Targeting Cancer Cells with Functionalized Nanoparticle Libraries

用功能化纳米粒子库靶向癌细胞

• 批准号: 8080080
• 负责人: MATTHEW LEVY
• 金额: $ 17.5万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-12 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8080080
• 关键词: Affinity; Animal Model; Avidity; Binding; Biological; Cancer Diagnostics; Capsid Proteins; Cells; Detection; Development; Diagnostic; Disease; Engineering; Evolution; Generations; Goals; Human; In Vitro; Individual; Lead; Libraries; Ligands; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of prostate; Methodology; Methods; Microspheres; Modeling; Monitor; Mus; Nucleic Acids; Population; Property; Proteins; Research; Screening for cancer; Serum; Signal Transduction; Surface; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Human Experimentation; Time; Virus; Work; Xenograft procedure; aptamer; base; cancer cell; cancer therapy; nanoparticle; novel; particle; tissue culture; tumor; tumor xenograft

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research. PUBLIC HEALTH RELEVANCE: We are engineering a new platform technology that will be of great utility in a variety of different fields for diagnostic, therapeutic and research applications. We will use this technology to develop a new class of targeting agents that are specific for cancer cells.

描述（由申请人提供）：我们提出使用两种强大技术的组合：适体选择（通过指数富集的配体系统进化; SELEX）和体外区室化（IVC），以开发产生功能化纳米颗粒文库的新方法，并且可以直接筛选功能。虽然本申请的目标是开发一种用于直接识别定位于人类肿瘤的靶向纳米颗粒的新系统，但我们将开发一种平台技术，该平台技术延伸到癌症和其他疾病的检测和治疗之外，并将导致产生一类新型捕获剂，该捕获剂将用于各种应用和研究领域。 公共卫生相关性：我们正在设计一种新的平台技术，该技术将在诊断，治疗和研究应用的各种不同领域中发挥重要作用。我们将利用这项技术开发一类新的靶向药物，专门针对癌细胞。