EB2015: DEBRA International Symposium on Epidermolysis Bullosa

EB2015：DEBRA 大疱性表皮松解症国际研讨会

• 批准号: 8911585
• 负责人: JOUNI UITTO
• 金额: $ 3万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911585
• 关键词: Advocate; Americas; Applications Grants; Area; Basic Science; Biology; Bulla; Cicatrix; Clinical; Clinical Treatment; Clinical Trials; Collaborations; Communities; Consensus; Cutaneous; Dermatology; Diagnostic; Disease; Doctor of Philosophy; Epidemiology; Epidermolysis Bullosa; Europe; Faculty; Family; Fostering; Future; Genes; Genetic; Genomics; Germany; Goals; Incentives; Institutes; International; Latin America; London; Malignant Neoplasms; Minority; Modeling; Molecular; New York; Participant; Pathogenesis; Patient advocacy; Patients; Physicians; Postdoctoral Fellow; Pre-Clinical Model; Principal Investigator; Proteins; Regenerative Medicine; Request for Applications; Research; Research Personnel; Scientific Advances and Accomplishments; Scientist; Series; Skin; Societies; Staging; Students; Syndrome; Technology; Time; Tissue Engineering; Translational Research; Underrepresented Minority; United States; Universities; Update; Work; abstracting; advocacy organizations; base; career development; data exchange; effective therapy; induced pluripotent stem cell; interdisciplinary approach; interest; meetings; member; posters; pre-clinical research; programs; public health relevance; stem cell biology; stem cell technology; symposium; therapy development

 DESCRIPTION (provided by applicant): This grant application requests support for a meeting, "EB2015: DEBRA International Symposium on Epidermolysis Bullosa", to be held on May 3-6, 2015, in Braselton, GA. The conference is part of a series of triennial research meetings on epidermolysis bullosa (EB), a devastating heritable blistering disease for which there is no effective treatment or cure. These meetings are sponsored by DEBRA International, the coalition of global patient advocacy organizations, and the host and the organizer of this meeting will be DEBRA America, a not-for-profit organization advocating on behalf of patients with EB and their families. The overall goal of this symposium is to provide an international forum for the cadre of premiere scientists working in fields relating to skin fragility syndromes i the spectrum of EB. The organizing committee has developed a program, with the specific aims to foster a greater understanding of the clinical problems of EB; present and discuss advances in cutting edge scientific research on EB; promote collaboration between basic scientists and clinicians; and provide opportunities for students, post-doctoral fellows and young investigators in the field with interest in pathogenesis and treatment of cutaneous diseases. The thematic sessions focus on (1) framing the challenges; (2) provide patient perspectives and review the unmet clinical needs; (3) review the basic science advances in genetics, genomics and diagnostics; (4) discuss prospects of genetic and replacement strategies; (5) protein and stem cell biology; (6) induced pluripotent stem cell technologies; (7) tissue engineering and preclinica models; (8) cancer and scarring in EB; (9) update on clinical trials; and (10) looking ahead to commercializing EB therapies. The audience is expected to consist of ~150 participants, including a significant number of young and new investigators in the field - students, fellows, and junior faculty. The organizers will also reach out to communities of under-represented minorities with invitations and incentives to participate in this meeting, towards building a pipeline of future minority researchers in cutaneous biology and particularly EB. We believe that the planned meeting is extremely timely, and it is expected to prove its usefulness in bringing interdisciplinary approaches for the research themes for the future with focus on developing molecular approaches for treatment, and perhaps a cure, for EB and related heritable blistering diseases.

 描述（由申请人提供）：本资助申请要求支持一次会议，“EB 2015：DEBRA关于大疱性表皮病的国际研讨会”，将于2015年5月3日至6日在佐治亚州布拉塞尔顿举行。这次会议是一系列三年一次的大疱性表皮病（EB）研究会议的一部分，EB是一种毁灭性的遗传性起泡疾病，目前尚无有效的治疗方法。这些会议由全球患者倡导组织联盟DEBRA International赞助，本次会议的主办方和组织者将是DEBRA America，这是一个代表EB患者及其家属的非营利组织。本次研讨会的总体目标是为在EB光谱中与皮肤脆性综合征相关领域工作的杰出科学家提供一个国际论坛。组委会制定了一项计划，其具体目标是促进对EB临床问题的更好理解;介绍和讨论EB前沿科学研究的进展;促进基础科学家和临床医生之间的合作;并为学生，博士后研究员和年轻研究人员提供机会。专题会议的重点是：（1）提出挑战;（2）提供病人的观点，并审查未满足的临床需求;（3）审查遗传学、基因组学和诊断学的基础科学进展;（4）讨论遗传和替代战略的前景;（5）蛋白质和干细胞生物学;（6）诱导多能干细胞技术;（7）组织工程和临床前模型;（7）生物医学和生物医学。（8）EB中的癌症和疤痕;（9）临床试验的最新进展;以及（10）展望EB治疗的商业化。观众预计将包括约150名参与者，包括大量的年轻和新的研究人员在该领域的学生，研究员和初级教师。组织者还将接触代表性不足的少数民族社区，邀请和激励他们参加这次会议，以建立未来皮肤生物学，特别是EB少数民族研究人员的管道。我们相信，计划中的会议是非常及时的，预计将证明其在为未来的研究主题带来跨学科方法方面的有用性，重点是开发治疗EB和相关遗传性水疱疾病的分子方法，也许是治愈方法。