Clinical and Translational Science Collaborative of Cleveland

克利夫兰临床与转化科学合作组织

• 批准号: 9978966
• 负责人: MICHAEL W. KONSTAN
• 金额: $ 672.2万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9978966
• 关键词: Alzheimer' s Disease; Basic Science; Biotechnology; Cities; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Common Cold; Communities; Country; Disadvantaged; Ensure; Environment; Faculty; Foundations; Funding; Genetic Diseases; Goals; Government Agencies; Grant; Health; Health Benefit; Health system; Healthcare; Hospitals; Human; Incubated; Individual; Infant Mortality; Informatics; Institution; Knowledge; Laboratories; Leadership; Life Expectancy; Location; Longevity; Malignant Neoplasms; Medical center; Methods; Modeling; Movement; National Research Service Awards; Neighborhoods; Neurodegenerative Disorders; Patients; Personal Satisfaction; Population; Positioning Attribute; Preparation; Process; Program Development; Recommendation; Research; Research Methodology; Research Support; Research Training; Resources; Science; Site; Solid; System; TNFSF15 gene; Testing; Time; Training; Training Support; Translational Research; Translations; Underserved Population; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; University Hospitals; Vision; base; career development; catalyst; clinical research site; collaborative environment; design; flexibility; health disparity; improved; inner city; innovation; member; multi-site trial; named group; next generation; novel therapeutics; operation; programs; prototype; research clinical testing; research facility; statistics; suburb; success; translational scientist

Clinical and translational (C/T) research is essential to bring the discoveries of biomedical science to benefit the health and well-being of our nation. The Clinical and Translational Science Collaborative (CTSC) of Cleveland, a collaborative among Case Western Reserve University (CWRU) and its affiliated hospital systems, the Cleveland Clinic (CC), MetroHealth (MH), University Hospitals (UH), and the Louis Stokes Veterans Administration Medical Center (VA), aspires to be a catalyst for high quality C/T research both locally and nationally. The CTSC operates as a fully integrated cooperative, collaborative, and confluent research environment that supports all aspects of clinical and translational science, enabling full access by university faculty at all partner institutions to all CTSC-associated potential collaborators and research resources. It has positioned itself to assume leadership in disseminating best practices and promoting multi-site clinical research. It now seeks funding to support the development of program support required to advance the goals set forth by the 2013 recommendations for the CTSA Program by the IOM (now NAM). The CTSC of Cleveland has created a solid foundation on which to build from, to utilize the power of this collaborative to ensure rigorous and innovative training of the C/T/ workforce, to accelerate the translation of discoveries to patients, to improve the health of Cleveland, and to provide scalable models for other locations throughout the nation. To realize its vision, the CTSC of Cleveland proposes to engage all C/T science stakeholders, the workforce, patients and community members to collaborate locally, regionally, and nationally, to 1) advance human health, 2) develop and cultivate the current and next generation C/T research workforce, with special focus on preparation for team science and increasing the diversity of the workforce, 3) promote integration of our translational processes from discovery through clinical trials, of our community throughout the research enterprise, and of special and underserved populations into C/T research across the lifespan, 4) increase the quality and efficiency of C/T research, particularly multi-site trials, through innovative methods and processes and strong collaboration among CTSC Hubs, and 5) provide innovative informatics to support the training and research environment both within the CTSC and nationally. The CTSC has designed an Administrative Core, six C/T research components: Informatics, Community and Collaboration, Translational Endeavors, Research Methods, Hub Research Capacity, and Network Capacity; and two formal C/T training cores: Institutional Career Development Core (KL2), and the NRSA Training Core (TL1) to accomplish its goals. Commitment to collaboration and innovation in C/T research remain top priorities as the CTSC implements its aims and builds the new iteration of the Clinical and Translational Science Collaborative of Cleveland.

临床和转化（C/T）研究是必不可少的，使生物医学科学的发现，以造福于 我们国家的健康和福祉。克利夫兰的临床和转化科学合作组织（CTSC）， 凯斯西储大学（CWRU）及其附属医院系统之间的合作， 克利夫兰诊所（CC），大都会健康（MH），大学医院（UH）和路易斯斯托克斯退伍军人 管理医学中心（VA），渴望成为本地和本地高质量C/T研究的催化剂， 全国范围内。CTSC作为一个完全集成的合作，协作和融合的研究 支持临床和转化科学的各个方面的环境，使大学能够完全访问 教师在所有合作机构的所有CTSC相关的潜在合作者和研究资源。它有 在传播最佳实践和促进多中心临床研究方面发挥领导作用。 它现在寻求资金，以支持发展所需的方案支助，以推进 2013年，IOM（现在的NAM）对CTSA计划提出了建议。克利夫兰的CTSC创建了 一个坚实的基础上建立，利用这种合作的力量，以确保严格和 C/T/劳动力的创新培训，以加速将发现转化为患者，以改善 克利夫兰的健康，并为全国其他地区提供可扩展的模型。实现其 克利夫兰的CTSC建议让所有C/T科学利益相关者、劳动力、患者和 社区成员在地方、区域和国家各级开展合作，以1）促进人类健康，2）发展 培养当前和下一代C/T研究队伍，特别注重团队准备 科学和增加劳动力的多样性，3）促进我们的翻译过程的整合， 通过临床试验发现，我们的社区在整个研究企业，和特殊的， 在整个生命周期中，将服务不足的人群纳入C/T研究，4）提高C/T的质量和效率 研究，特别是多地点试验，通过创新的方法和流程以及 CTSC中心，以及5）提供创新的信息学，以支持培训和研究环境， CTSC和国家。CTSC设计了一个行政核心，包括六个C/T研究部分： 信息学，社区与协作，翻译努力，研究方法，枢纽研究 能力和网络能力;以及两个正式的C/T培训核心：机构职业发展核心 (KL2)和NRSA培训核心（TL 1）来实现其目标。致力于合作和创新 随着CTSC实现其目标并建立新的临床迭代，C/T研究仍然是首要任务。 和克利夫兰的转化科学合作组织