Zwitterionic Clicking for Enhanced Orthopedics

描述(由申请人提供)：这个小型企业创新研究第一阶段项目旨在开发用于增强耐用性的整形外科表面的新的两性点击方法。随着美国人寿命的延长和寿命的延长，全关节置换术变得越来越普遍。目前骨科关节的平均寿命约为20年。到那时，关节上的磨损会导致颗粒形成，随后会出现疼痛和炎症，最终需要进行修复。置换关节植入物的翻修手术比最初的关节置换更困难、更痛苦、更昂贵。来自日本的学术研究表明，一种前景看好的磷胆碱两性离子光化学接枝涂层可以显著减少磨损，同时还可以减少体内促炎细胞因子的释放和巨噬细胞的募集。然而，这种方法使用危险的单体，不能很好地扩展到制造用途。该项目的重点是“点击”涂层方法，它由预制的磷酰胆碱或其他两性共聚物组成，它将与功能化的超高交联聚乙烯整形植入物进行非常快速的非光化学反应，以实现具有更高耐磨性的植入物。“点击”技术将允许两性离子涂层技术通过一种有利于制造的工艺实现商业化。 公共卫生相关性：整形外科植入物上的两性离子涂层在减少植入物磨损和改善防污性能方面具有巨大的潜力。在美国，每年约有60万美国人接受膝盖和髋关节植入手术，全球超过100万人。这个市场很大，2006年超过54亿美元，预计在未来20年内关节置换总数将增加五倍以上。在美国，即使只需将植入物的平均寿命延长一年，就可以实现超过1亿美元的大幅节省。当许多使用者的生活质量改善的好处被认为是消除了痛苦的翻修手术的需要时，节省的成本是次要的。

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop new zwitterionic click methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more actives lives, total joint replacement is becoming more common. Current orthopedic joints have average life spans of approximately 20 years. By that point wear on the joint causes particulate formation, with subsequent pain and inflammation, requiring eventual revision. Revision surgeries to replace joint implants are more difficult, painful, and expensive than initial joint replacement. Academic work from Japan demonstrated a promising photochemical graft coating of phosphorylcholine zwitterion that reduced wear significantly while also decreasing pro-inflammatory cytokine release and macrophage recruitment in vivo. However, this method uses hazardous monomer and will not scale well for manufacturing use. This project focuses on "Click To" coating methodology which consists of a pre-made phosphorylcholine or other zwitterionic copolymer that will undergo very fast non-photochemical reactions with the functionalized ultrahigh crosslinked polyethylene orthopedic implant to achieve an implant with increased wear resistance. The "Click To" technology will allow commercialization of the zwitterionic coating technology by a manufacturing-friendly process. PUBLIC HEALTH RELEVANCE: Zwitterionic coatings on orthopedic implants have tremendous potential for decreasing implant wear and improved anti-fouling properties. Approximately 600,000 Americans receive knee and hip implants annually in the US, over 1 million worldwide. This market is large, over $5.4 billion in 2006, and more than a fivefold increase in the number of total joint replacements are expected in the next 20 years. Substantial savings in the United States, on the order of more than $100 million, can be achieved with even a one year improvement of in the average life of an implant. The cost savings is a minor point when the benefit of an improved quality of life for the many users is considered by the elimination of the need for painful revision surgeries.