TRAINING IN MOLECULAR DERMATOLOGY AND CUTANEOUS CONNECTIVE TISSUE DISEASES

描述（由申请人提供）：这是一份新的申请，要求支持NRSA机构研究培训资助（T32），“分子皮肤病学和皮肤结缔组织疾病培训”。该计划的总体目标是为以下人员提供严格的科学培训：(a)积极进取的医生致力于成为下一代皮肤科医师/科学家的成员；(b)致力于进行适用于皮肤病学和结缔组织疾病的基础科学研究的高素质博士；(c)在美国皮肤病委员会指导下寻求临床转化研究培训的皮肤科住院医师。该计划旨在提供(a)密切监督，强化实验室研究培训，强调应用分子生物学，细胞生物学，人类遗传学和生物化学的最先进方法来研究影响皮肤结缔组织的疾病的病因，发病机制和治疗，和/或(b)在美国国立卫生研究院资助的人类临床研究项目（K30）的背景下进行结构化的转化临床研究培训。被录取的成功候选人是根据他们在生物医学研究方面的杰出前景、对皮肤生物学的浓厚兴趣和对学术医学的坚定承诺来选择的。跨学科和跨部门的导师代表了杰斐逊医学院教师的广泛科学专业知识，核心教师来自皮肤病学和皮肤生物学系。该学院长期致力于培养结缔组织研究方面的医生/科学家和博士，并致力于招募代表性不足的少数民族，特别是女性和西班牙裔个人。过去，该计划的教员在培养那些留在生物化学、分子和细胞生物学、分子遗传学等学术领域的个人方面非常成功，因为这些领域与皮肤病学、皮肤生物学和结缔组织疾病有关；一些以前的研究员由教师培训仍然是全职院士，他们中的许多人在皮肤病学和其他临床学科的领导地位。该培训计划将各种培训活动整合为一个统一的计划，将重点放在皮肤疾病和结缔组织疾病的研究上。提供的培训机会有一个统一的目标，准备学员在分子生物学，遗传学，细胞生物学，生物化学和人类临床研究的最先进的方法的应用，以研究影响结缔组织的广谱条件。在课程结束时，学员将准备获得学术任命，并从事医生/科学家、临床调查员或能够在皮肤病学和结缔组织疾病相关领域建立独立研究项目的博士学位。

DESCRIPTION (provided by applicant): This is a new application requesting support for a NRSA Institutional Research Training Grant (T32), "Training in Molecular Dermatology and Cutaneous Connective Tissue Diseases". The general objective of this Program is to provide rigorous scientific training to: (a) highly motivated physicians committed to become members of the next generation of physician/scientists in the context of extended residency training in dermatology; (b) highly qualified Ph.D.s committed to conduct basic science research applicable to dermatology and connective tissue diseases; and (c) dermatology residents who seek training in clinical translational research under the guidelines of the American Board of Dermatology. The program is designed to provide (a) closely supervised, intensive laboratory research training emphasizing the application of state-of-the-art methods of Molecular Biology, Cell Biology, Human Genetics and Biochemistry towards the investigation of the etiology, pathogenesis, and treatment of diseases affecting cutaneous connective tissues, and/or (b) structured translational clinical research training in the context of a NIH-sponsored program in Human Clinical Investigation (K30). The successful candidates admitted to the program are selected on the basis of their exceptional promise in biomedical research, strong interest in cutaneous biology, and the firm commitment to academic medicine. The interdisciplinary and interdepartmental body of mentors represents the broad scientific expertise of the faculty of Jefferson Medical College, the core faculty members being from the Department of Dermatology and Cutaneous Biology. This faculty has long-term commitment and established track record in training physician/scientists and Ph.D.s in connective tissue research, with strong commitment to the recruitment of underrepresented minorities, particularly women and Hispanic individuals. The program faculty has been in the past highly successful in training individuals who have remained in the academic spheres of biochemistry, molecular and cellular biology, and molecular genetics, as they relate to dermatology, cutaneous biology and connective tissue diseases; several previous fellows trained by the faculty have remained as full- time academicians, many of them in leadership positions in dermatology and other clinical disciplines. The training program consolidates various training activities into a unified program which will focus on the study of skin disorders and connective tissue diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of molecular biology, genetics, cell biology, biochemistry, and human clinical investigation to the study of broad spectrum of conditions affecting the connective tissues. At the completion of the program, trainees will be prepared to obtain academic appointments and to pursue careers as physician/scientists, clinical investigators or as Ph.D.s capable of establishing independent research programs in the areas relevant to dermatology and connective tissue diseases.