Vanderbilt Multidisciplinary Clinical Research Center

范德比尔特大学多学科临床研究中心（VMCRC）的具体目标是：1）追求一个多学科的临床研究科学计划，将改变风湿性疾病患者的结果。2)通过利用机构培训和研究资源以及支持VMCRC的广泛研究基础，促进和促进风湿性疾病的多学科临床研究，并促进新项目的增长和新研究人员的培训。VMCRC（主任：C。Michael Stein医学博士;副主任：韦恩雷博士）是由三个临床研究项目围绕一个方法核心，服务于所有项目。这三个项目涵盖了一系列临床研究方法（CRC临床研究、药物流行病学、健康结果）和各种风湿性疾病（类风湿性关节炎、狼疮、骨关节炎），这些都是NIAMS使命的核心。项目1（Stein）是一项临床研究/CRC概念验证研究，使用吡格列酮确定类风湿性关节炎患者中高胰岛素血症、疾病活动和炎症之间的关系。项目2（Griffin）研究新的疾病缓解抗风湿药物对心血管疾病、糖尿病、感染和淋巴瘤的长期结局的影响。项目3（库珀）使用独特的当地药物流行病学资源来解决妊娠期间使用抗风湿药物的风险。一个共同的方法核心（Arbogast）为数据的设计、收集和分析提供支持，并为改进所使用的研究方法开发新技术。一个执行委员会和一个外部咨询委员会将协助科学指导、战略规划和最大限度地利用脆弱性、营养和药物审查中心和机构资源。一个行政股将确保负责任、有效地进行研究、无缝沟通、财政效率和周到地优先安排资源。总之，VMCRC汇集了有才华的多学科临床研究人员，他们在进行合作研究，促进新研究和促进学员成长方面有着良好的记录。VMCRC坐落在一个环境，提供了一个非常丰富的研究基础，以及优秀的机构资源和临床研究的承诺，将促进中心的成功。

The Specific Aims of the Vanderbilt University Multidisciplinary Clinical Research Center (VMCRC) are: 1) To pursue a multidisciplinary clinical research scientific program that will alter the outcomes of patients with rheumatic diseases. 2) To promote and foster multidisciplinary clinical research in rheumatic diseases by leveraging institutional training and research resources and the extensive research base that supports the VMCRC and facilitate growth of new projects and the training of new investigators. The VMCRC (Director: C. Michael Stein MD; Associate Director: Wayne Ray PhD) is comprised of three clinical research projects centered around a Methodology Core that serves all projects. The three projects span a range of clinical research approaches (CRC clinical research, pharmacoepidemiology, health outcomes) and diverse rheumatic diseases (rheumatoid arthritis, lupus, osteoarthritis) central to the mission of NIAMS. Project 1 (Stein) is a clinical research/CRC proof-of-concept study using pioglitazone to define the relationships between hyperinsulinemia, disease activity and inflammation in patients with rheumatoid arthritis. Project 2 (Griffin) studies the effect of newer disease modifying anti-rheumatic drugs on the long-term outcomes of cardiovascular disease, diabetes, infection and lymphoma. Project 3 (Cooper) uses a unique local pharmaco-epidemiologic resources to address the risks of anti-rheumatic drugs administered during pregnancy. A common Methodology Core (Arbogast) provides support for the design, collection and analysis of data, and the development of new techniques for improvement of the research methodology used. An Executive Committee and an External Advisory Committee will assist in scientific direction, strategic planning and the leveraging of VMCRC and institutional resources to greatest effect. An Administrative Unit will ensure responsible, efficient conduct of research, seamless communication, fiscal efficiency and thoughtful prioritization of resources. In summary, the VMCRC brings together talented multidisciplinary clinical researchers with a track record in performing collaborative research, fostering new research and facilitating the growth of trainees. The VMCRC is situated in an environment that provides an extraordinarily rich research base as well as outstanding institutional resources and a commitment to clinical research that will facilitate success of the Center.