Targeting Cancer Cells with Functionalized Nanoparticle Libraries

描述（由申请人提供）：我们提出使用两种强大技术的组合：适体选择（通过指数富集的配体系统进化; SELEX）和体外区室化（IVC），以开发产生功能化纳米颗粒文库的新方法，并且可以直接筛选功能。虽然本申请的目标是开发一种用于直接识别定位于人类肿瘤的靶向纳米颗粒的新系统，但我们将开发一种平台技术，该平台技术延伸到癌症和其他疾病的检测和治疗之外，并将导致产生一类新型捕获剂，该捕获剂将用于各种应用和研究领域。

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research.