CORA_TM_A Personalized Cardiac Counselor for Optimal Therapy
CORA_TM_最佳治疗的个性化心脏咨询师
基本信息
- 批准号:9675403
- 负责人:
- 金额:$ 81.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-03 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdmission activityAdverse effectsAdverse eventAffectAlgorithmsAmericanAmerican Heart AssociationAnxietyAttitudeBeliefBenefits and RisksBiomedical EngineeringCardiacCardiac Surgery proceduresCardiologyCaregiver BurdenCaregiver supportCaregiversCaringCessation of lifeClinicalClinical DataClinical Decision Support SystemsCollaborationsColoradoCommunicationComprehensionComputer softwareComputersCongestive Heart FailureConsensusConsultationsDataDatabasesDecision MakingDecision ModelingDependenceDestinationsDevicesDiseaseDyspneaEnvironmentFamilyFamily CaregiverFoundationsFrequenciesFundingFutureGuidelinesHealthHealth PersonnelHeart failureHeart-Assist DevicesHeart-Lung TransplantationHospitalsImageryImplantIncidenceInfectionInstitutionIntentionInteragency Registry for Mechanically Assisted Circulatory SupportInternationalInterventionInterviewKnowledgeLeadLength of StayLifeLife ExpectancyMachine LearningMechanicsMedicalMedical EthicsMedicareMental DepressionMeta-AnalysisMorbidity - disease rateMulticenter StudiesMulticenter TrialsMuscular AtrophyOutcomePalliative CarePatient-Focused OutcomesPatientsPhysiciansProbabilityProcessProfessional counselorProviderPublishingQuality of lifeRiskRisk AssessmentSavingsSocietiesStentsStressStrokeSupervisionSystemTechnologyTimeTouch sensationTrainingTreatment EffectivenessUnited States National Institutes of HealthUniversitiesWomanWorkbaseclinical research sitecomputer programcomputer sciencecost effectivenessdata miningdata visualizationdesigndiscountexperienceimplantable deviceimprovedindividual patientinteractive toolleft ventricular assist deviceliteracymedical specialtiesmeetingsmortalitymultidisciplinarynon-complianceoptimal treatmentsoutcome forecastpatient responsepredictive modelingpreferenceprognosticprospectiveprototypepublic health relevancereadmission ratessatisfactionshared decision makingtechnology validationtooltreatment planningtreatment strategyusabilityuser-friendlyventricular assist devicewillingness
项目摘要
DESCRIPTION (provided by applicant): This project aims to introduce a clinical decision support system, CORA (Cardiac Outcomes Risk Assessment) for advanced heart failure (HF) a devastating disease affecting over 5 million Americans, and a leading cause of Medicare hospital admissions. The project specifically aims to moderate the deployment ventricular assist devices (VADs) which have been recently approved as destination (DT) such that patients most likely to benefit will be prioritized, while those better served with palliative care will be spare from unnecessary risks of debilitating side effects. The proposed system will leverage proven prognostic models based on advanced data mining and machine learning algorithms, and be packaged as a user-friendly computer application that would be used at key decision points in the course of treatment. It would provide both physician and patient with prognostic assessment based on the fusion of: patient-specific data, expert knowledge, and retrospective meta-analysis. This four-year project will develop a multi-platform software application that integrates
modules for: forecasting, decision support, communication, decision making and visualization of data. This will be achieved through completion of four specific aims: (SA1) Expand existing inference (prognostic) algorithms and develop expert decision models to compute personalized estimate of life expectancy and risk of adverse events; (SA2) Create a computer application to assist patients to navigate their treatment options as they reflect their personal preferences and beliefs; (SA3) Incorporate these prognostic and decision models into user-friendly user interfaces for physicians, patients and their family caregivers; and (SA4) Conduct a multi- center study with respect to both qualitative and quantitative metrics of efficacy related to mortality, morbidity and quality of life. Training data capitalizing upon the NIH-funded Interagency Registry for Mechanical Circulatory Support (INTERMACS) as well as recently published guidance documents by the American Heart Association (AHA) and International Society of Heart & Lung Transplantation (ISHLT.) This project will involve a multi-disciplinary group of specialties including: bioengineering, advanced heart failure cardiology, cardiac surgery, computer science (machine learning/data mining), medical ethics, and palliative care. Carnegie Mellon University, one of the Nation's leading institutions for Computer Science will coordinate this project to assure a productive collaboration with four clinical sites: Allegheny Health Network (Pittsburgh), U. Colorado Denver, Duke University, and Harvard/Brigham & Women's hospital. By achieve consensus amongst stakeholders, we hope to assure the acceptance of CORA into practice and ultimately improve the efficiency, efficacy, and cost- effectiveness of the treatment of end-stage heart failure.
描述(由申请人提供):该项目旨在介绍一种临床决策支持系统,CORA(心脏结局风险评估),用于晚期心力衰竭(HF),这是一种影响超过500万美国人的毁灭性疾病,也是医疗保险住院的主要原因。该项目的具体目标是适度部署心室辅助装置(VAD),这些装置最近已被批准为目的地(DT),以便优先考虑最有可能受益的患者,而那些更好地接受姑息治疗的患者将免于不必要的衰弱副作用风险。拟议的系统将利用基于先进数据挖掘和机器学习算法的经验证的预后模型,并将其打包为用户友好的计算机应用程序,用于治疗过程中的关键决策点。它将为医生和患者提供基于融合的预后评估:患者特异性数据,专家知识和回顾性荟萃分析。这个为期四年的项目将开发一个多平台的软件应用程序,
模块:预测,决策支持,通信,决策和数据可视化。这将通过完成四个具体目标来实现:(SA 1)扩展现有推理(SA 2)创建计算机应用程序以帮助患者导航他们的治疗选项,因为它们反映了他们的个人偏好和信念;(SA 3)将这些预后和决策模型纳入医生、患者及其家庭护理人员的用户友好用户界面中;以及(SA 4)针对与死亡率、发病率和生活质量相关的疗效的定性和定量度量进行多中心研究。培训数据利用了NIH资助的机械循环支持机构间登记处(INTERMACS)以及美国心脏协会(AHA)和国际心肺移植学会(ISHLT)最近发布的指导文件。该项目将涉及多学科的专业组,包括:生物工程,先进的心力衰竭心脏病学,心脏手术,计算机科学(机器学习/数据挖掘),医学伦理学和姑息治疗。卡内基梅隆大学,美国领先的计算机科学机构之一,将协调这一项目,以确保与四个临床网站的生产合作:阿勒格尼健康网络(匹兹堡),美国。科罗拉多丹佛,杜克大学,和哈佛/布里格姆妇女医院。通过在利益相关者之间达成共识,我们希望确保CORA被接受并付诸实践,并最终提高终末期心力衰竭治疗的效率、疗效和成本效益。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Limitations of receiver operating characteristic curve on imbalanced data: Assist device mortality risk scores.
- DOI:10.1016/j.jtcvs.2021.07.041
- 发表时间:2023-04
- 期刊:
- 影响因子:0
- 作者:Movahedi F;Padman R;Antaki JF
- 通讯作者:Antaki JF
A Bayesian Model to Predict Survival After Left Ventricular Assist Device Implantation.
- DOI:10.1016/j.jchf.2018.03.016
- 发表时间:2018-09
- 期刊:
- 影响因子:0
- 作者:Kanwar MK;Lohmueller LC;Kormos RL;Teuteberg JJ;Rogers JG;Lindenfeld J;Bailey SH;McIlvennan CK;Benza R;Murali S;Antaki J
- 通讯作者:Antaki J
Timelines of adverse event journeys of LVAD patients.
LVAD 患者不良事件经历的时间表。
- DOI:10.1111/aor.14596
- 发表时间:2023
- 期刊:
- 影响因子:2.4
- 作者:Movahedi,Faezeh;Kanwar,ManreetK;Antaki,JamesF
- 通讯作者:Antaki,JamesF
Risk Assessment in Patients with a Left Ventricular Assist Device Across INTERMACS Profiles Using Bayesian Analysis.
使用贝叶斯分析对 INTERMACS 档案中左心室辅助装置患者进行风险评估。
- DOI:10.1097/mat.0000000000000910
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Kanwar,ManreetK;Lohmueller,LisaC;Teuteberg,Jeffrey;Kormos,RobertL;Rogers,JosephG;Benza,RaymondL;Lindenfeld,Joann;McIlvennan,Colleen;Bailey,StephenH;Murali,Srinivas;Antaki,JamesF
- 通讯作者:Antaki,JamesF
Retrospective Evaluation of Bayesian Risk Models of LVAD Mortality at a Single Implant Center.
- DOI:10.3389/fmed.2018.00277
- 发表时间:2018
- 期刊:
- 影响因子:3.9
- 作者:Lohmueller LC;Kanwar MK;Bailey S;Murali S;Antaki JF
- 通讯作者:Antaki JF
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JAMES F. ANTAKI其他文献
JAMES F. ANTAKI的其他文献
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{{ truncateString('JAMES F. ANTAKI', 18)}}的其他基金
Multiscale Model of Thrombosis in Artificial Circulation
人工循环血栓形成的多尺度模型
- 批准号:
9925233 - 财政年份:2018
- 资助金额:
$ 81.46万 - 项目类别:
CORA_TM_A Personalized Cardiac Counselor for Optimal Therapy
CORA_TM_最佳治疗的个性化心脏咨询师
- 批准号:
9199427 - 财政年份:2015
- 资助金额:
$ 81.46万 - 项目类别:
CORA_TM_A Personalized Cardiac Counselor for Optimal Therapy
CORA_TM_最佳治疗的个性化心脏咨询师
- 批准号:
8818809 - 财政年份:2015
- 资助金额:
$ 81.46万 - 项目类别:
CORA_TM_A Personalized Cardiac Counselor for Optimal Therapy
CORA_TM_最佳治疗的个性化心脏咨询师
- 批准号:
8995683 - 财政年份:2015
- 资助金额:
$ 81.46万 - 项目类别:
CHRiSS: Cardiac Health Risk Stratification System
CHRiSS:心脏健康风险分层系统
- 批准号:
8592756 - 财政年份:2013
- 资助金额:
$ 81.46万 - 项目类别:
Blood Filtration System for the Treatment of Severe Malaria Patients
用于治疗重症疟疾患者的血液过滤系统
- 批准号:
8532028 - 财政年份:2012
- 资助金额:
$ 81.46万 - 项目类别:
Blood Filtration System for the Treatment of Severe Malaria Patients
用于治疗重症疟疾患者的血液过滤系统
- 批准号:
8393331 - 财政年份:2012
- 资助金额:
$ 81.46万 - 项目类别:
MULTI-SCALE MODEL OF THORMBOSIS IN ARTIFICIAL CIRCULATION
人工循环中血栓形成的多尺度模型
- 批准号:
7585083 - 财政年份:2009
- 资助金额:
$ 81.46万 - 项目类别: