Targeting Cancer Cells with Functionalized Nanoparticle Libraries

描述（由申请人提供）：我们建议结合两种强大的技术：适体选择（通过指数富集配体的系统进化；SELEX）和体外区隔化（IVC），开发一种新的方法来生成功能化纳米颗粒文库，并可以直接筛选其功能。虽然这项申请的目标是开发一种新的系统，用于直接识别定位于人类肿瘤的靶向纳米颗粒，但我们将开发一种平台技术，它将超越癌症和其他疾病的检测和治疗，并将导致一种新型捕获剂的产生，这种捕获剂将用于各种应用和研究领域。

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research. PUBLIC HEALTH RELEVANCE: We are engineering a new platform technology that will be of great utility in a variety of different fields for diagnostic, therapeutic and research applications. We will use this technology to develop a new class of targeting agents that are specific for cancer cells.