Chemistry and Mechanisms for Environmental Stress

描述（由申请人提供）：本申请申请为2013年9月8日（周日）至2013年9月11日（周三）在印第安纳州印第安纳波利斯举行的第246届美国化学会（ACS）化学毒理学分会的规划提供支持。这次ACS会议的一个独特之处在于，全国会议的主题是“运动中的化学”，它将ACS所有部门的重点活动结合在一起。美国化学学会化学毒理学分部的使命是促进对疾病过程的化学机制的理解，以及环境因子、生物材料、药物和内源性化学品的毒性。该司综合了化学、化学生物学、结构生物学、毒理学、环境卫生科学和疾病机制方面的工作。围绕“环境压力的化学和机制”的中心主题，计划举行三个相互关联的专题讨论会，并邀请来自不同群体的知名和新兴科学家进行演讲。要求提供支持的三个专题讨论会与NIEHS的使命特别密切相关。第一篇题为“毒理学中的代谢组学”，重点介绍了用于系统分析的全球分析技术和数据集成工具的实施。第二个主题是“金属毒性的化学和生物学”，重点是金属-生物分子相互作用及其系统效应的新机制研究。第三次专题讨论会题为“替代燃料毒理学”，重点讨论吸入毒性机制和致癌作用。提供的论文会议和青年研究人员研讨会为正在接受培训的青年科学家提供了展示他们的主要贡献和接受资深专家的关键反馈的机会。其他亮点是克里斯托弗·奥斯汀博士（国家促进转化科学中心主任）的主题演讲和两个备受瞩目的奖项座谈会（创始人奖和毒理学化学研究青年研究员奖）。这些会议（由非联邦基金支持）将进一步加强一个强有力的整体方案，并为不同的参与者提供环境暴露和疾病的化学和生物学方面当前工作的杰出代表。

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 246th National Meeting and Exposition in Indianapolis, IN from Sunday, September 8, 2013 to Wednesday, September 11, 2013. A unique feature of this ACS meeting is the broad theme of the national meeting, "Chemistry in Motion", which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Three interrelated symposia are planned around the central theme "Chemistry and Mechanisms of Environmental Stress" and include invited talks by a diverse group of leading established and emerging scientists. The three symposia for which support is requested have especially strong relevance to the mission of the NIEHS. The first is entitled "Metabolomics in Toxicology" and highlights the implementation of global profiling technologies and data integration tools for systems analysis. The second is entitled "Chemistry and Biology of Metal Toxicity" and focuses on new mechanistic studies of metal-biomolecule interactions and their systemic effects. The third symposium session is entitled "Toxicology of Alternative Fuels" and focuses on inhalation toxicity mechanisms and carcinogenesis. A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote lecture by Dr. Christopher Austin (Director of the National Center for Advancing Translational Sciences) and two high profile award symposia (the Founders Award and the Chemical Research in Toxicology Young Investigator Award). These sessions (supported by non-federal funds) will further enhance a strong overall program and provide diverse participants an outstanding representation of current work in the chemistry and biology of environmental exposures and disease.