Chemistry of Preventing and Combating Disease

防病化学

• 批准号: 8006281
• 负责人: Daniel C Liebler
• 金额: $ 0.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006281
• 关键词: Address; American; Area; Award; Biological Markers; Biology; Boston; Characteristics; Chemicals; Chemistry; Disease; Environmental Exposure; Environmental Health; Event; Exposure to; Inflammation; Inflammatory; Intervention; Link; Mission; Molecular; National Institute of Environmental Health Sciences; Nitrogen; Oxygen; Paper; Pathway interactions; Post-Translational Protein Processing; Postdoctoral Fellow; Prevention; Process; Proteins; Request for Applications; Research; Research Personnel; Role; Scientist; Signal Pathway; Signal Transduction; Societies; Stress; Students; Toxic effect; Toxicology; Translating; Work; adduct; biological adaptation to stress; combat; environmental agent; inflammatory marker; meetings; prevent; programs; public health relevance; structural biology; symposium

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 240th National Meeting and Exposition in Boston, MA from Sunday, 22-Aug-2010 to Wednesday, 25-Aug-2010. A unique feature of this ACS meeting is the broad theme of the entire meeting--"Chemistry of Preventing and Combating Disease," which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, drugs and endogenous chemicals. The division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. The global theme "Chemistry of Preventing and Combating Disease" aligns closely with the core focus areas of the Division of Chemical Toxicology and thus provides a thematic backdrop that reinforces programming in the Division and provides related content particularly for students and postdoctoral fellows. Four interrelated sessions are planned around the central theme "Chemistry of Preventing and Combating Disease" and include invited talks by a diverse group of leading established and up-and-coming scientists presenting their recent research results. The two sessions for which support is requested have especially strong relevance to the mission of the NIEHS. The first (Symposium #1) is entitled "Protein adducts and stress response pathways" and addresses molecular mechanisms by which electrophiles and reactive oxygen and nitrogen species trigger stress and adaptive signaling pathways by selective modification of protein targets. The second (Symposium #4) is entitled "Inflammation markers and interventions" and addresses the chemistry of reactive species involved in inflammation, the formation of characteristic molecular species that may serve as biomarkers for inflammatory processes and the role of inflammation as an integrating mechanism for disease processes associated with environmental exposures. Proffered paper sessions and a Young Investigators Symposium offer opportunities for young investigators to present their primary contributions. Other highlights are a keynote awards symposium and scientific perspectives address. PUBLIC HEALTH RELEVANCE: Effective prevention and treatment of environmentally-related diseases requires an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will examine the chemical mechanisms by which molecular damage translates to disease. Specifically, the sponsored symposia will examine new work on how inflammation and molecular damage processes create signals that trigger environmentally-induced disease processes.

说明（由申请人提供）：本申请请求支持美国化学会 (ACS) 化学毒理学部于 2010 年 8 月 22 日星期日至 2010 年 8 月 25 日星期三在马萨诸塞州波士顿举行的第 240 届全国会议和博览会上的规划。本次 ACS 会议的一个独特之处是整个会议的广泛主题——“预防和对抗疾病的化学”，它将所有 ACS 部门的重点活动结合起来。 ACS 化学毒理学部的使命是促进对导致疾病过程以及环境因素、药物和内源性化学物质毒性的化学机制的理解。该部门整合了化学、化学生物学、结构生物学、毒理学、环境健康科学和疾病机制方面的工作。全球主题“预防和对抗疾病的化学”与化学毒理学部的核心重点领域密切相关，从而提供了一个加强该部规划的主题背景，并特别为学生和博士后研究员提供相关内容。围绕“预防和对抗疾病的化学”这一中心主题，计划举办四场相互关联的会议，其中包括由不同领域的知名和崭露头角的科学家邀请的演讲，介绍他们的最新研究成果。请求支持的两场会议与 NIEHS 的使命尤其密切相关。第一场（研讨会#1）的标题是“蛋白质加合物和应激反应途径”，探讨了亲电子试剂、活性氧和氮物质通过选择性修饰蛋白质靶标触发应激和适应性信号传导途径的分子机制。第二场（研讨会＃4）的标题是“炎症标志物和干预措施”，讨论了炎症中涉及的反应性物质的化学、可作为炎症过程生物标志物的特征性分子种类的形成以及炎症作为与环境暴露相关的疾病过程的整合机制的作用。提供的论文会议和青年研究人员研讨会为年轻研究人员提供了展示其主要贡献的机会。其他亮点包括主题颁奖研讨会和科学观点演讲。 公共卫生相关性：有效预防和治疗与环境相关的疾病需要了解将环境暴露与疾病机制联系起来的潜在机制。 美国化学会化学毒理学部的这次会议将研究分子损伤转化为疾病的化学机制。 具体来说，赞助的研讨会将研究关于炎症和分子损伤过程如何产生触发环境诱发的疾病过程的信号的新工作。