Research Career Development in Child Health
儿童健康研究职业发展
基本信息
- 批准号:8197139
- 负责人:
- 金额:$ 21.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-10 至 2013-11-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAsthmaBasic ScienceBioinformaticsBiomedical ResearchBiometryBiotechnologyBlood Coagulation DisordersBone Marrow TransplantationCardiovascular DiseasesCellular biologyChild health careChildhoodChronicClinicalClinical ResearchCommunitiesCystic FibrosisDiabetes MellitusDiseaseEnsureEnvironmentEpidemiologyEvolutionFacultyFutureGenomicsGoalsImmunityImmunobiologyInfectionInflammationK-Series Research Career ProgramsLaboratoriesLeadLung diseasesMalignant NeoplasmsMentorsMentorshipMetabolic syndromeMethodologyMolecular BiologyMutant Strains MiceObesityOralOxidative StressPathogenesisPhasePhysiciansPneumoniaPopulationProcessProteomicsQualifyingRecruitment ActivityResearchResearch PersonnelResearch SupportScientistSepsisTechnologyTimeTrainingTranslatingViralWritingbioimagingcancer cellcareercareer developmentexperiencein vivointerestmembermetabolomicsnovelpathogenpediatric departmentpediatricianprematureprogramsstem cell biology
项目摘要
The objectives of our Child Health Research Career Development Award Program are to advance research
in child health and to stimulate novel research initiatives and career development for junior pediatric
investigators interested in diseases of childhood. Our Program supports research career development of
pediatricians who have recently completed subspecialty training and who are pursuing careers in basic,
translational and/or clinical research relevant to child health. It includes didactic and research components
to provide training in the pathogenesis and evolution of numerous childhood diseases, including lung disease
associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone
marrow transplantation, diabetes, obesity and cardiovascular disease, diseases caused by viral and bacterial
pathogens, and other illnesses that afflict the pediatric population. The processes underlying these diseases
include acute and chronic inflammation, innate and specific immunity, cancer cell biology, stem cell biology,
and oxidative stress. The technologies and methodologies to address these questions include genomics,
proteomics, metabolomics, bioimaging, cell and molecular biology, bioinformatics, in vivo approaches
including mutant mouse technologies, and epidemiology. A didactic phase includes training in graduate-
level courses in immunobiology, epidemiology and biostatistics and other topics relevant to a scholar's
interests, training in biotechnologies including genomics and proteomics, bioimaging, scientific writing and
oral presentation. A critical component is the mentored research experience in the laboratories of mentors
and co-mentors. The scholars will participate as full members of their selected research program, interacting
with the other members of the program and with co-mentors as required for their projects. Over time, their
own research programs and directions will grow from this nurturing environment. The 44 faculty mentors, 27
from 10 divisions within the Department of Pediatrics, lead outstanding, nationally recognized research
programs, and they interact with many colleagues in the rich communities in cancer, immunobiology,
infection, and metabolic syndrome at CWRU. The goals are 1) to provide outstanding training in
collaborative multi-disciplinary research to prepare our Scholars for successful careers as independent
investigators pursuing important questions in childhood diseases, 2) to develop new investigators with the
necessary competencies and breadth of expertise needed for the future of biomedical research, 3) to provide
excellent mentor- and co-mentorship, 4) to recruit and retain our well-trained new investigators in the
scientific workforce and to ensure adequate representation of diversity among people in that workforce, and
5) to provide a continuing flow of qualified physician scientists well able to pursue basic research
investigating disease processes and to translate findings freely between the basic and clinical spheres.
我们的儿童健康研究职业发展奖励计划的目标是推进研究
儿童健康,并刺激初级儿科的新颖研究举措和职业发展
对儿童疾病感兴趣的研究人员。我们的计划支持研究职业发展
最近完成专科培训并正在从事基础、
与儿童健康相关的转化和/或临床研究。它包括教学和研究部分
提供有关多种儿童疾病(包括肺部疾病)的发病机制和演变的培训
与早产、囊性纤维化、哮喘、肺炎、败血症、癌症、凝血障碍、骨骼相关
骨髓移植、糖尿病、肥胖症和心血管疾病、病毒和细菌引起的疾病
病原体和其他困扰儿科人群的疾病。这些疾病的潜在过程
包括急性和慢性炎症、先天性和特异性免疫、癌细胞生物学、干细胞生物学、
和氧化应激。解决这些问题的技术和方法包括基因组学、
蛋白质组学、代谢组学、生物成像、细胞和分子生物学、生物信息学、体内方法
包括突变小鼠技术和流行病学。教学阶段包括研究生培训
免疫生物学、流行病学和生物统计学以及与学者相关的其他主题的水平课程
兴趣、生物技术培训,包括基因组学和蛋白质组学、生物成像、科学写作和
口头陈述。一个关键组成部分是导师实验室的指导研究经验
和共同导师。学者们将作为其所选研究项目的正式成员参与,并进行互动
与该计划的其他成员以及根据其项目需要的共同导师。随着时间的推移,他们的
自己的研究项目和方向将从这个培育环境中成长。 44位导师,27位
来自儿科 10 个部门,领导杰出的、国家认可的研究
他们与癌症、免疫生物学、
CWRU 的感染和代谢综合征。目标是 1) 提供出色的培训
跨学科合作研究,帮助我们的学者为独立事业的成功做好准备
追寻儿童疾病重要问题的研究人员,2) 培养新的研究人员
未来生物医学研究所需的必要能力和专业知识广度,3)提供
优秀的指导和共同指导,4)招募和留住我们训练有素的新调查员
科学劳动力并确保该劳动力中人员多样性的充分代表性,以及
5)提供源源不断的合格医师科学家,能够很好地从事基础研究
研究疾病过程并在基础和临床领域之间自由地转化研究结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL W. KONSTAN其他文献
MICHAEL W. KONSTAN的其他文献
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{{ truncateString('MICHAEL W. KONSTAN', 18)}}的其他基金
Clinical and Translational Science Collaborative of Cleveland
克利夫兰临床与转化科学合作组织
- 批准号:
9978966 - 财政年份:2018
- 资助金额:
$ 21.49万 - 项目类别:
Clinical and Translational Science Collaborative of Cleveland
克利夫兰临床与转化科学合作组织
- 批准号:
9093875 - 财政年份:2007
- 资助金额:
$ 21.49万 - 项目类别:
Clinical and Translational Science Collaborative of Cleveland
克利夫兰临床与转化科学合作组织
- 批准号:
9093876 - 财政年份:2007
- 资助金额:
$ 21.49万 - 项目类别:
PTC124 AS AN ORAL TREATMENT FOR NONSENSE-MUTATION-MEDIATED CYSTIC FIBROSIS
PTC124 作为无义突变介导的囊性纤维化的口服治疗药物
- 批准号:
7378077 - 财政年份:2006
- 资助金额:
$ 21.49万 - 项目类别:
BIIL284BS IN ADULT AND PEDIATRIC CYSTIC FIBROSIS PATIENTS
BIIL284BS 在成人和儿童囊性纤维化患者中的应用
- 批准号:
7202776 - 财政年份:2005
- 资助金额:
$ 21.49万 - 项目类别:
ORAL THERACLEC-TOTAL IN CF PATIENTS WITH EXOCRINE PANCREATIC INSUFFICIENCY
胰腺外分泌功能不全的 CF 患者口服 THERACLEC-TOTAL
- 批准号:
7202793 - 财政年份:2005
- 资助金额:
$ 21.49万 - 项目类别:
TOBRAMYCIN FOR INHALATION (TOBI) IN YOUNG CHILDREN WITH CYSTIC FIBROSIS
患有囊性纤维化的幼儿吸入用妥布霉素 (Tobi)
- 批准号:
7202765 - 财政年份:2005
- 资助金额:
$ 21.49万 - 项目类别:
BIIL284BS in adult and pediatric cystic fibrosis patients
成人和儿童囊性纤维化患者中的 BIIL284BS
- 批准号:
6974994 - 财政年份:2004
- 资助金额:
$ 21.49万 - 项目类别:
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