Pathophysiology and Rehabilitation of Neural Dysfunction

描述（由申请人提供）：本提案为我们的病理生理学和神经功能障碍康复（PRND）培训计划的第五周期寻求资金。该项目由Eric Perreault博士指导，并由dr。CJ Heckman博士和Todd Kuiken医学博士。学员将由23位高度协作的导师指导，涵盖细胞神经生理学、工程学、临床医学等领域，所有这些都强调神经功能障碍的康复。我们项目的具体目标是培养康复科学家，他们了解神经系统残疾患者面临的广泛问题，并拥有临床，科学和定量技能，以减轻这一不断增长的人口的负担。该项目以西北大学为基地，与芝加哥康复研究所密切合作。这两个机构在尖端康复研究方面有着悠久的合作历史，他们的项目对此做出了贡献。在前4个资助周期中，该项目直接资助了34名博士前研究员、24名博士后研究员和5名暑期实习生。这些受训者中有许多现在已成为康复医学领域公认的领军人物。在这次更新申请中，我们寻求在我们过去的成就的基础上，通过创新来增加我们的影响力，这些创新旨在使我们的培训计划的临床部分正规化，增加基础科学家和临床医生之间的沟通和合作，并加强职业发展机会，促进从实习生到独立科学家的过渡。拟培养博士前研究员3人，博士后3人，暑期实习生2人。这比我们目前的水平增加了一名博士后和一名实习生。博士后的增加是为了将我们的培训库扩大到医学博士。这一扩展旨在促进我们的研究项目的翻译部分，并增加所有学员的临床暴露。增加一名暑期实习生是对我们自上次续签以来开发的非常成功的暑期项目的肯定。所有博士预科生都将从生物医学和机械工程系的申请者中选拔，这两个部门的申请者数量丰富且不断增长。博士后也可以通过生理、物理治疗和人体运动科学、物理医学和康复等部门加入我们的项目。后一个部门也将通过现有的临床奖学金计划提供研究物理医生的来源。所有受训者，无论级别如何，都将在我们的项目中完成2年的培训。通过将提出的创新与我们已有的成功实践相结合，我们希望通过培养下一代跨学科领导者，继续推进康复医学的科学和实践。

DESCRIPTION (provided by applicant): This proposal seeks funding for the fifth cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The program is directed by Dr. Eric Perreault, PhD, and co-Directed by Drs. CJ Heckman, PhD and Todd Kuiken, MD, PhD. Trainees will be guided by a total of 23 highly collaborative mentors spanning the range from cellular neurophysiology, to engineering, to clinical medicine, all with an emphasis on rehabilitation from neural dysfunction. The specific objectives of our program are to train rehabilitation scientists who understand the broad spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific and quantitative skils to alleviate the burden on this growing population. The program is based at Northwestern University, in close collaboration with the Rehabilitation Institute of Chicago. These two institutions have a long, collaborative history of cutting-edge rehabilitation research, to which or program has contributed. During our first 4 cycles of funding, the program has directly supported 34 pre- doctoral fellows, 24 postdoctoral fellows, and 5 summer interns. Many of these trainees are now established leaders in the field of rehabilitation medicine. In this renewal application, w seek to build on our past achievements and increase our impact through innovations designed to formalize the clinical component of our training program, increase the communication and collaboration between basic scientists and clinicians, and strengthen the career development opportunities that facilitate the transition from trainee to independent scientist. We propose to train three predoctoral fellows, three postdoctoral fellows and two summer interns. This is an in- crease of one postdoctoral fellow and one intern over our current levels. The postdoctoral increase is dedicated to expanding our training pool to MDs. This expansion is aimed at facilitating the translational component of our research program, and increasing the clinical exposure of all trainees. The increase in one summer intern is in acknowledgment of the highly successful summer program we have developed since our last renewal. All predoctoral trainees will be selected from applicants in the departments of Biomedical and Mechanical Engineering, from which there is an abundant and growing applicant pool. Postdoctoral fellows may also joint our program through the departments of Physiology, Physical Therapy and Human Movement Sciences, and Physical Medicine and Rehabilitation. This latter department also will provide a source of research physiatrists through the existing clinical fellowship program. All trainees, regardless of level, will complete 2 year of training in our program. By integrating the proposed innovations with the successful practices we already have in place, we expect to continue advancing the science and practice of rehabilitation medicine by training the next generation of interdisciplinary leaders. PUBLIC HEALTH RELEVANCE: This proposal seeks funding for the fifth cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The specific objectives are to train rehabilitation scientists who understand the broad spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific and quantitative skills to alleviate the burden on this growing population.