Zwitterionic Clicking for Enhanced Orthopedics

两性离子点击增强骨科

• 批准号: 8394534
• 负责人: Laurie Lawin
• 金额: $ 18.66万
• 依托单位: INNOVATIVE SURFACE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8394534
• 关键词: Acids; Adhesions; Adsorption; Alkynes; American; Amines; Animal Testing; Azides; Biomimetics; Cell surface; Cells; Chemistry; Contact Lenses; Coronary; Cost Savings; Development; Devices; Erythrocytes; Evaluation; Failure; Friction; Generations; Government; Hand; Health Care Costs; Hip region structure; Implant; Individual; Inflammation; Inflammatory; Japan; Japanese Population; Joint repair; Joints; Knee; Left; Life; Longevity; Marketing; Medical Device; Methodology; Methods; Minor; Modification; Molecular Weight; Motion; Operative Surgical Procedures; Orthopedics; Oxygen; Pain; Particulate; Patients; Persons; Phase; Phospholipids; Phosphorylcholine; Physiological; Polyethylenes; Polymers; Positioning Attribute; Procedures; Process; Property; Proteins; Quality of life; Reaction; Replacement Arthroplasty; Research Personnel; Resistance; Savings; Small Business Innovation Research Grant; Specificity; Stents; Surface; Techniques; Technology; Testing; United States; Water; Work; base; biocompatible polymer; chronic pain; commercialization; copolymer; crosslink; cytokine; design; functional group; hip replacement arthroplasty; implant coating; implant material; improved; in vivo; innovation; knee replacement arthroplasty; macrophage; microbial; monomer; novel; operation; particle; scale up; surface coating

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop new zwitterionic click methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more actives lives, total joint replacement is becoming more common. Current orthopedic joints have average life spans of approximately 20 years. By that point wear on the joint causes particulate formation, with subsequent pain and inflammation, requiring eventual revision. Revision surgeries to replace joint implants are more difficult, painful, and expensive than initial joint replacement. Academic work from Japan demonstrated a promising photochemical graft coating of phosphorylcholine zwitterion that reduced wear significantly while also decreasing pro-inflammatory cytokine release and macrophage recruitment in vivo. However, this method uses hazardous monomer and will not scale well for manufacturing use. This project focuses on "Click To" coating methodology which consists of a pre-made phosphorylcholine or other zwitterionic copolymer that will undergo very fast non-photochemical reactions with the functionalized ultrahigh crosslinked polyethylene orthopedic implant to achieve an implant with increased wear resistance. The "Click To" technology will allow commercialization of the zwitterionic coating technology by a manufacturing-friendly process. PUBLIC HEALTH RELEVANCE: Zwitterionic coatings on orthopedic implants have tremendous potential for decreasing implant wear and improved anti-fouling properties. Approximately 600,000 Americans receive knee and hip implants annually in the US, over 1 million worldwide. This market is large, over $5.4 billion in 2006, and more than a fivefold increase in the number of total joint replacements are expected in the next 20 years. Substantial savings in the United States, on the order of more than $100 million, can be achieved with even a one year improvement of in the average life of an implant. The cost savings is a minor point when the benefit of an improved quality of life for the many users is considered by the elimination of the need for painful revision surgeries.

描述（由申请人提供）：该小型企业创新研究第一阶段项目旨在开发新的两性离子点击方法，用于具有增强耐用性的矫形表面。随着美国人的寿命更长、生活更加活跃，全关节置换术变得越来越普遍。目前的骨科关节平均寿命约为 20 年。到那时，关节磨损会导致颗粒形成，随后出现疼痛和炎症，需要最终修复。更换关节植入物的修复手术比初次关节置换更困难、更痛苦、更昂贵。日本的学术工作证明了一种很有前途的磷酰胆碱两性离子光化学接枝涂层，它可以显着减少磨损，同时还可以减少体内促炎细胞因子的释放和巨噬细胞的募集。然而，这种方法使用危险的单体，并且不能很好地用于制造用途。该项目的重点是“Click To”涂层方法，该方法由预制的磷酸胆碱或其他两性离子共聚物组成，将与功能化超高交联聚乙烯骨科植入物发生非常快速的非光化学反应，以获得具有更高耐磨性的植入物。 “Click To”技术将通过制造友好的工艺实现两性离子涂层技术的商业化。 公共健康相关性：骨科植入物上的两性离子涂层在减少植入物磨损和提高防污性能方面具有巨大潜力。美国每年约有 60 万美国人接受膝关节和髋关节植入术，全球超过 100 万。这个市场很大，2006 年超过 54 亿美元，预计未来 20 年关节置换总数将增加五倍以上。在美国，即使植入物的平均寿命延长一年，也可以节省约 1 亿多美元。当考虑通过消除痛苦的翻修手术来提高许多用户的生活质量的好处时，节省成本只是一个小问题。