Chemistry and Mechanisms for Environmental Stress

描述（由申请人提供）：本申请请求支持美国化学学会（ACS）化学毒理学分部在2013年9月8日（星期日）至2013年9月11日（星期三）在印第安纳州印第安纳波利斯举行的第246届全国会议和博览会上的规划。本次ACS会议的一个独特之处是全国会议的广泛主题，“化学运动”，它使ACS所有部门的规划中突出的事件保持一致。ACS化学毒理学部的使命是促进对疾病过程和环境因子、生物材料、药物和内源性化学品毒性的化学机制的理解。该司整合了化学、化学生物学、结构生物学、毒理学、环境健康科学和疾病机制方面的工作。三个相互关联的专题讨论会计划围绕中心主题“化学和环境压力的机制”，包括邀请不同的领先的既定和新兴的科学家小组的谈话。要求得到支助的三个专题讨论会与国家经济和社会卫生研究所的使命特别相关。第一份题为“毒理学中的代谢组学”，重点介绍了全球特征分析技术和系统分析数据整合工具的实施情况。第二个主题是“金属毒性的化学和生物学”，重点是金属-生物分子相互作用及其系统效应的新机制研究。第三次专题讨论会题为“替代燃料的毒理学”，重点是吸入毒性机制和致癌作用。提供论文会议和青年研究人员专题讨论会为接受培训的青年科学家提供机会，介绍他们的主要贡献，并从资深专家那里获得重要反馈。其他亮点是Christopher Austin博士（国家推进转化科学中心主任）的主题演讲和两个备受瞩目的奖项研讨会（创始人奖和毒理学化学研究青年研究者奖）。这些会议（由非联邦基金支持）将进一步加强一个强大的整体计划，并为不同的参与者提供当前在环境暴露和疾病的化学和生物学工作的杰出代表。

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 246th National Meeting and Exposition in Indianapolis, IN from Sunday, September 8, 2013 to Wednesday, September 11, 2013. A unique feature of this ACS meeting is the broad theme of the national meeting, "Chemistry in Motion", which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Three interrelated symposia are planned around the central theme "Chemistry and Mechanisms of Environmental Stress" and include invited talks by a diverse group of leading established and emerging scientists. The three symposia for which support is requested have especially strong relevance to the mission of the NIEHS. The first is entitled "Metabolomics in Toxicology" and highlights the implementation of global profiling technologies and data integration tools for systems analysis. The second is entitled "Chemistry and Biology of Metal Toxicity" and focuses on new mechanistic studies of metal-biomolecule interactions and their systemic effects. The third symposium session is entitled "Toxicology of Alternative Fuels" and focuses on inhalation toxicity mechanisms and carcinogenesis. A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote lecture by Dr. Christopher Austin (Director of the National Center for Advancing Translational Sciences) and two high profile award symposia (the Founders Award and the Chemical Research in Toxicology Young Investigator Award). These sessions (supported by non-federal funds) will further enhance a strong overall program and provide diverse participants an outstanding representation of current work in the chemistry and biology of environmental exposures and disease.