2012 Synaptic Transmission Gordon Research Conference

描述（由申请人提供）：本提案要求部分支持将于2012年7月29日至8月3日在新罕布什尔州山区的沃特维尔山谷度假村举行的戈登研究会议系列的一部分，即突触传递国际会议。会议的广泛和长期目标是增加我们对突触传递的基本分子和细胞机制的理解。突触是神经系统的基本信号单位。突触传递是大脑功能各个方面的基础，与大多数神经系统疾病以及精神疾病和药物成瘾有关。本次会议的具体目标是召集34位代表突触传递研究关键领域的发言人，共有150名与会者在相对孤立的环境中参加为期五天的会议。该计划将有两个主题讲座和八个会议，广泛解决当前的问题，在纳米尺度的结构和突触的分子机制，通过钙，跨突触信号和突触后修饰的突触传递的调节。一个专门讨论眼睛和耳朵中带状突触的会议将突出突触的结构和功能多样性。另一个会议是专门讨论大脑疾病的突触基础，会议将以突触在电路中的作用的综合会议结束。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。这项应用的意义在于，戈登突触传递研究会议是推动国际突触学家研究的年度系列会议的重要组成部分。本申请的健康相关性在于，讨论将定义需要实验解决广泛的破坏性脑障碍的问题，包括神经变性疾病、精神分裂症、自闭症谱系障碍、药物成瘾、情绪障碍、外周感觉功能丧失和许多其他疾病，这些疾病共同出现为突触病。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Synaptic Transmission as part of the Gordon Research Conference series to be held at the Waterville Valley Resort in the mountains of New Hampshire during the week of July 29-August 3, 2012. The broad and long term goal of the conference is to increase our understanding of the fundamental molecular and cellular mechanisms of synaptic transmission. The synapse serves as the basic signaling unit of the nervous system. Synaptic transmission underlies every aspect of brain function and is relevant to most neurological diseases, as well as mental illness and drug addiction. The specific aims of this meeting will be to convene 34 speakers that represent critical areas of synaptic transmission research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have two keynote lectures and eight sessions that broadly address current issues in the nano-scale structure and molecular machinery of synapses, the regulation of synaptic transmission by calcium, trans-synaptic signaling and postsynaptic modifications. A session devoted to ribbon-type synapses in the eye and ear will highlight structural and functional diversity of synapses. Another session is devoted to the synaptic basis of brain disorders and a meeting will conclude with an integrative session on the role of synapses in circuits. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference on Synaptic Transmission is a critical component of the yearly series of conferences that propel research in the international community of synaptologists. The health relatedness of this application is that the discussions will define the questions that require experimental resolution of a wide range of devastating brain disorders, including neurodegenerative diseases, schizophrenia, autism spectrum disorders, drug addiction, mood disorders, loss of peripheral sensory function and many others, which are collectively emerging as synapto-pathies.