms involved ih the sexual differentiation ofthe brain. His immediate goal is to enact his independent translational research program studying steroid hormone-dependent growth factor expression underlying CNS morphogenesis as outlined in the ROO section of this proposal. These studies are based on the overall hypothesis: Testosterone regulates the development ofthe neuroendocrine brain via the induction of fibroblast growth factor (FGF) 8/FGF receptor signaling. These studies examine how testosterone regulates FGF8/FGF receptor expression in the embryonic brain, and investigate the consequences of FGFS deficiency on neuroendocrine brain morphogenesis and function. Examination of this hypothesis will result in new insights about how the embryonic neuroendocrine brain is organized in a testosterone-dependent fashion. Career development plan. Dr Chung's activities will focus on: 1) acquiring new research techniques associated with this proposal, 2) attend structured forums designed to promote periodic interactions with his collaborators and disseminate his research data at local and national scientific meetings, 3) mentor and train undergraduate, graduate students and postdoctoral fellows in performing independent research projects. Environment. The research environment at Kent State University for these activities is well-suited. The department of Biological Sciences has provided research facilities and guaranteed start-up funding. Furthermore, Dr. Chung is allowed to spend 75% of his time in order to establish his research program.

Pi. Ctiung博士是一位助理教授，对类固醇激素的作用有深入的了解，类固醇 受体和生长因子在大脑发育过程中的作用。他过去的研究主要集中在细胞和 脑性别分化的分子机制。他的近期目标是制定他的 研究类固醇激素依赖性生长因子表达的独立转化研究计划 潜在的CNS形态发生，如本提案的ROO部分所述。这些研究基于 总体假设：Tehran通过诱导神经内分泌来调节脑的发育， 成纤维细胞生长因子（FGF）8/FGF受体信号转导。这些研究探讨了睾丸激素 调节胚胎脑中FGF 8/FGF受体的表达，并研究FGFS的后果。 神经内分泌脑形态发生和功能缺乏。对这一假设的检验将导致 关于胚胎神经内分泌大脑如何在睾丸激素依赖的 时尚. 职业发展计划。钟博士的活动将集中在：1）获得新的研究技术 与此建议相关，2）参加旨在促进与他的定期互动的结构化论坛 合作者和传播他的研究数据在当地和国家的科学会议，3）导师和培训 本科生，研究生和博士后研究员进行独立的研究项目。 环境肯特州立大学的研究环境非常适合这些活动。的 生物科学系提供了研究设施，并保证了启动资金。 此外，钟博士被允许花75%的时间来建立他的研究计划。

项目成果

Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development.

• DOI: 10.3389/fendo.2013.00089
• 发表时间: 2013
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Stevenson EL;Corella KM;Chung WC
• 通讯作者: Chung WC

Fibroblast Growth Factor 8 Expression in GT1-7 GnRH-Secreting Neurons Is Androgen-Independent, but Can Be Upregulated by the Inhibition of DNA Methyltransferases.

• DOI: 10.3389/fcell.2016.00034
• 发表时间: 2016
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Linscott ML;Chung WC
• 通讯作者: Chung WC

Gender differences in neurodevelopment and epigenetics.

• DOI: 10.1007/s00424-013-1258-4
• 发表时间: 2013-05
• 期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
• 影响因子: 4.5
• 作者: Chung, Wilson C. J.;Auger, Anthony P.
• 通讯作者: Auger, Anthony P.

Fibroblast growth factor 8 regulates postnatal development of paraventricular nucleus neuroendocrine cells.

• DOI: 10.1186/s12993-015-0081-9
• 发表时间: 2015-11-04
• 期刊: Behavioral and brain functions : BBF
• 作者: Rodriguez KM;Stevenson EL;Stewart CE;Linscott ML;Chung WC
• 通讯作者: Chung WC

Perinatal midline astrocyte development is impaired in fibroblast growth factor 8 hypomorphic mice.

成纤维细胞生长因子 8 低效型小鼠的围产期中线星形胶质细胞发育受损。

• DOI: 10.1016/j.brainres.2016.06.015
• 发表时间: 2016
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Stewart,CourtneyE;Corella,KristinaM;Samberg,BrittanyD;Jones,PaulaT;Linscott,MeganL;Chung,WilsonCJ
• 通讯作者: Chung,WilsonCJ