Clinical and Translational Science Collaborative of Cleveland

克利夫兰临床与转化科学合作(CTSC)是以下合作项目之一 五家克利夫兰医疗机构-凯斯西储大学、克利夫兰诊所、大学 医院、MetroHealth医疗中心、退伍军人管理局医疗中心以及 社区合作伙伴。CTSC实现了联合成为一个协作的、开发的信息学工具的先前目标， 资源共享，机构承诺，加强协作。巩固和催化 在上一个赠款期间开始的活动将继续进行。此外，CTSC将继续进行严格的评估 它的运营和朝着更大目标的进展。CTSC为下一笔赠款设定了三个新目标 句号。1)加强对翻译1的研究。支持身份识别和结构设计的基础设施 将实施治疗目标的确定以及高通量筛选。支持 将精简以患者为基础的研究的辅助系统招募和测试，并 得到了加强。至关重要的是，CTSC将创建支持系统来指导潜在人类的发展 治疗和诊断从发现到在人类身上使用，2)CTSC将改善 克利夫兰，美国最贫穷和最不健康的城市之一。社区研究伙伴关系的核心是 通过社区焦点小组询问社区，以确定他们的健康优先事项。至少以下一项 这些优先事项，以及根据我们反恐委员会调查界的优势选定的其他优先事项，将是 特别努力的目标。一个基于实践的研究网络已经成功地降低了HgbAlc 在克利夫兰的27,000名糖尿病患者中，三年内增加了一个百分点，这提高了人们对该项目的乐观情绪 确实可以移动针头。3)CTSC与国家CTSA社区的互动将会增加。这个 CTSC最初的重点是向内，在我们本国的机构中建立联系并催化变革， 但在下一个赠款期间，CTSC将增加财团周围的互动。主要关注点是 成为目前正在合作的三个俄亥俄州CTSA(CTSC、哥伦布、辛辛那提)的俄亥俄州联盟 围绕儿童健康和癌症项目，以及NetWellness网站，该网站已扩展 从简单地提供公正的医疗信息到包括临床研究的描述和访问 临床试验。在下一个赠款期间，目标将包括扩展CTSC IRB电子枢纽，以促进 审查以包括其他CTSA站点，增加项目协作，并连接患者数据库 Via Explorys，一个利用电子健康记录的基于网络的信息学工具。 相关性(请参阅说明)： CTSC与人类健康高度相关。以克利夫兰生物医学社区为原型， 我们将开发和测试电子和其他策略，以协调不同的研究功能 机构，如IRB的批准和便捷的数据共享。将克利夫兰社区作为实验室 和我们以实践为基础的研究网络和社区伙伴关系资源为工具，我们将寻求 改善克利夫兰的健康参数。我们还将为翻译1开发更便捷的方法。

The Clinical and Translational Science Collaborative (CTSC) of Cleveland is a collaborative venture among five Cleveland health institutions - Case Western Reserve University, the Cleveland Clinic, University Hospitals, MetroHealth Medical Center, and the Veterans Administration Medical Center, as well as community partners. CTSC achieved prior goals of uniting as a collaborative, developed informatics tools, resource sharing, and institutional commitments to enhance the collaborative. Consolidation and catalytic activities begun in the last grant period will be continued. Moreover, CTSC will continue rigorous evaluation of both its operations and progress toward larger goals. CTSC has set three new goals for the next grant period. 1) Translation 1 research will be enhanced. Infrastructure in support of identification and structural determination of therapeutic targets, as well as high through put screening will be implemented. Support systems to assist in patient based research both recruitment and testing will be streamlined and strengthened. Critically, CTSC will create support systems to guide development of potential human therapeutics and diagnostics from discovery to use in man, 2) CTSC will improve health parameters in Cleveland, one of America's poorest and least healthy cities. Community Research Partnership Core is querying the community via neighborhood focus groups to determine their health priorities. At least one of these priorities, and others selected based on the strengths of our CTSC investigative community, will be targeted for special effort. One practice based research network has already succeeded in reducing HgbAlc in 27,000 diabetics in Cleveland by one percentage point in three years, raising optimism that this project can indeed move the needle. 3) CTSC interactions with the national CTSA community will increase. The initial focus of CTSC was inward, establishing connections and catalyzing change in our home institutions, but in the next grant period the CTSC will increase interactions around the consortium. A primary focus will be the Ohio Consortium ofthe three Ohio CTSAs (CTSC, Columbus, Cincinnati), which currently collaborate surrounding child health and cancer projects, and on the web site NetWellness, which has been expanded from simply providing unbiased medical information to include descriptions of clinical research and access to clinical trials. In the next grant period goals will include extending the CTSC IRB electronic hub for facilitated review to include the other CTSA sites, increasing project collaboration, and connecting patient databases via Explorys, a web based informatics tool utilizing the electronic health record. RELEVANCE (See instructions): The CTSC is highly relevant to human health. Using the Cleveland biomedical community as a prototype, we will develop and test electronic and other strategies for coordinating research functions among different institutions, such as IRB approval and facile data sharing. Using the Cleveland community as a laboratory and our practice based research networks and community partnership resource as tools, we will seek to improve health parameters in Cleveland. We will also develop more facile means for Translation 1.