Stretch Reflex Contributions to Multijoint Coordination

牵张反射对多关节协调的贡献

基本信息

项目摘要

DESCRIPTION (provided by applicant): Abnormal interjoint coordination is a hallmark of neuropathologies such as stroke and spinal cord injury, and there is evidence that changes in stretch reflex function may contribute to this discoordination. Understanding the significance of these changes and how they might be reversed or reduced through rehabilitation is best done in the context of the unimpaired state. However, there is little information regarding the role of stretch reflexes in the unimpaired control of multijoint movement and posture. Rather, most human studies have focused on the stretch response to single joint perturbations, which allow for unambiguous regulation of muscle length, but do not address the complexities of real perturbations and real movements involving multiple muscles acting in multiple degrees of freedom. This purpose of this grant is to examine stretch reflex contributions to multijoint coordination in the unimpaired human arm. Specifically we will determine if the muscle activation patterns generated in response to whole limb perturbations arise from neurally-mediated, intermuscular (heteronymous) connections or if they simply represent the autogenic (homonymous) responses of individual muscles linked via the skeleton. In addition, the functional consequences of these actions will be addressed by quantifying the mechanical impact of any observed reflex actions. Our Aims are: 1) To examine the heteronymous reflexes connecting the elbow and shoulder by applying single joint perturbations to a single joint, and recording the changes in muscle activity elicited at both joints. These results will provide a "model-free" assessment of heteronymous linkages. 2) To examine the relative contributions of homonymous and heteronymous stretch reflex pathways in coordinating the response to whole limb perturbations. This will be investigated using a 3DOF robot to perturb limb posture and a 3D biomechanical model to estimate the resulting muscle length changes. Changes in muscle activation that are not directly linked to homonymous length changes are likely to represent the output of heteronymous pathways. 3) To examine the influence of reflexively evoked changes in muscle activity on the regulation of multijoint mechanics. The first two Aims are important for assessing the existence and connectivity of stretch reflex responses, but alone do not establish their functional consequences. The latter requires an assessment of how reflex responses influence the mechanical properties of a limb. This will be accomplished using nonlinear system identification techniques to estimate stretch reflex contributions to multijoint impedance. This study will be the first to investigate the role of multijoint stretch reflexes for coordinating arm posture in the 3DOF relevant to normal function. Our results will provide the essential basis for our further investigations into abnormal reflex function following stroke and will elucidate the degree to which spinal mechanisms should be targeted by rehabilitation interventions.
描述(由申请人提供):关节间协调异常是中风和脊髓损伤等神经病变的标志,有证据表明拉伸反射功能的改变可能导致这种不协调。了解这些变化的重要性,以及如何通过康复来逆转或减少这些变化,最好是在未受损状态的背景下进行。然而,很少有关于拉伸反射在多关节运动和姿势的无损控制中的作用的信息。相反,大多数人类研究都集中在单个关节扰动的拉伸反应上,这允许肌肉长度的明确调节,但没有解决实际扰动的复杂性和涉及多个肌肉在多个自由度下运动的实际运动。这项拨款的目的是研究伸展反射对未受损人类手臂多关节协调的贡献。具体来说,我们将确定整个肢体扰动所产生的肌肉激活模式是由神经介导的肌间(异源)连接引起的,还是仅仅代表通过骨骼连接的单个肌肉的自源(异源)反应。此外,这些动作的功能后果将通过量化任何观察到的反射动作的机械影响来解决。我们的目的是:1)通过对单个关节施加单关节扰动来检查连接肘关节和肩部的异位反射,并记录两个关节引起的肌肉活动的变化。这些结果将为异名联系提供“无模型”评估。2)研究同义和异义牵张反射通路在协调全肢扰动反应中的相对作用。研究人员将使用3D机器人来干扰肢体姿势,并使用3D生物力学模型来估计由此产生的肌肉长度变化。与同义长度变化没有直接联系的肌肉激活变化可能代表异义通路的输出。3)探讨反射性诱发的肌肉活动变化对多关节力学调节的影响。前两个目的对于评估拉伸反射反应的存在和连通性很重要,但单独并不能确定其功能后果。后者需要评估反射反应如何影响肢体的机械性能。这将使用非线性系统识别技术来估计拉伸反射对多关节阻抗的贡献。这项研究将首次探讨多关节拉伸反射在与正常功能相关的三维立体运动中协调手臂姿势的作用。我们的结果将为我们进一步研究中风后的异常反射功能提供必要的基础,并将阐明康复干预应针对脊柱机制的程度。

项目成果

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ERIC JON PERREAULT其他文献

ERIC JON PERREAULT的其他文献

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{{ truncateString('ERIC JON PERREAULT', 18)}}的其他基金

NURTURE: Northwestern University Recruitment to Transform Under-Representation and achieve Equity
培育:西北大学招聘以改变代表性不足并实现公平
  • 批准号:
    10701943
  • 财政年份:
    2022
  • 资助金额:
    $ 22.48万
  • 项目类别:
Noninvasive tools for assessing muscle structure and function
用于评估肌肉结构和功能的无创工具
  • 批准号:
    10539698
  • 财政年份:
    2022
  • 资助金额:
    $ 22.48万
  • 项目类别:
NURTURE: Northwestern University Recruitment to Transform Under-Representation and achieve Equity
培育:西北大学招聘以改变代表性不足并实现公平
  • 批准号:
    10493892
  • 财政年份:
    2022
  • 资助金额:
    $ 22.48万
  • 项目类别:
Noninvasive tools for assessing muscle structure and function
用于评估肌肉结构和功能的无创工具
  • 批准号:
    10696947
  • 财政年份:
    2022
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    8237461
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    8320090
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    8535216
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    8725743
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    7019224
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:
Stretch Reflex Contributions to Multijoint Coordination
牵张反射对多关节协调的贡献
  • 批准号:
    7487843
  • 财政年份:
    2006
  • 资助金额:
    $ 22.48万
  • 项目类别:

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