EXPERIMENTAL PATHOLOGY CORE

这个实验病理学核心是P01的一个组成部分，因为它在描述胰腺癌的形态学、分子和代谢表型方面的专业知识，从开始到转移，在不同的状态下，通过靶向遗传操作和人类肿瘤标本的研究来确定。在小鼠模型中评估的遗传改变将在临床PDAC肿瘤中进行翻译和评估，以进行验证。该核心将与项目调查员密切合作，以实现三个具体目标：1)提供组织学服务和咨询专业知识，包括集中审查小鼠和人类胰腺肿瘤的病理评估；Ii)为各种…提供基础设施和技术专长

This Experimental Pathology Core is an integral component of the P01 for its expertise in characterizing the morphologic, molecular and metabolic phenotype of pancreatic cancer, from inception to metastasis, in their diverse states determined by targeted genetic manipulations and study of human tumor specimens. Genetic alterations, as evaluated in mouse models, will be translated and assessed in clinical PDAC tumors for validation purposes. This Core will work in close collaboration with the Project Investigators to achieve three specific aims: 1) to provide histology services and consultative expertise including centralized review in the pathologic evaluation of mouse and human pancreatic neoplasms; ii) to provide infrastructure and technical expertise for a variety of molecular pathologic assays; and iii) to evaluate and implement new ex vivo organotypic culture assays and advanced imaging and analysis technologies that will greatly facilitate these research goals in future. These Aims encompass a wide variety of specialized techniques performed on genetically engineered mouse models, mouse xenograft models, and IRB-approved analysis of human patient tissue specimens. Services will be provided in close Integration with the BioBank Core, Imaging Core and GEM Core. Members of the Experimental Pathology Core have extensive experience in achieving both service-oriented goals as well as pioneering new molecular pathology research tools. The Core will seek to ensure a high quality of interpretive and developmental work to facilitate the goals of the P01.