Genetic and Trait Influences on Pain Heterogeneity

遗传和性状对疼痛异质性的影响

基本信息

批准号：
8289500
负责人：
Laura A Frey Law
金额：
$ 12.05万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-08 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8289500
关键词：
ADRB2 gene ASIC channel Acute Pain Adrenergic Agents Affect Animals Anxiety Biological Candidate Disease Gene Caring Carpal Tunnel Syndrome Catecholamines Clinical Clinical Research Complex Cutaneous Muscle Decision Making Degenerative polyarthritis Diagnosis Diagnostic Dissociation Emotional Environment Enzymes Evidence based practice Exposure to Female Fibromyalgia Fright Gender Gender Role Genes Genetic Genetic Drift Genotype Goals Healthcare Heterogeneity Hospitals Human Hyperalgesia Individual Individual Differences Inflammation Infusion procedures Injury Intramuscular Investigation Ischemia Joint Commission on Accreditation of Healthcare Organizations Lead Link Low Back Pain Measurable Measures Mechanics Mediating Medical Metabolic Methyltransferase Methyltransferase Gene Modeling Muscle Musculoskeletal Pain Myalgia Neurotic Disorders Nociception Nociceptive Stimulus Nociceptors Opioid Osteoporosis Outcome Pain Pain intensity Pain-Free Pathology Pathway interactions Patient Care Patients Perception Peripheral Personality Personality Traits Phosphate Buffer Play Population Postoperative Pain Predictive Value Process Psychological Factors Quality of life Replacement Arthroplasty Reporting Research Research Training Role Sensory Severities Sex Characteristics Single Nucleotide Polymorphism Societies Source Stimulus Syndrome TRPV1 gene Testing Tissues Training Treatment outcome Variant adrenergic base biopsychosocial chronic pain clinical care clinical decision-making clinically relevant disability emotional experience expectation experience human subject improved insight male medical attention multidisciplinary novel patient population psychologic response sex social somatosensory trait translational study treatment planning treatment strategy vanilloid receptor subtype 1 willingness

项目摘要

DESCRIPTION (provided by applicant): Pain, an unpleasant sensory and emotional experience, is a significant often under-recognized medical problem spanning numerous patient populations. One of the leading causes for individuals to seek medical attention is musculoskeletal pain. Indeed, pain is now considered the 5th vital sign. Unfortunately, pain is highly variable between individuals. In both acute and chronic pain conditions, there is often a dissociation of pain perception and the underlying pathology in a variety of conditions such as low back pain, osteoporosis or osteoarthritis. Significant pain that is disproportionate to the physical findings is challenging to treat and can result in decreased quality of life and greater disability. Thus, pain heterogeneity associated with common clinical conditions Interferes with diagnosis and adequate treatment, ultimately compromising healthcare. The biopsychosocial model of pain suggests pain perception is a complex process that involves a myriad of physical, social, and emotional components. While no one factor can explain pain heterogeneity, individual differences in gender, genotype, and psychological traits may play a significant role. Unfortunately, it is difficult to find individuals with adequate multidisciplinary training to investigate pain from a multi-factorial perspective. Thus, the goal of the proposed research and training is to gain the expertise to determine the degree to which measurable Individual differences, e.g. sex, genotype and personality traits, predict high and low pain responses. This translational study approach utilizes a controlled, deep-tissue, algesic stimulus in human subjects to critically examine factors that contribute to pain heterogeneity. The Intramuscular infusion of an acidic phosphate buffer provides a clinically-relevant nociceptive stimulus of deep-tissue pain. This novel model provides a unique opportunity to study the Influence of baseline individual differences without the confounding factors associated with clinical pain syndromes. RELEVANCE: Musculoskeletal pain is a prevalent problem in our society and pain heterogeneity between individuals may result from multiple factors. This research plan will assess the role of normal personality traits, sex, and genotype on muscle pain sensitivity. This information may improve diagnosis and treatment strategies for musculoskeletal pain, advancing healthcare through increasingly individualized patient care approaches.

描述（由申请人提供）：疼痛，一种令人不愉快的感觉和情感体验，是跨越众多患者人群的重要认可的医学问题。个人寻求医疗护理的主要原因之一是肌肉骨骼疼痛。确实，疼痛现在被认为是第五个生命体征。不幸的是，个体之间的疼痛是高度变化的。在急性和慢性疼痛条件下，在各种疾病中，疼痛感和潜在的病理通常都存在分离，例如下背部疼痛，骨质疏松症或骨关节炎。与物理发现不成比例的巨大疼痛在治疗中具有挑战性，可能导致生活质量下降和更大的残疾。因此，与常见临床状况相关的疼痛异质性会干扰诊断和适当治疗，最终损害医疗保健。疼痛的生物心理社会模型表明疼痛感是一个复杂的过程，涉及无数的身体，社会和情感成分。尽管没有一个因素可以解释疼痛异质性，但性别，基因型和心理特征的个体差异可能起着重要作用。不幸的是，很难找到接受足够多学科培训的人来从多因素的角度研究疼痛。因此，拟议的研究和培训的目标是获得专业知识，以确定可测量的个体差异，例如性别，基因型和人格特征预测疼痛的高和低疼痛反应。这种翻译研究方法利用人类受试者中受控的，深层的，高的，高刺激的刺激来检查导致疼痛异质性的因素。酸性磷酸盐缓冲液的肌内输注提供了与组织疼痛的临床上相关的伤害性刺激。这个新型模型提供了一个独特的机会，可以研究基线个体差异的影响，而没有与临床疼痛综合征相关的混杂因素。相关性：肌肉骨骼疼痛是我们社会中普遍的问题，个体之间的疼痛异质性可能是由多种因素造成的。该研究计划将评估正常人格特征，性别和基因型对肌肉疼痛敏感性的作用。该信息可能会改善肌肉骨骼疼痛的诊断和治疗策略，从而通过日益个性化的患者护理方法来推进医疗保健。