Targeting Cancer Cells with Functionalized Nanoparticle Libraries

描述(申请人提供)：我们建议结合使用两种强大的技术：适体选择(通过指数富集法对配体的系统进化；SELEX)和体外隔室(IVC)，以开发一种新的方法来生成功能化纳米粒的文库，并可以直接从功能上进行筛选。虽然这项应用的目标是开发一种新的系统，用于直接识别定位于人类肿瘤的靶向纳米颗粒，但我们将开发一种平台技术，其范围超出癌症和其他疾病的检测和治疗，并将导致一种新型捕获剂的产生，该捕获剂将在各种应用和研究领域中使用。 与公共健康相关：我们正在设计一种新的平台技术，该技术将在诊断、治疗和研究应用的各种不同领域发挥巨大作用。我们将利用这项技术开发一类新的针对癌细胞的靶向试剂。

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research. PUBLIC HEALTH RELEVANCE: We are engineering a new platform technology that will be of great utility in a variety of different fields for diagnostic, therapeutic and research applications. We will use this technology to develop a new class of targeting agents that are specific for cancer cells.