Translational Research in Colon Cancer Prevention & Treatment

描述(由申请者提供)：这项资助的主要目标是指导初级研究人员进行与结直肠癌预防相关的假设驱动的研究项目。我将利用我的研究计划及其重点领域来实现这一目标，这将涉及指导以下领域的研究人员：1)干预性化学预防试验；2)与辅助治疗试验中的癌症结果有关的预后和预测性生物标记物的研究，包括流行病学因素；以及3)化学预防的新治疗策略，重点是作为分子靶标的细胞凋亡信号通路。这些项目代表着进行及时和临床重要研究的重要机会，这些研究建立在一个成功的计划的基础上，该计划利用了来自癌症合作小组的高风险研究人群和独特的组织资源和数据库。我的总体指导目标是提高初级研究人员的研究知识、技能、专业成熟度和学术生产率，使他们能够成为独立的调查人员和癌症预防和控制领域的未来领导者。K05拨款还将服务于另一个重要目标，即为主要研究人员提供更多的受保护时间，以继续和扩大他正在进行的结直肠癌转化研究工作，这可能导致计划的扩大和额外的外部资金。更长的保护时间也将促进我对指导的承诺，并使我能够继续为推进癌症预防领域做出重要贡献。这些努力的最终结果是有可能减少癌症的发病率和复发，从而消除与结直肠癌有关的痛苦。

DESCRIPTION (provided by applicant): The key objectives of this grant are to mentor junior investigators to conduct hypothesis-driven research projects related to colorectal cancer (CRC) prevention. I will utilize my research program and its areas of focus to achieve this objective that will involve mentoring investigators in the following areas: 1) an interventional chemoprevention trial; 2) the study of prognostic and predictive biomarkers, inclusive of epidemiological factors, in relation to cancer outcomes in adjuvant treatment trials; and 3) novel therapeutic strategies for chemoprevention with a focus on apoptotic signaling pathways as molecular targets. These projects represent significant opportunities to conduct timely and clinically important research that builds upon a successful program that utilizes a high risk study population and a unique tissue resource and database from a cancer cooperative group. My overall mentoring objectives are to improve the research knowledge, skills, professional maturity, and academic productivity of junior investigators that will enable them to become independent investigators and future leaders in cancer prevention and control. The K05 grant will also serve another important objective of providing increased protected time for the principal investigator to pursue and expand his ongoing translational research efforts in colorectal cancer that can lead to programmatic expansion and additional extramural funding. Increased protected time will also facilitate my commitment to mentoring and enable me to continue to make important contributions that serve to advance the field of cancer prevention. The end product of these efforts is the potential to reduce cancer incidence and recurrence, thus eliminating suffering related to colorectal cancer.