Zwitterionic Clicking for Enhanced Orthopedics

两性离子点击增强骨科

• 批准号: 8394534
• 负责人: Laurie Lawin
• 金额: $ 18.66万
• 依托单位: INNOVATIVE SURFACE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8394534
• 关键词: Acids; Adhesions; Adsorption; Alkynes; American; Amines; Animal Testing; Azides; Biomimetics; Cell surface; Cells; Chemistry; Contact Lenses; Coronary; Cost Savings; Development; Devices; Erythrocytes; Evaluation; Failure; Friction; Generations; Government; Hand; Health Care Costs; Hip region structure; Implant; Individual; Inflammation; Inflammatory; Japan; Japanese Population; Joint repair; Joints; Knee; Left; Life; Longevity; Marketing; Medical Device; Methodology; Methods; Minor; Modification; Molecular Weight; Motion; Operative Surgical Procedures; Orthopedics; Oxygen; Pain; Particulate; Patients; Persons; Phase; Phospholipids; Phosphorylcholine; Physiological; Polyethylenes; Polymers; Positioning Attribute; Procedures; Process; Property; Proteins; Quality of life; Reaction; Replacement Arthroplasty; Research Personnel; Resistance; Savings; Small Business Innovation Research Grant; Specificity; Stents; Surface; Techniques; Technology; Testing; United States; Water; Work; base; biocompatible polymer; chronic pain; commercialization; copolymer; crosslink; cytokine; design; functional group; hip replacement arthroplasty; implant coating; implant material; improved; in vivo; innovation; knee replacement arthroplasty; macrophage; microbial; monomer; novel; operation; particle; scale up; surface coating

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop new zwitterionic click methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more actives lives, total joint replacement is becoming more common. Current orthopedic joints have average life spans of approximately 20 years. By that point wear on the joint causes particulate formation, with subsequent pain and inflammation, requiring eventual revision. Revision surgeries to replace joint implants are more difficult, painful, and expensive than initial joint replacement. Academic work from Japan demonstrated a promising photochemical graft coating of phosphorylcholine zwitterion that reduced wear significantly while also decreasing pro-inflammatory cytokine release and macrophage recruitment in vivo. However, this method uses hazardous monomer and will not scale well for manufacturing use. This project focuses on "Click To" coating methodology which consists of a pre-made phosphorylcholine or other zwitterionic copolymer that will undergo very fast non-photochemical reactions with the functionalized ultrahigh crosslinked polyethylene orthopedic implant to achieve an implant with increased wear resistance. The "Click To" technology will allow commercialization of the zwitterionic coating technology by a manufacturing-friendly process. PUBLIC HEALTH RELEVANCE: Zwitterionic coatings on orthopedic implants have tremendous potential for decreasing implant wear and improved anti-fouling properties. Approximately 600,000 Americans receive knee and hip implants annually in the US, over 1 million worldwide. This market is large, over $5.4 billion in 2006, and more than a fivefold increase in the number of total joint replacements are expected in the next 20 years. Substantial savings in the United States, on the order of more than $100 million, can be achieved with even a one year improvement of in the average life of an implant. The cost savings is a minor point when the benefit of an improved quality of life for the many users is considered by the elimination of the need for painful revision surgeries.

描述（由申请人提供）：这个小型企业创新研究阶段I项目旨在为具有增强耐用性的骨科表面开发新的zwitterionic点击方法。随着美国人的寿命更长，更多的活跃人士的生活，总的联合替代者变得越来越普遍。当前的骨科关节的平均寿命约为20年。到那时，关节磨损会导致颗粒形成，随后疼痛和炎症，最终需要修订。比初始置换量要替代关节植入物的修订手术更困难，痛苦和昂贵。来自日本的学术工作表明，磷酸里胆碱裂伤的光化学移植物涂层可显着降低磨损，同时还减少了促炎性细胞因子释放和体内巨噬细胞的募集。但是，该方法使用危险的单体，并且不能很好地扩展用于制造使用。该项目着重于“单击”涂层方法，该方法由预制的磷酸胆碱或其他Zwitterionic共聚物组成，该方法将与功能化的超高交联的多乙二基矫形器植入物进行非常快速的非光化学反应，以增加耐磨性的植入物。 “点击”技术将允许通过制造友好的过程将Zwitterionic涂层技术进行商业化。 公共卫生相关性：骨科植入物上的际离子涂层具有降低植入物磨损和改善抗污染特性的巨大潜力。全球大约有60万美国人每年在美国接受膝盖和臀部植入物。这个市场庞大，2006年超过54亿美元，预计未来20年的联合替代者数量将增加五倍以上。以超过1亿美元的订单，在美国的平均寿命一年提高了一年的改善，在美国的大量节省也可以实现。当消除对痛苦的修订手术的需求来考虑许多用户的生活质量改善的生活质量的好处是一个小点。