Clinical and Translational Science Collaborative of Cleveland

克利夫兰的临床和转化科学合作（CTSC）是一个合作企业， 克利夫兰的五个医疗机构-凯斯西储大学，克利夫兰诊所，大学 医院，MetroHealth医疗中心和退伍军人管理局医疗中心，以及 社区合作伙伴。CTSC实现了作为一个协作的、开发的信息学工具联合起来的先前目标， 资源共享和加强合作的机构承诺。巩固和促进 上一个赠款期开始的活动将继续进行。此外，CTSC将继续严格评估 它的运作和朝着更大目标的进展。CTSC为下一笔赠款设定了三个新目标 期1)翻译1研究将得到加强。支持识别和结构化的基础设施 确定治疗靶点，并进行高通量筛选。支持 将简化以患者为基础的研究招募和测试系统， 增强广大至关重要的是，CTSC将建立支持系统，以指导潜在的人类发展。 从发现到用于人类的治疗和诊断，2）CTSC将改善人类的健康参数， 克利夫兰，美国最贫穷和最不健康的城市之一。社区研究伙伴关系核心是 通过邻里焦点小组询问社区，以确定他们的健康优先事项。中的至少一 这些优先事项，以及根据我们反恐安全委员会调查界的优势选定的其他优先事项，将 特别努力的目标。一个基于实践的研究网络已经成功地减少了HgbAlc 在克利夫兰的27,000名糖尿病患者中，三年内增加了一个百分点，这让人乐观地认为， 真的可以移动指针。3)CTSC与国家CTSA社区的互动将增加。的 CTSC最初的重点是向内，建立联系，促进我们国内机构的变革， 但在下一个资助期内，CTSC将增加与财团的互动。主要重点将 作为三个俄亥俄州CTSA（CTSC、哥伦布、辛辛那提）的俄亥俄州联合体，它们目前正在合作 围绕儿童健康和癌症项目，并在网站NetWellness上， 从简单地提供公正的医疗信息，包括临床研究的描述和访问， 临床试验在下一个资助期内，目标将包括扩展CTSC IRB电子中心， 审查以纳入其他CTSA研究中心，增加项目合作，并连接患者数据库 通过Explorys，一种利用电子健康记录的基于网络的信息学工具。 相关性（参见说明）： CTSC与人类健康高度相关。以克利夫兰生物医学社区为原型， 我们将开发和测试电子和其他战略，以协调不同部门之间的研究职能。 机构，如IRB批准和方便的数据共享。把克利夫兰社区当作实验室 和我们的实践为基础的研究网络和社区伙伴关系资源作为工具，我们将寻求 改善克利夫兰的健康状况我们还将为翻译1开发更简便的方法。

The Clinical and Translational Science Collaborative (CTSC) of Cleveland is a collaborative venture among five Cleveland health institutions - Case Western Reserve University, the Cleveland Clinic, University Hospitals, MetroHealth Medical Center, and the Veterans Administration Medical Center, as well as community partners. CTSC achieved prior goals of uniting as a collaborative, developed informatics tools, resource sharing, and institutional commitments to enhance the collaborative. Consolidation and catalytic activities begun in the last grant period will be continued. Moreover, CTSC will continue rigorous evaluation of both its operations and progress toward larger goals. CTSC has set three new goals for the next grant period. 1) Translation 1 research will be enhanced. Infrastructure in support of identification and structural determination of therapeutic targets, as well as high through put screening will be implemented. Support systems to assist in patient based research both recruitment and testing will be streamlined and strengthened. Critically, CTSC will create support systems to guide development of potential human therapeutics and diagnostics from discovery to use in man, 2) CTSC will improve health parameters in Cleveland, one of America's poorest and least healthy cities. Community Research Partnership Core is querying the community via neighborhood focus groups to determine their health priorities. At least one of these priorities, and others selected based on the strengths of our CTSC investigative community, will be targeted for special effort. One practice based research network has already succeeded in reducing HgbAlc in 27,000 diabetics in Cleveland by one percentage point in three years, raising optimism that this project can indeed move the needle. 3) CTSC interactions with the national CTSA community will increase. The initial focus of CTSC was inward, establishing connections and catalyzing change in our home institutions, but in the next grant period the CTSC will increase interactions around the consortium. A primary focus will be the Ohio Consortium ofthe three Ohio CTSAs (CTSC, Columbus, Cincinnati), which currently collaborate surrounding child health and cancer projects, and on the web site NetWellness, which has been expanded from simply providing unbiased medical information to include descriptions of clinical research and access to clinical trials. In the next grant period goals will include extending the CTSC IRB electronic hub for facilitated review to include the other CTSA sites, increasing project collaboration, and connecting patient databases via Explorys, a web based informatics tool utilizing the electronic health record. RELEVANCE (See instructions): The CTSC is highly relevant to human health. Using the Cleveland biomedical community as a prototype, we will develop and test electronic and other strategies for coordinating research functions among different institutions, such as IRB approval and facile data sharing. Using the Cleveland community as a laboratory and our practice based research networks and community partnership resource as tools, we will seek to improve health parameters in Cleveland. We will also develop more facile means for Translation 1.