CHRiSS: Cardiac Health Risk Stratification System

CHRiSS：心脏健康风险分层系统

• 批准号: 8592756
• 负责人: JAMES F. ANTAKI
• 金额: $ 15万
• 依托单位: BLENDERHOUSE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8592756
• 关键词: Address; Adoption; Adverse event; Algorithms; American; Benefits and Risks; Businesses; Cardiac; Caring; Clinical; Communication; Computer software; Computerized Medical Record; Cost Effectiveness Analysis; Cost Savings; Data; Development; Diagnosis; Education; Evaluation; Event; Feasibility Studies; Foundations; Guidelines; Health; Health Care Costs; Health system; Heart failure; Heart-Assist Devices; Hospitals; Incidence; Institution; Intensive Care; Interview; Knowledge; Lead; Length of Stay; Life; Life Style; Machine Learning; Marketing; Medical; Medicare; Methods; Metric; Mining; Modeling; Needs Assessment; Outcome; Outpatients; Patients; Phase; Postoperative Period; Public Health; Quality of life; Risk; Savings; Software Tools; Staging; Stratification; Structure; System; Technology; Testing; Update; Work; computer human interaction; cost; data mining; design; graphical user interface; implantation; improved; mortality; outcome forecast; patient population; preference; prognostic; programs; prototype; public health relevance; satisfaction; success; tool; trend; usability; ventricular assist device

DESCRIPTION (provided by applicant): SUMMARY This project aims to produce and beta-test a clinical decision support application for end- stage heart failure, titled CHRiSS: Cardiac Health Risk Stratification System. It will be designed for patients with progressive heart failure who may eventually become candidates for ventricular assist device (VAD) therapy. The software will be build upon existing machine learning and data mining technology, developed by the PI and colleagues, designed to predict 90-day mortality following VAD implantation. This Phase- 1 effort will entail development of graphic user interfaces for both patients and clinicians to incorporate personalized prognostic information into a functional decision-support utility. The inference algorithm will also be expanded to encompass adverse events, and risk of readmission. In this Phase-1 feasibility project, CHRiSS will be programmed and beta-tested at West Penn Allegheny Health System (WPAHS). This will entail semi- structured interviews to collect relevant expert knowledge, and mining the electronic medical records (EMR) to calibrate the prognostic algorithm to the institution-specific data. Successful completion of this Phase I project will lead to a multi-center trial in which the software is fully validated. Ultimate succes of this project will result in a software application that will optimize the benefit of VAD therapy to public health, while reducing cost by reducing the unacceptably high rate of adverse events and unnecessary readmissions.

本项目旨在制作并测试终末期心力衰竭的临床决策支持应用程序，名为CHRiSS：心脏健康风险分层系统。它将被设计用于可能最终成为心室辅助装置（VAD）治疗候选人的进行性心力衰竭患者。该软件将建立在由PI及其同事开发的现有机器学习和数据挖掘技术的基础上，旨在预测VAD植入后90天的死亡率。这个第一阶段的努力将需要为患者和临床医生开发图形用户界面