Translational Research in Colon Cancer Prevention & Treatment

结肠癌预防的转化研究

• 批准号: 8530178
• 负责人: Frank A. Sinicrope
• 金额: $ 16.2万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8530178
• 关键词: Adjuvant; Apoptotic; Area; Biological Markers; Cancer Control; Chemoprevention; Colon Carcinoma; Colorectal Cancer; Databases; Development; Epidemiological Factors; Extramural Activities; Funding; Future; Grant; Human; Incidence; Knowledge; Lead; Malignant Neoplasms; Mentors; Molecular Target; Outcome; Population Study; Principal Investigator; Productivity; Recurrence; Research; Research Personnel; Research Project Grants; Signal Pathway; Time; Translational Research; cancer prevention; cancer therapy; colorectal cancer prevention; high risk; improved; novel therapeutics; prevent; prognostic; programs; skills; tissue resource; treatment trial

DESCRIPTION (provided by applicant): The key objectives of this grant are to mentor junior investigators to conduct hypothesis-driven research projects related to colorectal cancer (CRC) prevention. I will utilize my research program and its areas of focus to achieve this objective that will involve mentoring investigators in the following areas: 1) an interventional chemoprevention trial; 2) the study of prognostic and predictive biomarkers, inclusive of epidemiological factors, in relation to cancer outcomes in adjuvant treatment trials; and 3) novel therapeutic strategies for chemoprevention with a focus on apoptotic signaling pathways as molecular targets. These projects represent significant opportunities to conduct timely and clinically important research that builds upon a successful program that utilizes a high risk study population and a unique tissue resource and database from a cancer cooperative group. My overall mentoring objectives are to improve the research knowledge, skills, professional maturity, and academic productivity of junior investigators that will enable them to become independent investigators and future leaders in cancer prevention and control. The K05 grant will also serve another important objective of providing increased protected time for the principal investigator to pursue and expand his ongoing translational research efforts in colorectal cancer that can lead to programmatic expansion and additional extramural funding. Increased protected time will also facilitate my commitment to mentoring and enable me to continue to make important contributions that serve to advance the field of cancer prevention. The end product of these efforts is the potential to reduce cancer incidence and recurrence, thus eliminating suffering related to colorectal cancer.

描述（由申请人提供）：该补助金的主要目标是指导初级研究人员进行与结直肠癌（CRC）预防相关的假设驱动的研究项目。我将利用我的研究计划及其重点领域来实现这一目标，这将涉及指导以下领域的研究人员：1）介入性化学预防试验; 2）预后和预测生物标志物的研究，包括流行病学因素，与辅助治疗试验中的癌症结局有关;和3）用于化学预防的新的治疗策略，其关注于作为分子靶点的凋亡信号传导途径。这些项目代表了进行及时和临床重要研究的重要机会，这些研究建立在利用高风险研究人群和来自癌症合作组的独特组织资源和数据库的成功计划的基础上。我的总体指导目标是提高初级研究人员的研究知识，技能，专业成熟度和学术生产力，使他们能够成为独立的研究人员和未来的领导者在癌症预防和控制。K 05赠款还将服务于另一个重要目标，即为主要研究者提供更多的保护时间，以追求和扩大他在结直肠癌方面正在进行的转化研究工作，这可能导致项目扩展和额外的校外资金。增加受保护的时间也将促进我对指导的承诺，并使我能够继续为推进癌症预防领域做出重要贡献。这些努力的最终结果是有可能降低癌症发病率和复发率，从而消除与结直肠癌有关的痛苦。

项目成果

Serrated polyps of the colon.

结肠锯齿状息肉。

• DOI: 10.3410/m2-89
• 发表时间: 2010
• 期刊: F1000 medicine reports
• 作者: Sugumar,Aravind;Sinicrope,FrankA
• 通讯作者: Sinicrope,FrankA

Clinical implications of microsatellite instability in sporadic colon cancers.

• DOI: 10.1097/cco.0b013e32832c94bd
• 发表时间: 2009-07
• 期刊: Current opinion in oncology
• 影响因子: 3.4
• 作者: Sinicrope FA;Sargent DJ
• 通讯作者: Sargent DJ

Cancer classification using the Immunoscore: a worldwide task force.

• DOI: 10.1186/1479-5876-10-205
• 发表时间: 2012-10-03
• 期刊: Journal of translational medicine
• 影响因子: 7.4
• 作者: Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
• 通讯作者: Fox BA

Combining molecular markers with the TNM staging system to improve prognostication in stage II and III colon cancer: are we ready yet?

将分子标志物与 TNM 分期系统相结合，改善 II 期和 III 期结肠癌的预后：我们准备好了吗？

• DOI: 10.1093/jnci/djs441
• 发表时间: 2012
• 期刊: Journal of the National Cancer Institute
• 作者: Sinicrope,FrankA;Shi,Qian
• 通讯作者: Shi,Qian

Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer.

• DOI: 10.2217/fon.11.5
• 发表时间: 2011-03
• 期刊: Future oncology (London, England)
• 作者: Sinicrope FA;Yang ZJ
• 通讯作者: Yang ZJ