CHRiSS: Cardiac Health Risk Stratification System

CHRiSS：心脏健康风险分层系统

• 批准号: 8592756
• 负责人: JAMES F. ANTAKI
• 金额: $ 15万
• 依托单位: BLENDERHOUSE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8592756
• 关键词: Address; Adoption; Adverse event; Algorithms; American; Benefits and Risks; Businesses; Cardiac; Caring; Clinical; Communication; Computer software; Computerized Medical Record; Cost Effectiveness Analysis; Cost Savings; Data; Development; Diagnosis; Education; Evaluation; Event; Feasibility Studies; Foundations; Guidelines; Health; Health Care Costs; Health system; Heart failure; Heart-Assist Devices; Hospitals; Incidence; Institution; Intensive Care; Interview; Knowledge; Lead; Length of Stay; Life; Life Style; Machine Learning; Marketing; Medical; Medicare; Methods; Metric; Mining; Modeling; Needs Assessment; Outcome; Outpatients; Patients; Phase; Postoperative Period; Public Health; Quality of life; Risk; Savings; Software Tools; Staging; Stratification; Structure; System; Technology; Testing; Update; Work; computer human interaction; cost; data mining; design; graphical user interface; implantation; improved; mortality; outcome forecast; patient population; preference; prognostic; programs; prototype; public health relevance; satisfaction; success; tool; trend; usability; ventricular assist device

DESCRIPTION (provided by applicant): SUMMARY This project aims to produce and beta-test a clinical decision support application for end- stage heart failure, titled CHRiSS: Cardiac Health Risk Stratification System. It will be designed for patients with progressive heart failure who may eventually become candidates for ventricular assist device (VAD) therapy. The software will be build upon existing machine learning and data mining technology, developed by the PI and colleagues, designed to predict 90-day mortality following VAD implantation. This Phase- 1 effort will entail development of graphic user interfaces for both patients and clinicians to incorporate personalized prognostic information into a functional decision-support utility. The inference algorithm will also be expanded to encompass adverse events, and risk of readmission. In this Phase-1 feasibility project, CHRiSS will be programmed and beta-tested at West Penn Allegheny Health System (WPAHS). This will entail semi- structured interviews to collect relevant expert knowledge, and mining the electronic medical records (EMR) to calibrate the prognostic algorithm to the institution-specific data. Successful completion of this Phase I project will lead to a multi-center trial in which the software is fully validated. Ultimate succes of this project will result in a software application that will optimize the benefit of VAD therapy to public health, while reducing cost by reducing the unacceptably high rate of adverse events and unnecessary readmissions.

描述（由申请人提供）：总结本项目旨在生产和测试终末期心力衰竭的临床决策支持应用程序，标题为CHRiSS：心脏健康风险分层系统。它将被设计用于患有进行性心力衰竭的患者，这些患者最终可能成为心室辅助装置（VAD）治疗的候选人。该软件将基于PI及其同事开发的现有机器学习和数据挖掘技术，旨在预测VAD植入后90天的死亡率。第一阶段的工作将需要为患者和临床医生开发图形用户界面 将个性化的预后信息纳入功能性决策支持工具。推理算法也将扩展到包括不良事件和再入院风险。在这个第一阶段的可行性项目中，CHRiSS将在西宾夕法尼亚州阿勒格尼卫生系统（WPAHS）进行编程和测试。这将需要半结构化访谈来收集相关的专家知识，并挖掘电子病历（EMR）来校准针对机构特定数据的预后算法。该I期项目的成功完成将导致多中心试验，其中软件得到充分验证。该项目的最终成功将产生一个软件应用程序，该软件应用程序将优化VAD治疗的益处， 公共卫生，同时通过降低不可接受的高不良事件率和不必要的再入院来降低成本。