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Genetic and Trait Influences on Pain Heterogeneity

遗传和性状对疼痛异质性的影响

基本信息

批准号：
8289500
负责人：
Laura A Frey Law
金额：
$ 12.05万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-08 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8289500
关键词：
ADRB2 gene ASIC channel Acute Pain Adrenergic Agents Affect Animals Anxiety Biological Candidate Disease Gene Caring Carpal Tunnel Syndrome Catecholamines Clinical Clinical Research Complex Cutaneous Muscle Decision Making Degenerative polyarthritis Diagnosis Diagnostic Dissociation Emotional Environment Enzymes Evidence based practice Exposure to Female Fibromyalgia Fright Gender Gender Role Genes Genetic Genetic Drift Genotype Goals Healthcare Heterogeneity Hospitals Human Hyperalgesia Individual Individual Differences Inflammation Infusion procedures Injury Intramuscular Investigation Ischemia Joint Commission on Accreditation of Healthcare Organizations Lead Link Low Back Pain Measurable Measures Mechanics Mediating Medical Metabolic Methyltransferase Methyltransferase Gene Modeling Muscle Musculoskeletal Pain Myalgia Neurotic Disorders Nociception Nociceptive Stimulus Nociceptors Opioid Osteoporosis Outcome Pain Pain intensity Pain-Free Pathology Pathway interactions Patient Care Patients Perception Peripheral Personality Personality Traits Phosphate Buffer Play Population Postoperative Pain Predictive Value Process Psychological Factors Quality of life Replacement Arthroplasty Reporting Research Research Training Role Sensory Severities Sex Characteristics Single Nucleotide Polymorphism Societies Source Stimulus Syndrome TRPV1 gene Testing Tissues Training Treatment outcome Variant adrenergic base biopsychosocial chronic pain clinical care clinical decision-making clinically relevant disability emotional experience expectation experience human subject improved insight male medical attention multidisciplinary novel patient population psychologic response sex social somatosensory trait translational study treatment planning treatment strategy vanilloid receptor subtype 1 willingness

项目摘要

DESCRIPTION (provided by applicant): Pain, an unpleasant sensory and emotional experience, is a significant often under-recognized medical problem spanning numerous patient populations. One of the leading causes for individuals to seek medical attention is musculoskeletal pain. Indeed, pain is now considered the 5th vital sign. Unfortunately, pain is highly variable between individuals. In both acute and chronic pain conditions, there is often a dissociation of pain perception and the underlying pathology in a variety of conditions such as low back pain, osteoporosis or osteoarthritis. Significant pain that is disproportionate to the physical findings is challenging to treat and can result in decreased quality of life and greater disability. Thus, pain heterogeneity associated with common clinical conditions Interferes with diagnosis and adequate treatment, ultimately compromising healthcare. The biopsychosocial model of pain suggests pain perception is a complex process that involves a myriad of physical, social, and emotional components. While no one factor can explain pain heterogeneity, individual differences in gender, genotype, and psychological traits may play a significant role. Unfortunately, it is difficult to find individuals with adequate multidisciplinary training to investigate pain from a multi-factorial perspective. Thus, the goal of the proposed research and training is to gain the expertise to determine the degree to which measurable Individual differences, e.g. sex, genotype and personality traits, predict high and low pain responses. This translational study approach utilizes a controlled, deep-tissue, algesic stimulus in human subjects to critically examine factors that contribute to pain heterogeneity. The Intramuscular infusion of an acidic phosphate buffer provides a clinically-relevant nociceptive stimulus of deep-tissue pain. This novel model provides a unique opportunity to study the Influence of baseline individual differences without the confounding factors associated with clinical pain syndromes. RELEVANCE: Musculoskeletal pain is a prevalent problem in our society and pain heterogeneity between individuals may result from multiple factors. This research plan will assess the role of normal personality traits, sex, and genotype on muscle pain sensitivity. This information may improve diagnosis and treatment strategies for musculoskeletal pain, advancing healthcare through increasingly individualized patient care approaches.

描述(由申请人提供)：疼痛，一种令人不快的感觉和情感体验，是一个跨越众多患者群体的重要的、往往被低估的医学问题。个人寻求医疗服务的主要原因之一是肌肉骨骼疼痛。事实上，疼痛现在被认为是第五生命体征。不幸的是，疼痛在不同的人之间有很大的差异。在急性和慢性疼痛情况下，在各种情况下，如下腰痛、骨质疏松症或骨关节炎，通常会出现痛觉和潜在病理的分离。严重的疼痛与体检结果不成比例，治疗起来具有挑战性，并可能导致生活质量下降和更大的残疾。因此，与常见临床条件相关的疼痛异质性干扰了诊断和适当的治疗，最终损害了医疗保健。疼痛的生物-心理-社会模型表明，疼痛感知是一个复杂的过程，涉及到无数的身体、社会和情感成分。虽然没有一个因素可以解释疼痛的异质性，但性别、基因和心理特征的个体差异可能起到重要作用。不幸的是，很难找到受过足够多学科训练的人从多因素的角度来研究疼痛。因此，拟议的研究和培训的目标是获得专业知识，以确定可测量的个体差异，如性别、基因和个性特征，预测高和低疼痛反应的程度。这种转化性研究方法利用受试者受控的、深层组织的疼痛刺激，批判性地检查导致疼痛异质性的因素。肌肉内注入酸性磷酸盐缓冲液提供了临床上相关的深部组织疼痛的伤害性刺激。这个新的模型提供了一个独特的机会来研究基线个体差异的影响，而不是与临床疼痛综合征相关的混杂因素。相关性：肌肉骨骼疼痛在我们的社会中是一个普遍存在的问题，个体之间的疼痛异质性可能是多种因素造成的。这项研究计划将评估正常人格特征、性别和基因对肌肉疼痛敏感性的作用。这些信息可能会改进肌肉骨骼疼痛的诊断和治疗策略，通过越来越个性化的患者护理方法来促进医疗保健。